公开(公告)号：EP3193918A4

公开(公告)日：2018-06-20

申请号：EP15841265

申请日：2015-09-18

申请人： UNIV MARYLAND

发明人： SIMON RAPHAEL ,  CROSS ALAN ,  TENNANT SHARON

IPC分类号： A61K39/00 ,  A61K39/104 ,  A61K39/108 ,  A61K39/116 ,  C07K14/21 ,  C07K14/26 ,  C12N1/20 ,  C12N1/21 ,  C12R1/22 ,  C12R1/42

CPC分类号： C07K14/26 ,  A61K39/0266 ,  A61K39/104 ,  A61K39/116 ,  A61K47/4833 ,  A61K2039/70 ,  C07K14/21 ,  C07K2319/00

摘要： The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O5 polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and 012. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.

公开(公告)号：EP2387417A4

公开(公告)日：2012-06-20

申请号：EP10732190

申请日：2010-01-16

申请人： UNIV MARYLAND

发明人： LEVINE MYRON M ,  SIMON RAPHAEL ,  GALEN JAMES ,  TENNANT SHARON

IPC分类号： A61K39/112 ,  A61K39/02 ,  A61P31/12 ,  C12N1/21

CPC分类号： A61K39/0275 ,  A61K2039/522 ,  A61K2039/6068 ,  A61K2039/627

摘要： The present invention is drawn to attenuated Salmonella serovar strains S. Typhimurium and S. Enteritidis, conjugate vaccines derived from these attenuated strains of S. Typhimurium and S. Enteritidis, comprising an O polysaccharide covalently linked to a flagellin protein, and methods for inducing an immune response in a subject comprising administering the attenuated strains and/or the conjugate vaccines of the invention.