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公开(公告)号：EP2387417A4
公开(公告)日：2012-06-20
申请号：EP10732190
申请日：2010-01-16
申请人： UNIV MARYLAND
发明人： LEVINE MYRON M , SIMON RAPHAEL , GALEN JAMES , TENNANT SHARON
IPC分类号： A61K39/112 , A61K39/02 , A61P31/12 , C12N1/21
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/6068 , A61K2039/627
摘要： The present invention is drawn to attenuated Salmonella serovar strains S. Typhimurium and S. Enteritidis, conjugate vaccines derived from these attenuated strains of S. Typhimurium and S. Enteritidis, comprising an O polysaccharide covalently linked to a flagellin protein, and methods for inducing an immune response in a subject comprising administering the attenuated strains and/or the conjugate vaccines of the invention.
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公开(公告)号：EP0734451A4
公开(公告)日：1997-11-26
申请号：EP95903130
申请日：1994-12-01
申请人： UNIV MARYLAND
IPC分类号： C12N15/09 , A61K38/00 , A61K39/112 , A61K39/395 , C07H21/04 , C07K14/25 , C07K16/12 , C12N1/21 , C12P21/02 , C12P21/04 , C12R1/01 , A01N63/00 , C07H17/00 , C07H19/00 , C07H21/00 , C07K1/00 , C07K2/00 , C07K4/00 , C07K14/00 , C07K16/00
CPC分类号： C07K16/1203 , A61K38/00 , C07K14/25 , C12R1/01 , Y10S530/825
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3.发明公开ATTENUATED SALMONELLA ENTERICA SEROVAR PARATYPHI A AND USES THEREOF 有权GEDÄMPFTEENTERISCHE SALMONELLEN-PARATYPHI A UND VERWENDUNGEN DAVON
公开(公告)号：EP2403525A4
公开(公告)日：2013-04-03
申请号：EP10749113
申请日：2010-02-24
申请人： UNIV MARYLAND
IPC分类号： A61K39/112 , C12N1/21 , C12N15/31 , C12R1/42
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/6068 , C12N1/36
摘要： The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression system, an S. Paratyphi conjugate vaccine, and methods of using these strains and conjugate vaccine.
摘要翻译： 本发明涉及一种活的减毒副伤寒沙雷氏菌A菌株，一种活的减毒的副伤寒沙雷氏菌菌株，其包含稳定的质粒表达系统，副伤寒沙门氏菌疫苗以及使用这些菌株和结合疫苗的方法。
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4.发明公开
公开(公告)号：EP1941024A4
公开(公告)日：2012-03-21
申请号：EP06844230
申请日：2006-10-30
申请人： UNIV MARYLAND
CPC分类号： C12N1/20 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K2039/522 , A61K2039/523 , C12N1/36 , C12N9/0006 , C12N9/14 , C12N9/52 , C12N9/93 , C12N15/74
摘要： The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression system, and methods of using these strains.
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5.发明公开ATTENUATED MUTANTS OF $i(SALMONELLA) WHICH CONSTITUTIVELY EXPRESS THE Vi ANTIGEN 有权减毒沙门氏菌突变体DAS VI-抗原表达CONSTANT
公开(公告)号：EP1076566A4
公开(公告)日：2005-01-05
申请号：EP99919755
申请日：1999-04-30
申请人： UNIV MARYLAND
IPC分类号： C12N15/09 , A61K39/00 , A61K39/02 , A61K39/08 , A61K39/112 , A61K48/00 , A61P31/04 , A61P37/04 , C07K14/255 , C12N1/20 , C12N1/21 , C12N15/74 , C12R1/42 , A01N63/00 , A01N65/00 , A61K39/38 , C12N1/00 , C12N1/36 , C12N13/00 , C12P21/04
CPC分类号： C12N15/74 , A61K39/00 , A61K39/0275 , A61K39/08 , A61K2039/522 , A61K2039/523 , C07K14/255 , C12N1/20 , Y10S424/831 , Y10S435/879
摘要： Attenuated Salmonella mutants which constitutively express the Vi antigen are disclosed, as well as vaccines against typhoid fever containing the same, live vector vaccines containing the same, and DNA-mediated vaccines containing the same.
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6.发明公开$i(VIBRIO CHOLERAE) 01 (CVD111) AND NON-01 (CVD112 AND CVD112RM) SEROGROUP VACCINE STRAINS AND METHODS OF MAKING SAME 失效-i血清群01（CVD111）和非01（CVD112 AND CVD112RM）（霍乱弧菌）的疫苗株及其制备方法
公开(公告)号：EP0722339A4
公开(公告)日：2001-05-23
申请号：EP94930665
申请日：1994-10-07
申请人： UNIV MARYLAND
发明人： KAPER JAMES B , LEVINE MYRON M
IPC分类号： C12N15/09 , A61K39/106 , A61P31/04 , C07K14/28 , C12N1/21 , C12N15/63 , C12P21/02 , C12R1/63 , C12N15/65 , C12N15/74
CPC分类号： A61K39/107 , A61K2039/522 , C07K14/28
摘要： Avirulent Vibrio cholerae strains of 01 (CVD111) and non-01 (CVD112 and CVD112RM) serogroups having the DNA of the cholera toxin core and the RS1 sequences of the cholera toxin locus deleted, and further having a DNA encoding a resistance to mercury, and a DNA encoding the cholera toxin B subunit, or a part thereof sufficient to confer immunogenicity, re-inserted in the chromosome. Methods of making the avirulent V. cholerae 01 and non-01 strains of the invention, and cholera vaccines using these strains.
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