公开(公告)号：EP3160949A4

公开(公告)日：2018-01-17

申请号：EP15811581

申请日：2015-06-26

申请人： UNIV MONASH ,  UNIV SOUTH AUSTRALIA ,  CENTRAL ADELAIDE LOCAL HEALTH NETWORK INCORPORATED

发明人： FLYNN BERNARD LUKE ,  AURELIO LUIGI ,  SCULLINO CARMEN VITTORIA ,  WANG BING HUI ,  PITSON STUART MAXWELL ,  PITMAN MELISSA ROSE

IPC分类号： C07D413/10 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/433 ,  A61K31/435 ,  A61P35/04 ,  C07D271/07 ,  C07D271/10 ,  C07D271/113 ,  C07D277/56 ,  C07D285/08 ,  C07D413/12 ,  C07D419/12

CPC分类号： C07D285/08 ,  C07D271/06 ,  C07D271/07 ,  C07D271/10 ,  C07D271/107 ,  C07D271/113 ,  C07D277/56 ,  C07D285/135 ,  C07D413/10 ,  C07D413/12 ,  C07D419/12

摘要： The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact with one or more enzymes in the sphingolipid biosynthesis pathway. The disclosure further relates to the use of such compounds as research tools, use in therapy, to compositions and agents comprising said compounds, and to methods of treatment using said compounds.