公开(公告)号：EP2139515A4

公开(公告)日：2011-07-06

申请号：EP08799746

申请日：2008-03-31

申请人： UNIV NEW YORK STATE RES FOUND

发明人： WIMMER ECKARD ,  SKIENA STEVE ,  MUELLER STEFFEN ,  FUTCHER BRUCE ,  PAPAMICHAIL DIMITRIS ,  COLEMAN JOHN ROBERT ,  CELLO JERONIMO

IPC分类号： A61K39/13

CPC分类号： C12N7/00 ,  A61K39/13 ,  A61K39/145 ,  A61K2039/5254 ,  C07K14/005 ,  C12N2720/12361 ,  C12N2740/15061 ,  C12N2760/16061 ,  C12N2760/16121 ,  C12N2760/16134 ,  C12N2760/16162 ,  C12N2770/20061 ,  C12N2770/24161 ,  C12N2770/32061 ,  C12N2770/32621 ,  C12N2770/32634 ,  C12N2770/32661 ,  C12N2770/32662 ,  C12N2770/32671 ,  C12N2770/32721 ,  C12N2770/32761 ,  C12N2770/32762

摘要： This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.

公开(公告)号：EP3189136A4

公开(公告)日：2018-04-04

申请号：EP15838658

申请日：2015-09-08

申请人： UNIV NEW YORK STATE RES FOUND

发明人： WIMMER ECKARD ,  MUELLER STEFFEN ,  FUTCHER BRUCE ,  SHEN SAM ,  STAUFT CHARLES ,  WARD CHARLES

IPC分类号： C12N7/00 ,  A01N65/00 ,  A61K39/12 ,  C12N7/01

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5254 ,  C12N2760/12234 ,  C12N2760/12262 ,  C12N2760/20062 ,  C12N2770/24121 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24162 ,  C12N2800/22

摘要： This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein encoding sequence relative to a first host while the codon pair bias relative to a second host is not substantially reduced. In another embodiment, the invention provides an attenuated virus comprising modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein-encoding sequence relative to a first host and a second host. The attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the attenuated virus.

公开(公告)号：EP2969005A4

公开(公告)日：2016-11-30

申请号：EP14763039

申请日：2014-03-15

申请人： UNIV NEW YORK STATE RES FOUND

发明人： MUELLER STEFFEN ,  WIMMER ECKARD ,  FUTCHER BRUCE ,  SKIENA STEVEN ,  YANG CHEN

IPC分类号： A61P31/16 ,  C12N7/04

CPC分类号： C12N7/00 ,  A61K39/145 ,  C12N2760/16034 ,  C12N2760/16061 ,  C12N2760/16134 ,  C12N2760/16162

摘要： This invention provides highly attenuated influenza viruses and vaccines. The attenuated viruses and vaccines proliferate well and have high safety factors. The attenuated viruses providing protective immunity from challenge by virus of the same subtype, as well as cross protection against heterologous viruses.

摘要翻译： 本发明提供高度减毒的流感病毒和疫苗。 减毒病毒和疫苗增殖良好，安全性高。 减毒病毒提供保护性免疫以免受相同亚型的病毒攻击，以及针对异源病毒的交叉保护。