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公开(公告)号：EP0754009A4
公开(公告)日：1999-10-20
申请号：EP95916198
申请日：1995-04-04
发明人： BALAMORE DILIP , CATES GORDON D JR , DRIEHUYS BASTIAAN , HAPPER WILLIAM , SAAM BRIAN , WISHNIA ARNOLD , ALBERT MITCHELL S
CPC分类号： G01R33/5601 , A61K49/1806 , A61K49/1815 , G01R33/282 , Y10T436/24
摘要： A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of the noble gas. The noble gas is selected from noble gas isotopes having nuclear spin, preferably Xenon-129 and/or Helium-3. The noble gas is at least thermally or equilibrium polarized and is preferably hyperpolarized, most preferably hyperpolarized by optical (laser) pumping in the presence of an alkali metal or by metastability exchange. The generation of the representation of the noble gas spatial distribution includes at least one dimension, preferably 2 or 3 dimensions of the spatial distribution. The noble gas may be imaged according to the invention in chemical or biological systems, preferably in a human or animal subject or organ system or tissue thereof. Also, apparatus for nuclear magnetic resonance imaging of the spatial distribution of at least one noble gas includes means for imaging a noble gas by NMR spectrometry and means for providing and/or storing imageable quantities of a noble gas, preferably hyperpolarized Xenon-129 and/or Helium-3. Also, a medical composition includes a medically acceptable bifunctional gas effective for in vivo anesthesiological and NMR imaging functions, including at least one noble gas, preferably hyperpolarized Xenon-129 and/or Helium-3.
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公开(公告)号：EP1015086A4
公开(公告)日：2004-11-17
申请号：EP98940943
申请日：1998-08-17
申请人： UNIV PRINCETON
CPC分类号： G01R33/282
摘要： The present invention relates to a method and apparatus for hyperpolarizing a noble gas by spin-exchange optical pumping which includes a polarization cell containing the noble gas, a primary alkali metal and an auxiliary alkali metal. The polarization cell is illuminated with radiation to optically polarize the primary alkali metal. This enables spin-exchange interaction between the primary alkali metal, the auxiliary alkali metal and the noble gas resulting in a hyperpolarized noble gas.
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公开(公告)号：EP0837641A4
公开(公告)日：2002-07-17
申请号：EP96918293
申请日：1996-06-07
申请人： UNIV PRINCETON
IPC分类号： G01R33/26 , A61B5/055 , A61K49/18 , B65D25/14 , C01B23/00 , C09D5/00 , C09D123/00 , C09D125/06 , C09D183/05 , C09D201/00 , F17C1/16 , G01N24/12 , G01R33/28 , C08G77/12 , A47G19/22 , B05D3/00 , B32B1/08 , B32B9/00 , B32B17/06 , C08L83/04 , C09D183/04
CPC分类号： G01R33/282 , A61K49/1815 , B65D25/14 , C01B23/00 , F17C1/16 , F17C2203/0607 , F17C2221/07 , F17C2270/0536 , Y10T428/1321 , Y10T428/31612
摘要： The invention provides a method of inhibiting surface-induced nuclear spin relaxation and surface trapping of a hyperpolarized noble gas, most preferably Xe, by polymercoated surfaces. The method includes inhibiting the amount of interaction of the noble gas with a polymeric coating on the surface of apparatus which contacts the noble gas. Preferably, the method includes inhibiting noble gas nuclear spin relaxation by replacing at least some of the protons in the polymer with substituents which have non-zero nuclear spin and/or reduced polymer permeability. A preferred substituent having non-zero spin is deuterium. A preferred modification which reduces permeability includes introducing into the polymer a substituent such as a halogen, more preferably fluorine. The method also provides containers having surfaces which have been coated with a polymer which inhibits noble gas trapping and nuclear spin relaxation. Furthermore, the invention provides methods for enhancing the production and storage of a hyperpolarized noble gas by decreasing the relaxation of nuclear spin and limiting the trapping of the noble gas in a polymeric coating of apparatus containing the noble gas.
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公开(公告)号：EP1036339A4
公开(公告)日：2000-09-20
申请号：EP98939394
申请日：1998-08-13
申请人： UNIV PRINCETON
CPC分类号： G01R33/282 , A61K49/1815 , G01R33/30 , Y10T428/1317
摘要： The present invention relates to a polarization cell which is coated with glass deposited from a sol-gel used for hyperpolarizing noble gases. The invention also includes a method for hyperpolarizing noble gases utilizing the polarization cell coated with glass deposited from a sol-gel. These polarization cells can also be incorporated into containers used for storage and transport of the hyperpolarized noble gases.
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公开(公告)号：EP0896655A4
公开(公告)日：2000-07-12
申请号：EP97917681
申请日：1997-03-27
申请人： UNIV PRINCETON
发明人： CATES GORDON D JR , DRIEHUYS BASTIAN , HAPPER WILLIAM , MIRON ELI , SAAM BRIAN , WALTER DANIEL , MIDDLETON HUNTER
CPC分类号： G01R33/282 , A61K49/1815 , Y10S62/919 , Y10S62/925
摘要： A method and apparatus for hyperpolarization of flowing noble gases is disclosed. The apparatus is capable of hyperpolarizing noble gases in a continuous flow arrangement. Noble gases such as xenon-129 and helium-3 can be hyperpolarized using the disclosed method and apparatus. Preferably, the noble gas is hyperpolarized via spin exchange between atoms of the noble gas and an alkali metal such as rubidium. Also, a method and apparatus for accumulation (17) and/or storage of hyperpolarized noble gases in a continuous flow arrangement is provided. The method and apparatus enable large scale production, storage, and usage of hyperpolarized noble gases for numerous purposes, including imaging of human and animal subjects through magnetic resonance imaging (MRI) techniques.
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公开(公告)号：EP0890066A4
公开(公告)日：2000-01-19
申请号：EP97917656
申请日：1997-03-27
申请人： UNIV PRINCETON
发明人： CATES GORDON D JR , DRIEHUYS BASTIAAN , HAPPER WILLIAM , MIRON ELI , SAAM BRIAN , WALTER DANIEL
CPC分类号： G01R33/282 , A61K49/1815 , C01B23/0036 , C01B2210/0037 , F25J3/0685 , F25J2205/20 , F25J2210/42 , F25J2215/36 , F25J2270/60 , F25J2270/904 , F25J2290/62 , H05H3/02 , Y10S62/919 , Y10S62/925
摘要： A method and apparatus for accumulation of hyperpolarized 129X e is disclosed. The method and apparatus of the invention enable the continuous or episodic accumulation of flowing hyperpolarized 129Xe in frozen form. The method also permits the accumulation of hyperpolarized 129Xe. The invention further includes 129Xe accumulation means (17) which is integrated with 129Xe hyperpolarization means in a continuous or pulsed flow arrangement. The method and apparatus enable large scale production, storage, and usage of hyperpolarized 129Xe for numerous purposes, including imaging of human and animal subjects through magnetic resonance imaging (MRI) techniques.
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