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公开(公告)号：EP2971162A4
公开(公告)日：2016-11-16
申请号：EP14770497
申请日：2014-03-14
申请人： UNIV TEXAS , BETH ISRAEL HOSPITAL
发明人： KALLURI RAGHU , MELO SONIA
CPC分类号： C12N15/113 , C07K14/4703 , C12N2310/14 , C12N2310/141 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178 , G01N33/57488 , G01N2333/4704 , G06F19/18 , Y02A90/26
摘要： Methods for diagnosis and treatment of cancers by use of exosomes comprising miRNAs and precursors thereof. For example, in some aspects, a cancer may be diagnosed or evaluated by determining the miRNA content of exosomes in a sample from a subject or by detecting miRNA processing in exosomes.
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公开(公告)号：EP1773349A4
公开(公告)日：2009-07-29
申请号：EP05779072
申请日：2005-05-04
发明人： FOLKMAN JUDAH , KALLURI RAGHU
CPC分类号： A61K31/56
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3.发明公开HYPOXIA RELATED GENES AND PROTEINS FOR THE TREATMENT AND DIAGNOSIS OF PREGNANCY RELATED COMPLICATIONS 审中-公开用于治疗和诊断妊娠并发症缺氧相关基因和蛋白质
公开(公告)号：EP2099933A4
公开(公告)日：2010-03-24
申请号：EP07873702
申请日：2007-11-21
申请人： BETH ISRAEL HOSPITAL
发明人： KALLURI RAGHU
CPC分类号： G01N33/689 , G01N2800/368
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公开(公告)号：EP3076949A4
公开(公告)日：2017-11-22
申请号：EP14867768
申请日：2014-12-04
申请人： UNIV TEXAS
发明人： KALLURI RAGHU , MELO SONIA
IPC分类号： G01N33/574
CPC分类号： G01N33/57488 , A61K9/5068 , A61K35/12 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N2333/705
摘要： The present invention provides that exosomes from human body fluid samples contain double stranded genomic DNA that spans all chromosomes and may be used to determine the mutation status of genes of interest in diseases, such as cancer. Furthermore, the present invention provides the use of exosomes to produce therapeutic proteins and for their use in therapy as well as the detection of cancer cell-derived exosomes to diagnose cancer and monitor therapeutic response.
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