公开(公告)号：EP0576623A4

公开(公告)日：1995-01-18

申请号：EP92911557

申请日：1992-05-01

申请人： UNIV YALE ,  INDIANA UNIVERSITY FOUNDATION

发明人： ARTAVANIS-TSAKONAS SPYRIDON ,  MUSKAVITCH MARC ALAN TELANDER ,  FEHON RICHARD GRANT ,  REBAY ILARIA ,  BLAUMUELLER CHRISTINE MARIE ,  SHEPARD SCOTT BROCKEWELL

IPC分类号： C12N15/09 ,  A61K38/00 ,  C07K14/47 ,  C07K14/485 ,  C07K14/52 ,  C07K14/705 ,  C07K16/00 ,  C07K16/18 ,  C07K19/00 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  C07K13/00 ,  C12N15/63 ,  C12P21/00

CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  Y10S530/839

摘要： The present invention relates to nucleotide sequences of the human Notch and Delta genes, and amino acid sequences of their encoded proteins, as well as fragments thereof containing an antigenic determinant or which are functionally active. The invention is also directed to fragments (termed herein "adhesive fragments"), and the sequences thereof, of the proteins ("toporythmic proteins") encoded by toporythmic genes which mediate homotypic or heterotypic binding to toporythmic proteins. Toporythmic genes, as used herein, refers to the genes Notch, Delta and Serrate, as well as other members of the Delta/Serrate family which may be identified, e.g., by the methods described herein. Antibodies to human Notch and to adhesive fragments are additionally provided.