公开(公告)号：EP2505220A2

公开(公告)日：2012-10-03

申请号：EP12004762.6

申请日：2008-06-25

申请人： UNIVERSITY COLLEGE LONDON

发明人： Selden, Clare ,  Hodgson, Humphrey ,  Coward, Sam

IPC分类号： A61M1/36 ,  A01N1/02 ,  C12M1/00 ,  C12M3/00 ,  A61M1/34

CPC分类号： A01N1/0247 ,  A01N1/02 ,  A01N1/0257 ,  A61F2/022 ,  A61M1/3472 ,  A61M1/3489 ,  A61M1/3689 ,  C12M21/08 ,  C12M23/06 ,  C12M25/16 ,  C12M29/04 ,  C12M41/24 ,  C12N5/0671 ,  C12N2511/00 ,  C12N2533/12 ,  C12N2533/74

摘要： The present invention relates to the field of extracorporeal liver perfusion and, more particularly, to a method of proliferating human hepatocyte derived cells. It comprises;
a) Seeding cells into a matrix forming agent;
b) Pre-culturing the matrix encapsulated cells so that they form cohesive spheroids and;
c) Growing them to performance competence.

摘要翻译： 本发明涉及体外肝灌注领域，更具体地说，涉及一种增殖人肝细胞衍生细胞的方法。 它包括 a）将细胞接种到基质成形剂中; b）预培养基质包封的细胞，使其形成凝聚的球状体; c）使他们成长为表现能力。

公开(公告)号：EP2505220A3

公开(公告)日：2013-05-01

申请号：EP12004762.6

申请日：2008-06-25

申请人： UNIVERSITY COLLEGE LONDON

发明人： Selden, Clare ,  Hodgson, Humphrey ,  Coward, Sam

IPC分类号： A61M1/36 ,  A01N1/02 ,  C12M1/00 ,  C12M3/00 ,  C12N5/071 ,  A61M1/34

CPC分类号： A01N1/0247 ,  A01N1/02 ,  A01N1/0257 ,  A61F2/022 ,  A61M1/3472 ,  A61M1/3489 ,  A61M1/3689 ,  C12M21/08 ,  C12M23/06 ,  C12M25/16 ,  C12M29/04 ,  C12M41/24 ,  C12N5/0671 ,  C12N2511/00 ,  C12N2533/12 ,  C12N2533/74

摘要： The present invention relates to the field of extracorporeal liver perfusion and, more particularly, to a method of proliferating human hepatocyte derived cells. It comprises;
a) Seeding cells into a matrix forming agent;
b) Pre-culturing the matrix encapsulated cells so that they form cohesive spheroids and;
c) Growing them to performance competence.

公开(公告)号：EP2505220B1

公开(公告)日：2018-01-24

申请号：EP12004762.6

申请日：2008-06-25

申请人： UNIVERSITY COLLEGE LONDON

发明人： Selden, Clare ,  Hodgson, Humphrey ,  Coward, Sam

IPC分类号： A61M1/36 ,  A01N1/02 ,  C12M1/00 ,  C12M3/00 ,  C12N5/071 ,  A61M1/34

CPC分类号： A01N1/0247 ,  A01N1/02 ,  A01N1/0257 ,  A61F2/022 ,  A61M1/3472 ,  A61M1/3489 ,  A61M1/3689 ,  C12M21/08 ,  C12M23/06 ,  C12M25/16 ,  C12M29/04 ,  C12M41/24 ,  C12N5/0671 ,  C12N2511/00 ,  C12N2533/12 ,  C12N2533/74

摘要： The present invention relates to the field of extracorporeal liver perfusion and, more particularly, to a method of proliferating human hepatocyte derived cells. It comprises; a) Seeding cells into a matrix forming agent; b) Pre-culturing the matrix encapsulated cells so that they form cohesive spheroids and; c) Growing them to performance competence.