-
公开(公告)号：EP0821583A1
公开(公告)日：1998-02-04
申请号：EP95927480.0
申请日：1995-07-26
CPC分类号： A61K31/711 , A61K9/1652 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/15 , A61K48/00 , A61K2039/53 , A61K2039/54 , A61K2039/58 , C07K14/005 , C12N15/87 , C12N2720/12322 , C12N2720/12334 , C12N2740/15022 , C12N2740/16122 , C12N2760/16122
摘要： This invention relates to DNA vaccines for eliciting an immune response and/or protective immunity in a vertebrate by introducing into the vertebrate the DNA vaccine which consists essentially of DNA encoding an antigen or antigens, e.g. capsid proteins or polypeptides, of rotavirus. The uptake of the DNA vaccine by a host vertebrate results in the expression of the capsid protein, thereby eliciting humoral or cell-mediated immune responses, or both, which can provide protection against infection and/or prevent clinically significant rotavirus-caused disease. In addition, the invention demonstrates that an internal viral antigen provides protective immunity in a host. The host can be any vertebrate, including birds, piglets, and humans.
-
公开(公告)号：EP0821583B1
公开(公告)日：2000-10-04
申请号：EP95927480.4
申请日：1995-07-26
CPC分类号： A61K31/711 , A61K9/1652 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/15 , A61K48/00 , A61K2039/53 , A61K2039/54 , A61K2039/58 , C07K14/005 , C12N15/87 , C12N2720/12322 , C12N2720/12334 , C12N2740/15022 , C12N2740/16122 , C12N2760/16122
摘要： This invention relates to DNA vaccines for eliciting an immune response and/or protective immunity in a vertebrate by introducing into the vertebrate the DNA vaccine which consists essentially of DNA encoding an antigen or antigens, e.g. capsid proteins or polypeptides, of rotavirus. The uptake of the DNA vaccine by a host vertebrate results in the expression of the capsid protein, thereby eliciting humoral or cell-mediated immune responses, or both, which can provide protection against infection and/or prevent clinically significant rotavirus-caused disease. In addition, the invention demonstrates that an internal viral antigen provides protective immunity in a host. The host can be any vertebrate, including birds, piglets, and humans.
-
公开(公告)号：EP0633937A1
公开(公告)日：1995-01-18
申请号：EP93907536.0
申请日：1993-03-17
IPC分类号： A61K48 , A61K9 , A61K35 , A61K39 , A61P15 , A61P31 , A61P33 , A61P35 , C07K14 , C12N15 , A61K38 , C12R1
CPC分类号： C12N15/86 , A61K9/1652 , A61K31/711 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/21 , A61K48/00 , A61K2039/51 , A61K2039/53 , A61K2039/543 , A61K2039/545 , C07K14/005 , C12N15/87 , C12N2720/12322 , C12N2740/11043 , C12N2740/13043 , C12N2740/15022 , C12N2740/16122 , C12N2760/16122 , C12N2760/16134 , C12N2800/24
摘要： This invention relates to a method of immunizing a vertebrate, comprising introducing into the vertebrate a DNA transcription unit which comprises DNA encoding a desired antigen or antigens. The uptake of the DNA transcription unit by a host vertebrate results in the expression of the desired antigen or antigens, thereby eliciting humoral or cell-mediated immune responses or both humoral and cell-mediated responses. The elicited humoral and cell-mediated immune response can provide protection against infection by pathogenic agents, provide an anti-tumor response, or provide contraception. The host can be any vertebrate, avian or mammal, including humans.
-
-
搜索结果
3 条记录 (耗时 0.01 秒)
