公开(公告)号：EP4175633A1

公开(公告)日：2023-05-10

申请号：EP21740607.3

申请日：2021-07-02

申请人： Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. ,  B.S.R.C. "Alexander Fleming"

发明人： AIDINIS, Vassilios ,  MATRALIS, Alexios

IPC分类号： A61K31/4162 ,  A61K31/4439 ,  A61K31/497 ,  A61P11/00 ,  A61P35/00

公开(公告)号：EP2575794A2

公开(公告)日：2013-04-10

申请号：EP11726091.9

申请日：2011-06-03

申请人： B.S.R.C. "Alexander Fleming"

发明人： AIDINIS, Vassilios

IPC分类号： A61K31/047 ,  A61K31/122 ,  A61K31/137 ,  A61K31/185 ,  A61K31/352 ,  A61K31/4035 ,  A61K31/4174 ,  A61K31/421 ,  A61K31/435 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/519 ,  A61K31/655 ,  A61K31/661 ,  A61K31/662

CPC分类号： A61K39/3955 ,  A61K31/047 ,  A61K31/122 ,  A61K31/137 ,  A61K31/185 ,  A61K31/198 ,  A61K31/352 ,  A61K31/4035 ,  A61K31/4174 ,  A61K31/421 ,  A61K31/435 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/519 ,  A61K31/655 ,  A61K31/661 ,  A61K31/662 ,  A61K31/664 ,  A61K31/665 ,  A61K38/465 ,  A61K39/395 ,  A61K45/06 ,  C07K16/40 ,  C12Q1/34 ,  C12Q1/44 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/564 ,  G01N33/574 ,  G01N2333/916 ,  G01N2800/102 ,  G01N2800/12 ,  G01N2800/26 ,  G01N2800/285 ,  A61K2300/00

摘要： Disclosed are methods for preventing, treating, or reducing symptoms of a disorder involving the autotaxin (ATX) pathway. In one embodiment, the method features administering to a mammal a sufficient amount of an autotaxin (ATX) or lysophosphatidic acid (LPA) signaling inhibitor, to prevent, treat or reduce symptoms of an inflammatory disorder, autoimmune disorder, fibrosis or malignancy of the lung. Further disclosed are methods for diagnosing an autotaxin-related disorder as well as kits for performing the methods of the invention.

摘要翻译： 公开了用于预防，治疗或减轻涉及autotaxin（ATX）途径的病症症状的方法。 在一个实施方案中，所述方法特征在于向哺乳动物施用足量的自分泌素（ATX）或溶血磷脂酸（LPA）信号传导抑制剂以预防，治疗或减轻肺部的炎性病症，自身免疫病症，纤维化或恶性肿瘤的症状 。 进一步公开了诊断自体趋化蛋白相关病症的方法以及用于实施本发明方法的试剂盒。

公开(公告)号：EP1941273A2

公开(公告)日：2008-07-09

申请号：EP06806493.0

申请日：2006-10-19

申请人： B.S.R.C. "Alexander Fleming" ,  RIKEN

发明人： KOLLIAS, Georgios ,  AIDINIS, Vassilios ,  HAYASHIZAKI, Yoshishide ,  CARNINCI, Piero

IPC分类号： G01N33/50

CPC分类号： A01K67/0275 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/0368 ,  C07K14/525 ,  C12N15/8509 ,  G01N33/6872

摘要： The invention provides means and methods for determining whether a sample is derived from an individual suffering from inflammatory arthritis or from an individual at risk of suffering there from, said method comprising measuring in said sample the level of expression of at least one gene product of a gene of table A, table B or and comparing said expression level with a reference value. Further provided is a non-human animal model comprising an altered expression of a gene of table A, table B or when compared to a reference non-human animal, and use of this model as or in an arthritis model. Further provided is an in vitro assay for screening compounds for effect on a phenotype of synovial fibroblasts. The synovial fibroblast are preferably derived from a human or non-human animal suffering from inflammatory arthritis.