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公开(公告)号：EP3492917A1
公开(公告)日：2019-06-05
申请号：EP18215184.5
申请日：2004-03-31
IPC分类号： G01N33/543
摘要： The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in anyone microcapsule; and b) identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
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公开(公告)号：EP3492916A1
公开(公告)日：2019-06-05
申请号：EP18215126.6
申请日：2004-03-31
IPC分类号： G01N33/543
摘要： The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in anyone microcapsule; and b) identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
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公开(公告)号：EP3524344A1
公开(公告)日：2019-08-14
申请号：EP19158398.8
申请日：2004-03-31
IPC分类号： B01J19/00 , G01N33/543 , C07K1/04 , C12N15/10 , C40B20/04 , C40B30/04 , C40B50/08 , B82Y30/00 , B82Y10/00 , B82Y5/00 , C40B40/06 , C40B40/10
摘要： The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.
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