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公开(公告)号：EP3619226A2
公开(公告)日：2020-03-11
申请号：EP18726744.8
申请日：2018-05-07
申请人： Universitat Autònoma de Barcelona , Fundació Institut de recerca de l'Hospital de la Santa Creu i Sant Pau , Centro en Investigación Biomédica en Red
发明人： VILLAVERDE CORRALES, Antonio , VÁZQUEZ GÓMEZ, Esther , SERNA ROMERO, Naroa , SÁNCHEZ GARCÍA, Laura , UNZUETA ELORZA, Ugutz , MANGUES BAFALLUY, Ramón , CÉSPEDES NAVARRO, María Virtudes , CASANOVA RIGAT, Isolda
IPC分类号： C07K14/435 , A61K38/10 , C12N15/62
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公开(公告)号：EP3427756A1
公开(公告)日：2019-01-16
申请号：EP17382461.6
申请日：2017-07-14
申请人： Universitat Autónoma De Barcelona (UAB) , Fundació Institut de Recerca de l'Hospital de la Santa creu i Sant Pau , Centro en Investigación Biomédica en Red
发明人： VILLAVERDE CORRALES, Antonio , VÁZQUEZ GÓMEZ, Esther , UNZUETA ELORZA, Ugutz , MANGUES BAFALLUY, Ramon , CÉSPEDES NAVARRO, María Virtudes , CASANOVA RIGAT, Isolda
摘要： The present invention relates to nanostructured conjugates, more specifically to nanostructured fusion proteins suitable for the selective delivery of their conjugated therapeutic agents to specific cell and tissue types. It also relates to nanoparticles comprising such nanostructured proteins and the therapeutic uses thereof.
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3.发明授权METHODS AND REAGENTS FOR EFFICIENT AND TARGETED DELIVERY OF THERAPEUTIC MOLECULES TO CXCR4 CELLS 有权有效和有针对性地将治疗性分子递送至CXCR4细胞的方法和试剂
公开(公告)号：EP2663336B1
公开(公告)日：2017-08-09
申请号：EP12704711.6
申请日：2012-01-13
申请人： Universitat Autònoma de Barcelona , Fundacio Institut de Recerca de l'Hospital de la Santa Creu i sant Pau , Centro de Investigación Biomédica en Red
发明人： VILLAVERDE CORRALES, Antonio , VÁZQUEZ GÓMEZ, Esther , CÉSPEDES NAVARRO, María Virtudes , CASANOVA RIGAT, Isolda , FERRER MIRALLES, Neus , MANGUES BAFALLUY, Ramon , UNZUETA ELORZA, Ugutz
IPC分类号： A61K47/50 , C07K14/435 , C12N15/62
摘要： The invention relates to conjugates comprising a targeting moiety specific for the CXCR4 based on the polyphemusin-derived peptide and a therapeutic or imaging agent. The invention relates as well to the application of said conjugates for the therapy and diagnostics which require the specific targeting to CXCR4+ cells.
摘要翻译： 本发明涉及包含基于聚肌球蛋白衍生肽的CXCR4特异性靶向部分和治疗剂或成像剂的缀合物。 本发明还涉及所述缀合物用于需要对CXCR4 +细胞进行特异性靶向的治疗和诊断的应用。
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4.发明公开METHODS AND REAGENTS FOR EFFICIENT AND TARGETED DELIVERY OF THERAPEUTIC MOLECULES TO CXCR4 CELLS 有权方法和试剂细胞CXCR4治疗性分子在高效，靶向给药
公开(公告)号：EP2663336A1
公开(公告)日：2013-11-20
申请号：EP12704711.6
申请日：2012-01-13
申请人： Universitat Autònoma De Barcelona , Institut Recerca Hospital de la Santa Creu i Sant Pau , Centro Investigación Biomédica en Red (Ciber BBN)
发明人： VILLAVERDE CORRALES, Antonio , VÁZQUEZ GÓMEZ, Esther , CÉSPEDES NAVARRO, María Virtudes , CASANOVA RIGAT, Isolda , FERRER MIRALLES, Neus , MANGUES BAFALLUY, Ramon , UNZUETA ELORZA, Ugutz
IPC分类号： A61K47/48 , C07K14/435 , C12N15/62
摘要： The invention relates to conjugates comprising a targeting moiety specific for the CXCR4 based on the polyphemusin-derived peptide and a therapeutic or imaging agent. The invention relates as well to the application of said conjugates for the therapy and diagnostics which require the specific targeting to CXCR4+ cells.
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公开(公告)号：EP4081538A1
公开(公告)日：2022-11-02
申请号：EP21701052.9
申请日：2021-01-11
申请人： Universitat Autònoma de Barcelona , Nanoligent, S.L. , Consorcio Centro de Investigación Biomédica en Red , Fundacio Institut de Recerca de l'Hospital de la Santa Creu i sant Pau
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公开(公告)号：EP3953368A1
公开(公告)日：2022-02-16
申请号：EP20736248.4
申请日：2020-04-08
申请人： Universitat Autònoma de Barcelona , Institut Recerca Hospital de la Santa Creu I Sant Pau , Consorcio Centro de Investigación Biomédica en Red, M.P. (CIBER)
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7.发明公开INCLUSION BODIES, BACTERIAL CELLS AND COMPOSITIONS CONTAINING THEM AND USES THEREOF 审中-公开包容性，细菌细胞和含有组合物及其
公开(公告)号：EP2377946A1
公开(公告)日：2011-10-19
申请号：EP09836114.0
申请日：2009-12-22
申请人： Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER BBN) , Universitat Autònoma De Barcelona , Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER BBN)
发明人： VECIANA MIRO, Jaume , RATERA BASTARDAS, Inmaculada , DÍEZ GIL, César , VILLAVERDE CORRALES, Antonio Pedro , VÁZQUEZ GÓMEZ, Esther , GARCÍA FRUITÓS, Elena
CPC分类号： C12P21/02 , A61K38/162 , C07K2319/60 , Y10T428/2982
摘要： The present invention refers to an isolated inclusion body comprising a polypeptide characterised in that the inclusion body is particulate in form. The present invention also refers to a bacterial cell comprising said inclusion body. The present invention additionally refers to a composition comprising said inclusion body and a eukaryotic cell. The present invention also refers to a composition comprising said inclusion body and an animal or plant tissue. The present invention also refers to the uses of said inclusion bodies as medicines and stimulators of cell proliferation and tissue regeneration.
摘要翻译： 本发明涉及分离的包涵体的包含多肽DASS包涵体在形式颗粒。因此，本发明涉及一种细菌细胞包含所述包涵体。 另外，本发明是指包含所述包涵体和真核细胞的组合物。 因此，本发明涉及包含所述包涵体和动物或植物组织的组合物。 因此，本发明涉及到所述包涵体作为药物和细胞增殖和组织再生的刺激的用途。
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