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公开(公告)号：EP1470218A2
公开(公告)日：2004-10-27
申请号：EP02738952.7
申请日：2002-05-17
发明人： ROTTIER, Petrus, Josephus, Marie , DE HAAN, Cornelis, Alexander, Maria , HAIJEMA, Bert, Jan , BOSCH, Berend, Jan
IPC分类号： C12N7/04 , C12N15/86 , A61K39/215 , A61K39/225 , C07K14/165
CPC分类号： A61K39/215 , A61K38/00 , A61K39/12 , A61K39/225 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/12034 , C12N2710/16034 , C12N2740/13034 , C12N2750/14334 , C12N2760/16034 , C12N2770/20021 , C12N2770/20022 , C12N2770/20023 , C12N2770/20034 , C12N2770/20043 , C12N2800/204 , G01N33/56983 , G01N2333/165
摘要： The invention relates to the field of coronaviruses and diagnosis, therapeutic use and vaccines derived thereof. The invention provides replicative coronaviruses and replicative virus-like particles (VLPs) from which large parts of their genome are (at least functionally) deleted without abolishing their replicative capacities. Said deletion is preferably resulting in at least a functional deletion in that the corresponding gene is not or only partly expressed whereby the resulting gene product is dysfunctional or at least functionally distinct from a corresponding wild-type gene product. One striking result seen with VLPs provided with deletions as provided herein is that said deleted VLP, albeit capable of replication in vitro and in vivo, are in general well attenuated, in that they do not cause disease in the target host, making them very suitable for therapeutic use, said as a delivery vehicle for genes and other cargo (whereby specific targeting may be provided as well when desired), and for use as a vaccine, being attenuated while carrying important immunogenic determinants that help elicit an immune response.
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公开(公告)号：EP1470218B1
公开(公告)日：2010-07-07
申请号：EP02738952.7
申请日：2002-05-17
发明人： ROTTIER, Petrus, Josephus, Marie , DE HAAN, Cornelis, Alexander, Maria , HAIJEMA, Bert, Jan , BOSCH, Berend, Jan
IPC分类号： C12N7/04 , C12N15/86 , A61K39/215 , A61K39/225 , C07K14/165
CPC分类号： A61K39/215 , A61K38/00 , A61K39/12 , A61K39/225 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/12034 , C12N2710/16034 , C12N2740/13034 , C12N2750/14334 , C12N2760/16034 , C12N2770/20021 , C12N2770/20022 , C12N2770/20023 , C12N2770/20034 , C12N2770/20043 , C12N2800/204 , G01N33/56983 , G01N2333/165
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公开(公告)号：EP2555795B1
公开(公告)日：2016-07-13
申请号：EP11715069.8
申请日：2011-04-08
IPC分类号： A61K39/00 , A61K39/145 , C12N9/24 , A61K39/12
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5256 , A61K2039/552 , A61K2039/55566 , A61K2039/55577 , A61K2039/58 , A61K2039/70 , C07K2319/22 , C07K2319/73 , C12N9/2402 , C12N2760/16134 , C12N2760/18134 , C12N2760/18143 , C12N2770/20034 , C12Y302/01018
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公开(公告)号：EP2555795A1
公开(公告)日：2013-02-13
申请号：EP11715069.8
申请日：2011-04-08
IPC分类号： A61K39/145 , C07K14/11
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5256 , A61K2039/552 , A61K2039/55566 , A61K2039/55577 , A61K2039/58 , A61K2039/70 , C07K2319/22 , C07K2319/73 , C12N9/2402 , C12N2760/16134 , C12N2760/18134 , C12N2760/18143 , C12N2770/20034 , C12Y302/01018
摘要： The invention relates to immunogenic compositions comprising recombinant multimeric influenza proteins or parts thereof fused to a streptavidin affinity tag, preferably recombinant trimeric influenza virus hemagglutinin and/or recombinant tetrameric influenza virus neuraminidase, or vectors comprising nucleic acid sequences encoding such influenza proteins. The inventions further relate to methods for the preparation of such immunogenic compositions and uses thereof and methods for eliciting an immune response in an individual.
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