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1.发明公开PROGNOSTIC AND PREDICTIVE GENE SIGNATURE FOR NON-SMALL CELL LUNG CANCER AND ADJUVANT CHEMOTHERAPY 有权非小细胞肺癌和辅助化疗的预后和预后基因特征
公开(公告)号：EP2288741A1
公开(公告)日：2011-03-02
申请号：EP09745336.9
申请日：2009-05-14
发明人： TSAO, Ming-Sound , SHEPHERD, Frances, A. , JURISICA, Igor , DER, Sandy, D. , ZHU, Chang-Qi , STRUMPF, Dan , SEYMOUR, Lesley , DING, Keyue
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/57423 , G01N2800/52 , G06F19/00 , G06F19/20 , G06F19/24 , G16H50/30
摘要： The application provides methods of prognosing and classifying lung cancer patients into poor survival groups or good survival groups and for determining the benefit of adjuvant chemotherapy by way of a multigene signature. The application also includes kits and computer products for use in the methods of the application.
摘要翻译： 本申请提供了将肺癌患者预后并分类为不良存活组或良好存活组以及通过多基因标签确定辅助化疗的益处的方法。 该应用程序还包括用于应用程序方法的套件和计算机产品。
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2.发明授权PROGNOSTIC AND PREDICTIVE GENE SIGNATURE FOR NON-SMALL CELL LUNG CANCER AND ADJUVANT CHEMOTHERAPY 有权非小细胞肺癌和ADJUVANSCHEMOTHERAPIE预后和预测性基因印记
公开(公告)号：EP2288741B1
公开(公告)日：2015-01-28
申请号：EP09745336.9
申请日：2009-05-14
发明人： TSAO, Ming-Sound , SHEPHERD, Frances, A. , JURISICA, Igor , DER, Sandy, D. , ZHU, Chang-Qi , STRUMPF, Dan , SEYMOUR, Lesley , DING, Keyue
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/57423 , G01N2800/52 , G06F19/00 , G06F19/20 , G06F19/24 , G16H50/30
摘要： The application provides methods of prognosing and classifying lung cancer patients into poor survival groups or good survival groups and for determining the benefit of adjuvant chemotherapy by way of a multigene signature. The application also includes kits and computer products for use in the methods of the application.
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公开(公告)号：EP2663672A1
公开(公告)日：2013-11-20
申请号：EP12734694.8
申请日：2012-01-11
IPC分类号： C40B40/06 , A61K45/06 , C12Q1/68 , C40B30/04 , C40B40/10 , G01N33/53 , G01N33/574 , C07H21/00
CPC分类号： C12Q1/6886 , A61N5/00 , C12Q2600/118 , C12Q2600/158 , G01N33/57407 , G01N33/6893 , G01N2800/14 , G01N2800/18 , G01N2800/50 , G01N2800/60
摘要： The present disclosure describes methods and compositions for diagnosing or predicting likelihood of a OSCC recurrence in a subject having undergone OSCC resection comprising: a) determining an expression level of one or more biomarkers selected from Table 4, 5 and/or 7, optionally MMP1, COL4A1, THBS2 and/or P4HA2 in a test sample from the subject, the one or more biomarkers comprising at least one of THBS2 and P4HA2, and b) comparing the expression level of the one or more biomarkers with a control, wherein a difference or a similarity in the expression level of the one or more biomarkers between the test sample and the control is used to diagnose or predict the likelihood of OSCC recurrence in the subject In particular, the present disclosure describes methods and compositions using a four-gene biomarker signature that can predict recurrence of oral squamous cell carcinoma in subjects that have histologically normal surgical resection margins.
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