公开(公告)号：EP2861720A1

公开(公告)日：2015-04-22

申请号：EP13732409.1

申请日：2013-06-19

申请人： University Of Pennsylvania ,  Katholieke Universiteit Leuven

发明人： CHEN, Christopher ,  LUYTEN, Frank ,  EYCKMANS, Jeroen ,  SCHROOTEN, Jan ,  ROBERTS, Scott

IPC分类号： C12N5/071

CPC分类号： C12N5/0654 ,  A61K35/12 ,  A61K45/06 ,  C12N2500/14 ,  C12N2500/38 ,  C12N2501/11 ,  C12N2501/15 ,  C12N2501/2306 ,  C12N2501/25 ,  C12N2506/13 ,  C12N2506/1392

摘要： The present invention relates to methods and compositions for osteogenic differentiation of human periosteum derived cells, in particular using a growth medium containing a specific combination of growth factors and formulations thereof. The invention also relates to the differentiated cells and cell populations, as well as further products comprising such cells and uses thereof in bone therapy.

摘要翻译： 本发明涉及人骨膜衍生细胞成骨分化的方法和组合物，特别是使用含生长因子及其制剂的特定组合的生长培养基。 本发明还涉及分化的细胞和细胞群，以及包含这种细胞的其它产物及其在骨疗法中的用途。

公开(公告)号：EP3303556A1

公开(公告)日：2018-04-11

申请号：EP16727156.8

申请日：2016-05-27

申请人： Katholieke Universiteit Leuven

发明人： BLOEMEN, Veerle ,  BOLANDER, Johanna ,  LUYTEN, Frank

IPC分类号： C12N5/00 ,  C12N5/077

CPC分类号： A61K35/28 ,  A61P19/02 ,  A61P19/04 ,  A61P19/10 ,  C12N5/0012 ,  C12N5/0037 ,  C12N5/0654 ,  C12N5/0655 ,  C12N2500/25 ,  C12N2500/33 ,  C12N2500/38 ,  C12N2500/46 ,  C12N2500/98 ,  C12N2500/99 ,  C12N2501/155 ,  C12N2501/37 ,  C12N2501/39 ,  C12N2501/395 ,  C12N2506/1392 ,  C12N2513/00 ,  C12N2533/18 ,  C12N2533/54 ,  C12N2533/78

摘要： The application provides biocompatible carriers comprising bone forming and/or cartilage forming cells and methods for making them. The application further provides pharmaceutical compositions comprising said ATMPs and method of treatments using said ATMPs. The application further relates to said ATMPS for use in the treatment of bone disorders, cartilage disorders and joint disorders. The current invention further relates to method of treatments of bone disorders, cartilage disorders and joint disorders.

公开(公告)号：EP3630955A1

公开(公告)日：2020-04-08

申请号：EP18742930.3

申请日：2018-05-30

申请人： Katholieke Universiteit Leuven

发明人： LUYTEN, Frank ,  FREITAS MENDES, Luis ,  NILSSON HALL, Gabriella ,  PAPANTONIOU, Ioannis ,  GERIS, Liesbet

IPC分类号： C12N5/077 ,  C12N5/0775 ,  A61K35/32