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公开(公告)号：EP1007533B1
公开(公告)日：2005-06-22
申请号：EP97939382.4
申请日：1997-08-22
IPC分类号： C07H21/02 , C07H21/04 , C07H23/00 , G01N33/15 , A61K31/525 , A61K39/00 , A61K39/44 , A61K35/00 , A61K49/00 , A61K47/48
CPC分类号： C07H21/00 , A61K41/0028 , A61K41/0042 , A61K47/54
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公开(公告)号：EP1226153B1
公开(公告)日：2010-03-03
申请号：EP00973834.5
申请日：2000-10-26
CPC分类号： A61K49/0052 , A61B5/415 , A61B5/417 , A61B5/418 , A61K47/551 , A61K49/0013 , A61K49/0015 , A61K49/0041 , A61K49/0043 , C07F15/065 , C09K11/06 , G01N33/52 , G01N33/574 , G01N2800/52
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公开(公告)号：EP1226153A2
公开(公告)日：2002-07-31
申请号：EP00973834.5
申请日：2000-10-26
CPC分类号： A61K49/0052 , A61B5/415 , A61B5/417 , A61B5/418 , A61K47/551 , A61K49/0013 , A61K49/0015 , A61K49/0041 , A61K49/0043 , C07F15/065 , C09K11/06 , G01N33/52 , G01N33/574 , G01N2800/52
摘要： The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalamin. These fluorescent cobalamins can be used as diagnostic and prognostic markers (a) to distinguish cancer cells and tissues from healthy cells and tissues and (b) to determine if an individual will respond positively to chemotherapy using cobalamin-therapeutic bioconjugates.
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公开(公告)号：EP1007533A1
公开(公告)日：2000-06-14
申请号：EP97939382.4
申请日：1997-08-22
IPC分类号： C07H21/02 , C07H21/04 , C07H23/00 , G01N33/15 , A61K31/525 , A61K39/00 , A61K39/44 , A61K35/00 , A61K49/00
CPC分类号： C07H21/00 , A61K41/0028 , A61K41/0042 , A61K47/54
摘要： The present invention relates to bioconjugates and the delivery of bioactive agents which are preferably targeted for site-specific release in cells, tissues or organs. More particularly, this invention relates to bioconjugates which comprise of bioactive agent and an organocobalt complex. The bioactive agent is covalently bonded directly or indirectly to the cobalt atom of the oragnocobalt complex. The bioactive agent is released from the bioconjugate by the cleavage of the covalent bond between the bioactive agent and the cobalt atom in the oragnocobalt complex. The cleavage may occur as a result of normal displacment by cellular nucleophiles or enzymatic action, but is preferably caused to occur selectively at a predetermined release site by application of an external signal. The external signal may be light or photoexcitation, i.e. photolysis, or it may be ultrasound, i.e. sonolysis. Further, if the photolysis takes places in the presence of a magnetic field surrounding the release site, the release of the bioactive agent into surrounding healthy tissue is minimized.
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