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公开(公告)号：EP1226153B1
公开(公告)日：2010-03-03
申请号：EP00973834.5
申请日：2000-10-26
CPC分类号： A61K49/0052 , A61B5/415 , A61B5/417 , A61B5/418 , A61K47/551 , A61K49/0013 , A61K49/0015 , A61K49/0041 , A61K49/0043 , C07F15/065 , C09K11/06 , G01N33/52 , G01N33/574 , G01N2800/52
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2.发明授权
公开(公告)号：EP1370291B1
公开(公告)日：2010-06-16
申请号：EP02725145.3
申请日：2002-03-15
CPC分类号： A61K49/0032 , A61B1/00186 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B1/313 , A61B5/0071 , A61B5/0084 , A61B5/415 , A61B5/417 , A61B5/418 , A61B90/30 , A61B90/36 , A61B90/361 , A61B2090/3941 , A61K47/54 , A61K47/551 , A61K49/0041 , A61K49/0043 , A61K49/0052 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1044 , C09K2211/187 , G01N21/64 , G01N33/574 , G02B21/0012 , Y02B20/181
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公开(公告)号：EP1377220B1
公开(公告)日：2017-01-18
申请号：EP02728498.3
申请日：2002-03-15
CPC分类号： A61K49/0052 , A61B5/0071 , A61B5/0084 , A61B5/415 , A61B5/417 , A61B5/418 , A61B2090/3941 , A61K47/54 , A61K47/551 , A61K49/0032 , A61K49/0041 , A61K49/0043 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1044 , C09K2211/187 , G01N21/64 , G01N33/574 , G01N2800/52 , G02B21/0012
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公开(公告)号：EP1377220A1
公开(公告)日：2004-01-07
申请号：EP02728498.3
申请日：2002-03-15
CPC分类号： A61K49/0052 , A61B5/0071 , A61B5/0084 , A61B5/415 , A61B5/417 , A61B5/418 , A61B2090/3941 , A61K47/54 , A61K47/551 , A61K49/0032 , A61K49/0041 , A61K49/0043 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1044 , C09K2211/187 , G01N21/64 , G01N33/574 , G01N2800/52 , G02B21/0012
摘要： The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalamin. These fluorescent cobalamins can be used to as diagnostic and prognostic markers (a) to distinguish cancer cells and tissues from healthy cells and tissues, including identifying lymph nodes containing cancer cells, and (b) to determine if an individual will respond positively to chemotherapy using cobalamin-therapeutic bioconjugates.
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5.发明公开DEVICES AND METHODS FOR FLUORESCENT INSPECTION AND/OR REMOVAL OF MATERIAL IN A SAMPLE 审中-公开装置和FLURESZENZINSPEKTION和/或材料的去除在采样方法
公开(公告)号：EP2021802A2
公开(公告)日：2009-02-11
申请号：EP07783882.9
申请日：2007-05-17
IPC分类号： G01N33/574
CPC分类号： G01N33/574 , A61B5/0059 , A61B5/415 , A61B5/417 , A61B5/418 , A61B5/7415 , G01N21/645 , G01N33/582 , G01N33/82 , G01N2021/6484 , G01N2800/52
摘要： An apparatus is provided that includes a light emitting component, a light detecting component, a lock in amplifier, a frequency generator that is operatively linked to the lock in amplifier and the light emitting component, a speaker capable of emitting an audio signal wherein the output audio signal varies depending on the detected fluorescence in the sample, and a visible output of relative fluorescent intensity where the visible output varies depending on the detected fluorescence in the sample. The apparatus may also include a laser that is operatively coupled to the lock in amplifier through a control switch, and focusing lens or an additional type of filter such as an interference filter, a short pass filter, a notch filter, a long pass filter or an infrared filter. The apparatus may be used to identify and/or to remove fluorescent or non fluorescent material from a sample. Associated methods are also disclosed.
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6.发明公开
公开(公告)号：EP1370291A1
公开(公告)日：2003-12-17
申请号：EP02725145.3
申请日：2002-03-15
CPC分类号： A61K49/0032 , A61B1/00186 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B1/313 , A61B5/0071 , A61B5/0084 , A61B5/415 , A61B5/417 , A61B5/418 , A61B90/30 , A61B90/36 , A61B90/361 , A61B2090/3941 , A61K47/54 , A61K47/551 , A61K49/0041 , A61K49/0043 , A61K49/0052 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1044 , C09K2211/187 , G01N21/64 , G01N33/574 , G02B21/0012 , Y02B20/181
摘要： An apparatus that includes a surgical telescopic device having a distal end and a proximal end; a camera coupled to the proximal end of the surgical telescopic device; and a holographic notch filter interposed between the camera and the proximal end of the surgical telescopic device. The camera preferably is a charge-coupled-device camera ('CCD camera'). The apparatus may also include a focusing lens or an alternative type of filter such as a long-pass filter or an infrared filter. The surgical telescopic device may be used by illuminating the material with non-white light and detecting the emitted fluorescence, phosphorescence or luminescence.
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公开(公告)号：EP1226153A2
公开(公告)日：2002-07-31
申请号：EP00973834.5
申请日：2000-10-26
CPC分类号： A61K49/0052 , A61B5/415 , A61B5/417 , A61B5/418 , A61K47/551 , A61K49/0013 , A61K49/0015 , A61K49/0041 , A61K49/0043 , C07F15/065 , C09K11/06 , G01N33/52 , G01N33/574 , G01N2800/52
摘要： The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalamin. These fluorescent cobalamins can be used as diagnostic and prognostic markers (a) to distinguish cancer cells and tissues from healthy cells and tissues and (b) to determine if an individual will respond positively to chemotherapy using cobalamin-therapeutic bioconjugates.
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