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1.发明公开
公开(公告)号：EP1831181A2
公开(公告)日：2007-09-12
申请号：EP05853895.0
申请日：2005-12-13
发明人： MARTINEZ-BOTELLA, Gabriel , ARONOV, Alex , HALE, Michael, R. , MALTAIS, François , STRAUB, Judith , TANG, Qing
IPC分类号： C07D239/30 , A61K31/505
CPC分类号： C07D239/48
摘要： Described herein are compounds that are useful as protein kinase inhibitors of formula (I); or a pharmaceutically acceptable salt thereof, wherein Ring A, Z1, Z2, U, Q, R1, R2, and L are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
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公开(公告)号：EP1697375A2
公开(公告)日：2006-09-06
申请号：EP04812855.7
申请日：2004-12-02
发明人： STRAUB, Judith , HALE, Michael, R. , MALTAIS, François , MARTINEZ-BOTELLA, Gabriel , ARONOV, Alex , BEMIS, Guy, W.
IPC分类号： C07D487/08 , C07D401/04 , C07D239/48 , C07D405/04 , C07D403/04 , C07D251/18 , A61K31/506 , A61P35/00
CPC分类号： C07D239/48 , A61K31/506 , A61K45/06 , C07D251/18 , C07D401/04 , C07D403/04 , C07D405/04 , A61K2300/00
摘要： Described herein are compounds that are useful as protein kinase inhibitors of formula (I) or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, p, Q, R1, R2, R3, and R3 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.
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公开(公告)号：EP1546117A2
公开(公告)日：2005-06-29
申请号：EP03788433.5
申请日：2003-08-12
发明人： COCHRAN, John , GREEN, Jeremy , HALE, Michael, R. , LEDFORD, Brian , MALTAIS, François , NANTHAKUMAR, Suganthini
IPC分类号： C07D239/42 , C07D401/12 , C07D409/12 , C07D405/12 , C07D403/12 , C07D213/74 , A61K31/44 , A61K31/4418 , A61K31/505 , A61K31/506 , A61P19/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D213/74 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formulae (I) and (V) or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2 U, T, m, n, p, Q, Q', R1, R2, Rx, R3, and R6 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.
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公开(公告)号：EP1833820A1
公开(公告)日：2007-09-19
申请号：EP05854827.2
申请日：2005-12-20
发明人： ARONOV, Alex , HALE, Michael, R. , MALTAIS, François , MARTINEZ-BOTELLA, Gabriel , STRAUB, Judith , TANG, Qing
IPC分类号： C07D403/04 , A61K31/506 , A61P35/00
CPC分类号： C07D403/04
摘要： Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferate disorders such as cancer.
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公开(公告)号：EP1159278A2
公开(公告)日：2001-12-05
申请号：EP00913402.4
申请日：2000-02-09
发明人： HALE, Michael, R. , BAKER, Christopher, T. , STAMMERS, Timothy A. , SHERRILL, Ronald, G. , SPALTENSTEIN, Andrew , FURFINE, Eric, S. , MALTAIS, François , ANDREWS, Clarence, Webster, III , MILLER, John, F. , SAMANO, Vicente
IPC分类号： C07D493/04 , C07C311/29 , C07C311/42 , C07D317/62 , C07D307/20 , C07D319/06 , C07D407/12 , C07F9/6561 , A61K31/34 , A61K31/36 , A61K31/18 , A61K31/665
CPC分类号： C07D493/04 , C07C311/19 , C07C311/29 , C07C311/42 , C07C311/46 , C07C317/18 , C07C2601/08 , C07C2601/14 , C07D307/20 , C07D317/14 , C07D319/06 , C07D319/18 , C07D407/12 , C07F9/6561
摘要： The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
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公开(公告)号：EP3943489A1
公开(公告)日：2022-01-26
申请号：EP21190432.1
申请日：2005-05-13
发明人： MARTINEZ-BOTELLA, Gabriel , HALE, Michael, R. , MALTAIS, François , TANG, Qing , STRAUB, Judith
IPC分类号： C07D401/04 , A61K31/4439 , A61P9/00 , A61P25/00 , A61P37/00
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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7.发明公开
公开(公告)号：EP3608315A1
公开(公告)日：2020-02-12
申请号：EP19199330.2
申请日：2005-05-13
发明人： MARTINEZ-BOTELLA, Gabriel , HALE, Michael, R. , MALTAIS, François , TANG, Qing , STRAUB, Judith
IPC分类号： C07D401/04 , C07F9/58 , A61K31/4439 , A61P9/00 , A61P25/00 , A61P37/00
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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8.发明公开PYRROLE COMPOUNDS AS INHIBITORS OF ERK PROTEIN KINASES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS 审中-公开作为ERK蛋白激酶抑制剂的吡咯化合物和含有这些化合物的药物组合物
公开(公告)号：EP3305776A1
公开(公告)日：2018-04-11
申请号：EP17184079.6
申请日：2005-05-13
发明人： MARTINEZ-BOTELLA, Gabriel , HALE, Michael, R. , MALTAIS, François , TANG, Qing , STRAUB, Judith
IPC分类号： C07D401/04 , C07F9/58 , A61K31/4439 , A61P9/00 , A61P25/00 , A61P37/00
CPC分类号： C07F9/65583 , C07D401/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供了包含所述化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病，病症或障碍的方法。
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公开(公告)号：EP2651938A1
公开(公告)日：2013-10-23
申请号：EP11806096.1
申请日：2011-12-16
发明人： CHARIFSON, Paul, S. , CLARK, Michael P. , BANDARAGE, Upul K. , DENG, Hongbo , DAVIES, Ioana , DUFFY, John P. , FARMER, Luc J. , GAO, Huai , GU, Wenxin , KENNEDY, Joseph, M. , LEDEBOER, Mark, W. , LEDFORD, Brian , MALTAIS, François , PEROLA, Emanuele , WANNAMAKER, Marion W. , WANG, Tiansheng , SALITURO, Francesco, G.
IPC分类号： C07D471/04 , A61K31/4439 , A61K31/506 , A61K31/497 , A61K31/53
CPC分类号： C07D471/04
摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译： 抑制生物样品或患者中流感病毒的复制，减少生物样品或患者中流感病毒的量以及治疗患者中的流感的方法包括向所述生物样品或患者施用有效量的 由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。 结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。 药物组合物包含有效量的这样的化合物或其药学上可接受的盐和药学上可接受的载体，助剂或媒介物。
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10.发明公开PYRROLE COMPOUNDS AS INIBITORS OF ERK PROTEIN KINASE, SYNTHESIS THEREOF AND INTERMEDIATES THERETO 有权含有作为ERK蛋白激酶的抑制剂以及这些化合物的药物组合物的吡咯化合物
公开(公告)号：EP1753738A1
公开(公告)日：2007-02-21
申请号：EP05748073.3
申请日：2005-05-13
发明人： MARTINEZ-BOTELLA, Gabriel , HALE, Michael, R. , MALTAIS, François , TANG, Qing , STRAUB, Judith
IPC分类号： C07D401/04 , C07F9/58 , A61K31/4439 , A61P9/00 , A61P25/00 , A61P37/00
CPC分类号： C07F9/65583 , C07D401/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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