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1.发明公开PRODRUGS OF PYRROLYLPYRIMIDINE ERK PROTEIN KINASE INHIBITORS 有权前体药物THAN ERK蛋白激酶抑制剂署理PYRROLYLPYRIMIDINEN
公开(公告)号：EP1753744A1
公开(公告)日：2007-02-21
申请号：EP05756023.7
申请日：2005-05-13
发明人： MARTINEZ-BOTELLA, Gabriel , HALE, Michael, R. , MALTAIS, Francois , TANG, Qing , STRAUB, Judith
IPC分类号： C07D403/04 , A61K31/506 , A61P35/00
CPC分类号： C07D403/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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2.发明公开
公开(公告)号：EP1611125A1
公开(公告)日：2006-01-04
申请号：EP04707777.1
申请日：2004-02-03
发明人： ARONOV, Alex , HALE, Michael, R. , MALTAIS, Francois , TANG, Qing
IPC分类号： C07D403/04 , C07D401/14 , C07D487/04 , A61K31/4025 , A61P35/00
CPC分类号： C07D487/04 , C07D401/14 , C07D403/04
摘要： The present invention provides compounds that are inhibitors of protein kinase, particularly inhibitors of ERK2, GSK3, PKA, CDK2 protein kinases, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.
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公开(公告)号：EP1423380A1
公开(公告)日：2004-06-02
申请号：EP02791565.1
申请日：2002-08-02
IPC分类号： C07D401/04 , C07D405/14 , C07D401/14 , C07D403/14 , C07D413/14 , A61K31/4155 , A61K31/4439 , A61P35/00 , A61P29/00
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14
摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: (1) , where B, R?l, n, R3¿, Q, and R4 are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
摘要翻译： 本文描述的是可用作具有下式的蛋白激酶抑制剂的化合物：（1）其中B，R 1，n，R 3，Q和R 4在说明书中描述。 该化合物可用于治疗由蛋白激酶抑制剂缓解的哺乳动物的疾病状态，特别是诸如癌症，炎性疾病，再狭窄和心血管疾病的疾病。
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公开(公告)号：EP4043460A1
公开(公告)日：2022-08-17
申请号：EP22161962.0
申请日：2019-04-23
发明人： KULKARNI, Shashank , YU, Henry , CLARK, Michael , BEMIS, Guy , BOYD, Michael , CHANDUPATLA, Kishan , COLLIER, Philip , DENG, Hongbo , DONG, Huijun , DORSCH, Warren , HOOVER, Russell, R. , JOHNSON, Mac, Arthur, JR. , PENNEY, Marina , RONKIN, Steven , TAKEMOTO, Darin , TANG, Qing , WAAL, Nathan, D. , WANG, Tiansheng , LAUFFER, David J. , LI, Pan
IPC分类号： C07D413/14 , C07D403/04 , C07D409/14 , C07D413/04 , A61K31/553 , A61P35/00
摘要： The present invention provides compounds of Formula (I'), or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g. cancer).
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公开(公告)号：EP3985003A1
公开(公告)日：2022-04-20
申请号：EP21192836.1
申请日：2014-03-12
发明人： MAXWELL, John Patrick , CHARIFSON, Paul S. , TANG, Qing , RONKIN, Steven M. , JACKSON, Katrina Lee , PIERCE, Albert Charles , LAUFFER, David J. , LI, Pan , GIROUX, Simon , XU, Jinwang , MORRIS, Mark A. , COURT, John J. , COTTRELL, Kevin M. , DENG, Hongbo , WAAL, Nathan D. , GU, Wenxin
IPC分类号： C07D403/12 , C07D405/12 , C07D413/04 , C07D241/44 , C07D417/12 , C07D491/052 , A61K31/517 , A61P35/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：EP3969440A1
公开(公告)日：2022-03-23
申请号：EP20780387.5
申请日：2020-05-14
发明人： BANDARAGE, Upul Keerthi , BLIGH, Cavan McKeon , BOUCHER, Diane , BOYD, Michael John , BRODNEY, Michael Aaron , CLARK, Michael Philip , DAMAGNEZ, Veronique , FANNING, Lev Tyler Dewey , FIMOGNARI, Robert Francis , FLEMING, Gabrielle Simone , GAGNON, Kevin James , GARCIA BARRANTES, Pedro Manuel , GIACOMETTI, Robert Daniel , GIROUX, Simon , GREY JR., Ronald Lee , GUIDO, Samantha , HALL, Amy Beth , HOOD, Sarah Carol , HURLEY, Dennis James , JOHNSON, JR., Mac Arthur , JONES, Peter , KESAVAN, Sarathy , LAI, Mei-Hsiu , LIU, Siying , LOOKER, Adam , MAXWELL, Brad , MAXWELL, John Patrick , MEDEK, Ales , NUHANT, Philippe Marcel , OVERHOFF, Kirk Alan , RODAY, Setu , ROEPER, Stefanie , RONKIN, Steven M. , SAWANT, Rupa , SHI, Yi , SHRESTHA, Muna , SPOSATO, Marisa , STAVROPOULOS, Kathy , SWETT, Rebecca Jane , TANG, Qing , TAPLEY, Timothy Lewis , THOMSON, Stephen , XU, Jinwang , ZAKY, Mariam , COTTRELL, Kevin Michael
IPC分类号： C07D231/56 , C07D487/04 , C07D498/18 , C07D513/04 , A61P11/00 , A61P1/16 , A61K31/4162 , A61K31/429
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公开(公告)号：EP2435444A1
公开(公告)日：2012-04-04
申请号：EP10730618.5
申请日：2010-05-27
发明人： LI, Pan , WAAL, Nathan , RONKIN, Steven , TANG, Qing , LAUFFER, David
IPC分类号： C07D513/04 , A61K31/433 , A61P35/00
CPC分类号： C07D513/04
摘要： The present invention relates to compounds of formula (I), which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula (I) and methods of using the compositions in the treatment of proliferative disorders.
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公开(公告)号：EP1833820A1
公开(公告)日：2007-09-19
申请号：EP05854827.2
申请日：2005-12-20
发明人： ARONOV, Alex , HALE, Michael, R. , MALTAIS, François , MARTINEZ-BOTELLA, Gabriel , STRAUB, Judith , TANG, Qing
IPC分类号： C07D403/04 , A61K31/506 , A61P35/00
CPC分类号： C07D403/04
摘要： Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferate disorders such as cancer.
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公开(公告)号：EP4126863A1
公开(公告)日：2023-02-08
申请号：EP21721318.0
申请日：2021-04-02
发明人： GIROUX, Simon , NUHANT, Philippe Marcel , BANDARAGE, Upul Keerthi , GARCIA BARRANTES, Pedro Manuel , LIAO, Yusheng , GALE-DAY, Zachary , GU, Wenxin , KARNS, Alexander S. , ZHANG, Hu , ALLEN, Emily Elizabeth , XU, Jinwang , DENINNO, Michael Paul , TANG, Qing , BOUCHER, Diane Marie , FANNING, Lev T.D. , HALL, Amy B. , HURLEY, Dennis James , JOHNSON, JR., Mac Arthur , MAXWELL, John Patrick , SWETT, Rebecca Jane , TAPLEY, Timothy Lewis , THOMSON, Stephen A. , DAMAGNEZ, Veronique , COTTRELL, Kevin Michael
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公开(公告)号：EP3784666A1
公开(公告)日：2021-03-03
申请号：EP19726792.5
申请日：2019-04-23
发明人： YU, Henry , CLARK, Michael , BEMIS, Guy , BOYD, Michael , CHANDUPATLA, Kishan , COLLIER, Philip , DENG, Hongbo , DONG, Huijun , DORSCH, Warren , HOOVER, Russell, R. , JOHNSON, Mac, Arthur, JR. , KUKAMI, Shashank , PENNEY, Marina , RONKIN, Steven , TAKEMOTO, Darin , TANG, Qing , WAAL, Nathan, D. , WANG, Tiansheng , LAUFFER, David J. , LI, Pan
IPC分类号： C07D413/14 , C07D403/04 , C07D409/14 , C07D413/04 , A61K31/553 , A61P35/00
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