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1.发明授权AZAINDOLES USEFUL FOR THE TREATMENT OF (INTER ALIA) PROLIFERATIVE, CARDIAC, NEURODEGENERATIVE, AUTOIMMUNE OR INFLAMMATORY DISORDERS 有权FOR（包括）增殖性，心脏病，神经变性，自身免疫或炎性病症SUITABLE氮杂吲哚于治疗
公开(公告)号：EP1973911B1
公开(公告)日：2016-01-13
申请号：EP07718337.4
申请日：2007-01-17
发明人： FARMER, Luc , MARTINEZ-BOTELLA, Gabriel , PIERCE, Albert , SALITURO, Francesco , WANG, Jian , WANNAMAKER, Marion , WANG, Tiansheng
IPC分类号： C07D471/04 , A61K31/506 , A61K31/53 , A61P29/00 , C07D495/10 , A61K31/517 , A61P25/00 , A61P37/00
CPC分类号： A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D495/10 , C07D519/00 , C12N9/12 , C12Y207/10002
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2.发明公开PYRROLE COMPOUNDS AS INIBITORS OF ERK PROTEIN KINASE, SYNTHESIS THEREOF AND INTERMEDIATES THERETO 有权含有作为ERK蛋白激酶的抑制剂以及这些化合物的药物组合物的吡咯化合物
公开(公告)号：EP1753738A1
公开(公告)日：2007-02-21
申请号：EP05748073.3
申请日：2005-05-13
发明人： MARTINEZ-BOTELLA, Gabriel , HALE, Michael, R. , MALTAIS, François , TANG, Qing , STRAUB, Judith
IPC分类号： C07D401/04 , C07F9/58 , A61K31/4439 , A61P9/00 , A61P25/00 , A61P37/00
CPC分类号： C07F9/65583 , C07D401/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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3.发明公开
公开(公告)号：EP2144878A2
公开(公告)日：2010-01-20
申请号：EP08744172.1
申请日：2008-03-21
发明人： WANNAMAKER, Marion , SALITURO, Francesco , PIERCE, Albert , ARONOV, Alexander , MARTINEZ-BOTELLA, Gabriel , WANG, Jian , FARMER, Luc , LEDEBOER, Mark , WANG, Tiansheng , BETHIEL, Randy , LEDFORD, Brian , PORTER, Emilie
IPC分类号： C07D213/74
CPC分类号： C07D401/14 , C07D213/74 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：EP1833820A1
公开(公告)日：2007-09-19
申请号：EP05854827.2
申请日：2005-12-20
发明人： ARONOV, Alex , HALE, Michael, R. , MALTAIS, François , MARTINEZ-BOTELLA, Gabriel , STRAUB, Judith , TANG, Qing
IPC分类号： C07D403/04 , A61K31/506 , A61P35/00
CPC分类号： C07D403/04
摘要： Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferate disorders such as cancer.
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公开(公告)号：EP1931674B1
公开(公告)日：2012-12-12
申请号：EP06815526.6
申请日：2006-09-28
发明人： SALITURO, Francesco , FARMER, Luc , WANG, Tiansheng , WANG, Jian , BETHIEL, Randy , WANNAMAKER, Marion , MARTINEZ-BOTELLA, Gabriel , DUFFY, John , ARONOV, Alexander , LAUFFER, David , PIERCE, Albert
IPC分类号： C07D487/04 , C07D519/00 , A61K31/495 , A61P29/00 , A61P25/00 , A61P35/00 , A61P37/00
CPC分类号： C07D487/04
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6.发明公开
公开(公告)号：EP1831181A2
公开(公告)日：2007-09-12
申请号：EP05853895.0
申请日：2005-12-13
发明人： MARTINEZ-BOTELLA, Gabriel , ARONOV, Alex , HALE, Michael, R. , MALTAIS, François , STRAUB, Judith , TANG, Qing
IPC分类号： C07D239/30 , A61K31/505
CPC分类号： C07D239/48
摘要： Described herein are compounds that are useful as protein kinase inhibitors of formula (I); or a pharmaceutically acceptable salt thereof, wherein Ring A, Z1, Z2, U, Q, R1, R2, and L are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
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7.发明公开PRODRUGS OF PYRROLYLPYRIMIDINE ERK PROTEIN KINASE INHIBITORS 有权前体药物THAN ERK蛋白激酶抑制剂署理PYRROLYLPYRIMIDINEN
公开(公告)号：EP1753744A1
公开(公告)日：2007-02-21
申请号：EP05756023.7
申请日：2005-05-13
发明人： MARTINEZ-BOTELLA, Gabriel , HALE, Michael, R. , MALTAIS, Francois , TANG, Qing , STRAUB, Judith
IPC分类号： C07D403/04 , A61K31/506 , A61P35/00
CPC分类号： C07D403/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：EP1697375A2
公开(公告)日：2006-09-06
申请号：EP04812855.7
申请日：2004-12-02
发明人： STRAUB, Judith , HALE, Michael, R. , MALTAIS, François , MARTINEZ-BOTELLA, Gabriel , ARONOV, Alex , BEMIS, Guy, W.
IPC分类号： C07D487/08 , C07D401/04 , C07D239/48 , C07D405/04 , C07D403/04 , C07D251/18 , A61K31/506 , A61P35/00
CPC分类号： C07D239/48 , A61K31/506 , A61K45/06 , C07D251/18 , C07D401/04 , C07D403/04 , C07D405/04 , A61K2300/00
摘要： Described herein are compounds that are useful as protein kinase inhibitors of formula (I) or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, p, Q, R1, R2, R3, and R3 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.
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公开(公告)号：EP3943489A1
公开(公告)日：2022-01-26
申请号：EP21190432.1
申请日：2005-05-13
发明人： MARTINEZ-BOTELLA, Gabriel , HALE, Michael, R. , MALTAIS, François , TANG, Qing , STRAUB, Judith
IPC分类号： C07D401/04 , A61K31/4439 , A61P9/00 , A61P25/00 , A61P37/00
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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10.发明公开
公开(公告)号：EP3608315A1
公开(公告)日：2020-02-12
申请号：EP19199330.2
申请日：2005-05-13
发明人： MARTINEZ-BOTELLA, Gabriel , HALE, Michael, R. , MALTAIS, François , TANG, Qing , STRAUB, Judith
IPC分类号： C07D401/04 , C07F9/58 , A61K31/4439 , A61P9/00 , A61P25/00 , A61P37/00
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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