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    RADIO-LABELLED ANTIBODY FRAGMENTS FOR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER
    7.
    发明公开
    RADIO-LABELLED ANTIBODY FRAGMENTS FOR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER 审中-公开
    放射标记抗体片段用途在预防和/或治疗癌症

    公开(公告)号：EP3174559A1

    公开(公告)日：2017-06-07

    申请号：EP15744895.2

    申请日：2015-07-17

    申请人： Vrije Universiteit Brussel

    发明人： LAHOUTTE, Tony ,  DEVOOGDT, Nick ,  D'HUYVETTER, Matthias ,  DE VOS, Jens

    IPC分类号： A61K51/10 ,  A61P35/00

    CPC分类号： A61K51/1045 ,  A61K9/0019 ,  A61K51/1051 ,  A61K51/1069 ,  A61K51/1072 ,  A61K51/1078 ,  A61K51/1096 ,  C07K16/32 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

    摘要： The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (V
    HH ) or functional fragments thereof, wherein said V
    HH or functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor or cancer cell, e.g. HER2. The application further provides nucleic acids encoding such polypeptides; methods for preparing such polypeptides; host cells expressing or capable of expressing such polypeptides; compositions, and in particular to pharmaceutical compositions that comprise such polypeptides, nucleic acids and/or host cells. The application further provides such polypeptides, nucleic acids, host cells and/or compositions,for use in methods for the prevention and/or treatment of cancer.

    摘要翻译： 本申请提供了多肽，其包含或基本上由重链抗体（VHH）或其功能性片段的至少一个重链可变结构域的其worin所述V HH或其功能性片段特异性地结合到靶蛋白确实是存在于和/或特定的 用于固体肿瘤或癌症细胞，例如，HER2。 本申请还提供编码检查的多肽的核酸; 用于制备寻求多肽的方法; 宿主细胞中表达或能够表达寻求的多肽; 组合物，并且具体地涉及药物组合物确实包括搜索多肽，核酸和/或宿主细胞。 本申请还提供搜索多肽，核酸，宿主细胞和/或组合物，用于预防和/或治疗癌症的方法中使用。

    RADIO-LABELLED ANTIBODY FRAGMENTS FOR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER
    9.
    发明公开
    RADIO-LABELLED ANTIBODY FRAGMENTS FOR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER 审中-公开

    公开(公告)号：EP3718574A1

    公开(公告)日：2020-10-07

    申请号：EP20166462.0

    申请日：2015-07-17

    申请人： Vrije Universiteit Brussel

    发明人： LAHOUTTE, Tony ,  DEVOOGDT, Nick ,  D'HUYVETTER, Matthias ,  DE VOS, Jens

    IPC分类号： A61K51/10 ,  A61P35/00

    摘要： The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (V HH ) or functional fragments thereof, wherein said V HH or functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor or cancer cell, e.g. HER2. The application further provides nucleic acids encoding such polypeptides; methods for preparing such polypeptides; host cells expressing or capable of expressing such polypeptides; compositions, and in particular to pharmaceutical compositions that comprise such polypeptides, nucleic acids and/or host cells. The application further provides such polypeptides, nucleic acids, host cells and/or compositions, for use in methods for the prevention and/or treatment of cancer.