公开(公告)号：EP1337242A2

公开(公告)日：2003-08-27

申请号：EP01999202.3

申请日：2001-10-19

申请人： Valentis, Inc.

发明人： COLEMAN, Michael, E. ,  MACLAUGHLIN, Fiona ,  WANG, Jijun ,  THIESSE, Mary, L. ,  YOUNG, Stewart ,  NORDSTROM, Jeffrey, L.

IPC分类号： A61K9/14 ,  A61K48/00 ,  C12N15/63

CPC分类号： C12N15/87 ,  A61K38/1866 ,  A61K48/00 ,  A61K48/0008 ,  A61K48/0075 ,  C07K14/475

摘要： The present inventors have developed a novel approach for efficient delivery of angiogenic factors to the cardiac and peripheral vasculature that avoids problems with toxicity inherent to existing delivery technologies. Vectors carrying coding sequences for Del-1 or VEGF, or both, can be formulated with poloxamers or other polymers for delivery into ischemic tissue and delivered to the heart by retrograde venous perfusion.

公开(公告)号：EP1326969A2

公开(公告)日：2003-07-16

申请号：EP01977218.5

申请日：2001-09-25

申请人： Valentis Inc.

发明人： ABRUZZESE, Ronald, V. ,  MEHTA, Vidya ,  NORDSTROM, Jeffrey, L. ,  FEWELL, Jason G.

IPC分类号： C12N15/00

CPC分类号： C12N15/63 ,  A61K38/1816 ,  A61K48/00 ,  A61K48/0066 ,  C12N15/85 ,  C12N2830/002 ,  C12N2830/008 ,  C12N2830/42 ,  C12N2830/55 ,  C12N2830/702 ,  C12N2830/85 ,  C12N2830/90 ,  C12N2840/20 ,  C12N2840/44

摘要： Disclosed is a novel inducible expression system characterized by undetectable biological effect in the absence of an inducer, but which exhibits efficient inducibility in the presence of an inducer.

公开(公告)号：EP1030927A1

公开(公告)日：2000-08-30

申请号：EP98957671.5

申请日：1998-11-09

申请人： Valentis Inc.

发明人： LEDEBUR, Harry, C., Jr. ,  NORDSTROM, Jeffrey, L.

IPC分类号： C12N15/86 ,  A61K39/00

CPC分类号： A61K39/00 ,  A61K2039/51 ,  A61K2039/53 ,  C12N15/85 ,  C12N2830/42 ,  C12N2840/203 ,  C12N2840/44

摘要： Improved plasmids and methods for nucleic acid-based vaccines. The use of epitopes, small immunologically relevant protein sequences that are capable of inducing both cellular and humoral responses that result in a protective or therapeutic immune response against large and complex pathogens for incorporation into nucleic acid-based vaccines. The structures and characteristics of gene expression systems that are capable of expressing multiple epitopes. A method of genetic immunization comprising the step of presenting multiple epitopes to an organism in need of said immunization. A plasmid for expression of multiple epitopes comprising a nucleic acid sequence encoding multiple epitopes, wherein each of said epitopes is capable of creating an immune response. A multivalent expression system as shown in Figure 8 and selected from the group consisting of two plasmids, two genes, IRES, and alternative splicing and a method of making a plasmid producing the appropriate nucleic acid sequence.