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1.发明公开O-BENZYL NICOTINAMIDE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS 审中-公开O-BENZYL-NICOTINAMIDANALOGA ALS积极的ALLOSTERISCHE MGLUR5调制器
公开(公告)号：EP2482657A1
公开(公告)日：2012-08-08
申请号：EP10818037.3
申请日：2010-09-21
发明人： CONN, P., Jeffrey , LINDSLEY, Craig, W. , WEAVER, Charles, David , STAUFFER, Shaun, R. , WILLIAMS, Richard , MACDONALD, Gregor, James , BARTOLOME-NEBREDA, Jose, Manuel , ZHOU, Ya
CPC分类号： A61K31/44 , C07D213/80 , C07D213/85 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： In one aspect, the invention relates to 0-benzyl nicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions.
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2.发明公开
公开(公告)号：EP2378885A1
公开(公告)日：2011-10-26
申请号：EP09832601.0
申请日：2009-12-11
发明人： LINDSLEY, Craig, W. , CONN, P., Jeffrey , WEAVER, Charles, David , NISWENDER, Colleen, M. , WILLIAMS, Richard , JONES, Carrie, K. , SHEFFLER, Douglas, J.
IPC分类号： A01N55/02
CPC分类号： C07D209/52 , C07D403/12
摘要： In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GIyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GIyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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3.发明公开BENZISOXAZOLES AND AZABENZISOXAZOLES AS mgluR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 审中-公开苯并异恶唑AZABENZISOXAZOLE变构增强剂mGluR4和构成，并用于治疗神经机能障碍
公开(公告)号：EP2533642A1
公开(公告)日：2012-12-19
申请号：EP11742914.2
申请日：2011-02-11
发明人： CONN, P., Jeffrey , LINDSLEY, Craig, W. , HOPKINS, Corey, R. , WEAVER, Charles, David , NISWENDER, Colleen, M. , ENGERS, Darren, W.
CPC分类号： C07D498/04 , A61K31/42 , A61K31/423 , A61K31/4355 , A61K31/437 , A61K45/06 , C07D261/20 , C07D491/048
摘要： Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
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4.发明公开AMIDOBIPIPERIDINECARBOXYLATE M1 ALLOSTERIC AGONISTS, ANALOGS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND USING SAME 审中-公开变构AMIDOBIPIPERIDINCARBOXYLAT-M1激动剂类似物及其衍生物和方法的生产和使用
公开(公告)号：EP2398320A1
公开(公告)日：2011-12-28
申请号：EP10744395.4
申请日：2010-02-19
发明人： LINDSLEY, Craig, W. , CONN, Jeffrey, P. , WEAVER, Charles, David , NISWENDER, Colleen, M. , LEBOIS, Evan, P. , BRIDGES, Thomas, M.
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： C07D401/04 , C07D409/14
摘要： In one aspect, the invention relates to compounds having a general structure: Formula (I) which are useful as allosteric agonists of the M
1 muscarinic receptor; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurodegenerative diseases, including Alzheimer's Disease. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.-
5.发明公开HETEROCYCLIC SULFONE MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 审中-公开杂环磺酸盐MGLUR4变体增效剂，组合物和治疗神经功能障碍的方法
公开(公告)号：EP2568809A1
公开(公告)日：2013-03-20
申请号：EP11781297.4
申请日：2011-05-12
发明人： CONN, P., Jeffrey , LINDSLEY, Craig, W. , HOPKINS, Corey, R. , WEAVER, Charles, David , NISWENDER, Colleen, M. , GOGLIOTTI, Rocco, D. , CHEUNG, Yiu-Yin , SALOVICH, James, M. , ENGERS, Darren, W.
CPC分类号： A61K31/4439 , A61K45/06 , C07D401/12 , C07D413/12 , C07D417/12
摘要： Heterocyclic sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增效剂/正变构调节剂的杂环砜化合物; 和使用这些化合物的方法，例如，用于治疗与谷氨酸功能障碍相关的神经和精神疾病或其他疾病状态。
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6.发明公开SUBSTITUTED BENZAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 审中-公开取代BENZAMIDANALOGA负变构mGluR5调节剂和方法的生产和使用
公开(公告)号：EP2477630A1
公开(公告)日：2012-07-25
申请号：EP10817950.8
申请日：2010-09-17
发明人： CONN, P., Jeffrey , LINDSLEY, Craig, W. , EMMITTE, Kyle, A. , WEAVER, Charles, David , RODRIGUEZ, Alice, L. , FELTS, Andrew, S. , JONES, Carrie, K. , BATES, Brittney, S.
IPC分类号： A61K31/535
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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7.发明公开SUBSTITUTED HETEROARYLAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 有权取代HETEROARYLAMIDANALOGE负的mGluR5变构调节剂，和方法的生产和使用
公开(公告)号：EP2477629A1
公开(公告)日：2012-07-25
申请号：EP10817936.7
申请日：2010-09-17
发明人： CONN, P., Jeffrey , LINDSLEY, Craig, W. , EMMITTE, Kyle, A. , WEAVER, Charles, David , RODRIGUEZ, Alice, L. , FELTS, Andrew, S. , JONES, Carrie, K. , BATES, Brittney, S.
IPC分类号： A61K31/535
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention
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8.发明公开
公开(公告)号：EP2381941A1
公开(公告)日：2011-11-02
申请号：EP09837121.4
申请日：2009-12-29
发明人： LINDSLEY, Craig, W. , CONN, P., Jeffrey , WEAVER, Charles, David , NISWENDER, Colleen, M. , WILLIAMS, Richard , JONES, Carrie, K. , SHEFFLER, Douglas, J.
IPC分类号： A61K31/397 , A61K31/407
CPC分类号： C07D209/52 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12
摘要： In one aspect, the invention relates to compounds which are useful as as inhibitors of glycine type 1 transporter (GIyTl) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GIyTl) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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9.发明公开BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME 审中-公开积极的ALLOSTERISCHE MGLUR5-BENZAMIDMODULATOREN UND VERFAHREN ZU IHRER HERSTELLUNG UND VERWENDUNG
公开(公告)号：EP2162136A1
公开(公告)日：2010-03-17
申请号：EP08770045.6
申请日：2008-06-03
发明人： CONN, P., Jeffrey , LINDSLEY, Craig, W. , WEAVER, Charles, David , RODRIGUEZ, Alice, L. , NISWENDER, Colleen, M. , JONES, Carrie, K. , WILLIAMS, Richard
IPC分类号： A61K31/497
CPC分类号： C07D211/60 , A61K31/166 , A61K31/397 , A61K31/40 , A61K31/4035 , A61K31/4245 , A61K31/445 , A61K31/4453 , A61K31/451 , A61K31/4523 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4745 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07C233/65 , C07C233/66 , C07C233/69 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D205/04 , C07D207/09 , C07D209/46 , C07D209/48 , C07D211/18 , C07D211/22 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/52 , C07D211/58 , C07D213/74 , C07D217/06 , C07D217/24 , C07D271/06 , C07D295/13 , C07D295/14 , C07D295/192 , C07D295/30 , C07D401/04 , C07D401/10 , C07D401/12 , C07D409/04 , C07D413/12 , Y02A50/415
摘要： In one aspect, the invention relates to compounds, including benzamide derivatives and cyclic benzamide derivatives, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂的化合物，包括苯甲酰胺衍生物和环状苯甲酰胺衍生物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸功能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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10.发明授权SUBSTITUTED HETEROARYLAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 有权取代HETEROARYLAMIDANALOGE负的mGluR5变构调节剂，和方法的生产和使用
公开(公告)号：EP2477629B1
公开(公告)日：2016-08-03
申请号：EP10817936.7
申请日：2010-09-17
发明人： CONN, Jeffrey, P. , LINDSLEY, Craig, W. , EMMITTE, Kyle, A. , WEAVER, Charles, David , RODRIGUEZ, Alice, L. , FELTS, Andrew, S. , JONES, Carrie, K. , BATES, Brittney, S.
IPC分类号： A61K31/535 , A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14 , A61P25/00
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
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