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1.发明公开Compositions comprising pathogen-associated molecular patterns and antigens and their use to stimulate an immune response 审中-公开与病原体相关的分子模式和抗原以及它们的用途的组合物用于刺激免疫应答的
公开(公告)号：EP2374474A1
公开(公告)日：2011-10-12
申请号：EP10180988.7
申请日：2006-01-19
发明人： Powell, Thomas J , Nakaar, Valerian , Song, Langzhou , Huleatt, James W , McDonald, William , Hewitt, Duane D
CPC分类号： A61K39/12 , A61K38/162 , A61K38/164 , A61K39/0258 , A61K39/0275 , A61K2039/6068 , C07K14/005 , C07K14/245 , C07K14/255 , C07K2319/00 , C12N7/00 , C12N2770/24022 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Compositions comprise at least a portion of an antigen and at least a portion of a flagellin that lacks a hinge region. Compositions, fusion proteins and polypeptides comprise at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one viral protein. The viral protein of the compositions, fusion proteins and polypeptides of the invention are flaviviral proteins, including a West Nile flaviviral protein, a Dengue flaviviral protein, a Langat flaviviral protein, a Kunjin flaviviral protein, a Murray Valley encephalitis flaviviral protein, a Japanese encephalitis flaviviral protein, a Tick- borne encephalitis flaviviral protein, a Yellow fever flaviviral protein and a hepatitis C flaviviral protein. The compositions, fusion proteins and polypeptides are used to stimulate an immune response in a subject.
摘要翻译： 组合物包含至少一种抗原的一部分和至少一个鞭毛蛋白的一部分确实缺乏铰链区。 组合物，融合蛋白和多肽包括至少至少一种病原体相关分子模式至少一种病毒蛋白的一部分和至少一个部分上。 该发明的组合物，融合蛋白和多肽的病毒蛋白是黄病毒蛋白，包括西尼罗河黄病毒蛋白，登革黄病毒蛋白，兰加特黄病毒蛋白，库京黄病毒蛋白，墨累谷脑炎黄病毒蛋白，日本脑炎 黄病毒蛋白，蜱传脑炎黄病毒蛋白，黄热病黄病毒蛋白和丙型肝炎黄病毒蛋白。 组合物，融合蛋白和多肽用于刺激受试者中的免疫应答。
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2.发明公开Compositions that include hemagglutinin, methods of making and methods of use thereof 有权含HA的组合物，涉及它们的用途及其制备方法和方法
公开(公告)号：EP2476432A1
公开(公告)日：2012-07-18
申请号：EP11166122.9
申请日：2007-03-06
发明人： Song, Langzhou , Nakaar, Valerian , Price, Albert E. , Tussey, Lynda G. , Huleatt, James W. , Powell, Thomas J. , Evans, Robert K.
IPC分类号： A61K39/02 , A61K39/145 , A61P31/00
CPC分类号： A61K39/145 , A61K39/00 , A61K39/02 , A61K39/0258 , A61K39/12 , A61K39/385 , A61K2039/543 , A61K2039/575 , A61K2039/6018 , A61K2039/6037 , A61K2039/6068 , A61K2039/6075 , C07K14/005 , C07K14/11 , C07K14/195 , C07K14/255 , C07K2319/00 , C12N7/00 , C12N15/62 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271 , C12N2760/16322 , C12N2760/16334 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/41 , Y02A50/412 , Y02A50/472 , Y02A50/474
摘要： Methods of making and compositions that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the portion includes at least a portion of a globular head, includes at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and lacks a membrane fusion domain, a transmembrane domain and a cytoplasmic domain. Compositions comprise a flagellin component or a Toll-like Receptor agonist component that is at least a portion of a flagellin or a Toll-like Receptor agonist, wherein the flagellin component or Toll-like Receptor agonist component includes at least one cysteine residue and whereby the flagellin component or Toll-like Receptor agonist component activates a Toll-like Receptor 5 or Toll-like Receptor. Compositions comprise a flagellin component that is at least a portion of a flagellin, wherein at least one lysine of the flagellin component has been substituted with at least one arginine, serine and histidine, whereby the flagellin component activates Toll-like Receptor 5. Compositions can further include an antigen, such as an influenza antigen, a flavivirus antigen, a pathogen-related antigen, a bacterial capsular antigen and a carrier protein. The compositions are used to stimulate an immune response and a protective immune response in a subject.
摘要翻译： 制备和组合物的方法做了刺激受试者中的保护性免疫应答包括来自天然存在的病毒血凝素蛋白质的一部分，worin所述部分包括至少一个球状头部的一部分，包括至少至少一个次要的一部分 结构也使球状头部基本上保留其三级结构和缺少膜融合结构域，跨膜结构域和胞质结构域。 组合物包含鞭毛蛋白组分或Toll样受体激动剂组分所做的是至少一个鞭毛蛋白或Toll样受体激动剂的一部分，worin鞭毛蛋白组分或Toll样受体激动剂组分包括至少一个半胱氨酸残基，并且其中所述 鞭毛蛋白组分或Toll样受体激动剂组分激活Toll样受体5或Toll样受体。 组合物包含鞭毛蛋白成分确实被至少一个鞭毛蛋白的部分，所述鞭毛蛋白组分worin至少一个赖氨酸已经substituiertem与至少一种精氨酸，丝氨酸和组氨酸，由此鞭毛部件的激活Toll样受体5的组合物可以 进一步包括抗原检查，以流感病毒抗原，黄病毒抗原，病原体相关抗原，细菌荚膜抗原和载体蛋白。 所述组合物用于刺激免疫反应和在受试者中产生保护性免疫应答。
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3.发明授权Compositions that include hemagglutinin, methods of making and methods of use thereof 有权含HA的组合物，涉及它们的用途及其制备方法和方法
公开(公告)号：EP2476432B1
公开(公告)日：2015-08-19
申请号：EP11166122.9
申请日：2007-03-06
发明人： Song, Langzhou , Nakaar, Valerian , Price, Albert E. , Tussey, Lynda G. , Huleatt, James W. , Powell, Thomas J. , Evans, Robert K.
IPC分类号： A61K39/02 , A61K39/145 , A61P31/00
CPC分类号： A61K39/145 , A61K39/00 , A61K39/02 , A61K39/0258 , A61K39/12 , A61K39/385 , A61K2039/543 , A61K2039/575 , A61K2039/6018 , A61K2039/6037 , A61K2039/6068 , A61K2039/6075 , C07K14/005 , C07K14/11 , C07K14/195 , C07K14/255 , C07K2319/00 , C12N7/00 , C12N15/62 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271 , C12N2760/16322 , C12N2760/16334 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/41 , Y02A50/412 , Y02A50/472 , Y02A50/474
摘要： Methods of making and compositions that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the portion includes at least a portion of a globular head, includes at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and lacks a membrane fusion domain, a transmembrane domain and a cytoplasmic domain. Compositions comprise a flagellin component or a Toll-like Receptor agonist component that is at least a portion of a flagellin or a Toll-like Receptor agonist, wherein the flagellin component or Toll-like Receptor agonist component includes at least one cysteine residue and whereby the flagellin component or Toll-like Receptor agonist component activates a Toll-like Receptor 5 or Toll-like Receptor. Compositions comprise a flagellin component that is at least a portion of a flagellin, wherein at least one lysine of the flagellin component has been substituted with at least one arginine, serine and histidine, whereby the flagellin component activates Toll-like Receptor 5. Compositions can further include an antigen, such as an influenza antigen, a flavivirus antigen, a pathogen-related antigen, a bacterial capsular antigen and a carrier protein. The compositions are used to stimulate an immune response and a protective immune response in a subject.
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4.发明公开Novel polypeptide ligands for toll-like receptor 2 (TLR2) 审中-公开Neol Polypeptid-LigendenfürToll-like-Rezeptor 2（TLR2）
公开(公告)号：EP2042186A1
公开(公告)日：2009-04-01
申请号：EP09000056.3
申请日：2006-01-30
发明人： Nakaar, Valerian , Huang, Yan , Powel, Thomas, J.
CPC分类号： A61K39/385 , A61K39/0208 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/55516 , A61K2039/57 , C07K5/1013 , C07K5/1019 , C07K7/06 , C07K14/195 , C07K14/705 , C12N2795/10243 , Y02A50/386 , Y02A50/394
摘要： The present invention provides novel polypeptide ligands for Toll-like Receptor 2 (TLR2). Preferably, the novel polypeptide ligands modulate TLR2 signaling and thereby regulate the Innate Immune Response. The invention also provides vaccines comprising the novel polypeptide TLR2 ligands and an antigen. The invention further provides methods of modulating TLR2 signaling using the polypeptide ligands or vaccines of the invention.
摘要翻译： 本发明提供了Toll样受体2（TLR2）的新型多肽配体。 优选地，新型多肽配体调节TLR2信号传导，从而调节先天免疫应答。 本发明还提供了包含新型多肽TLR2配体和抗原的疫苗。 本发明还提供了使用本发明的多肽配体或疫苗调节TLR2信号传导的方法。
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