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公开(公告)号：EP2963011B1
公开(公告)日：2018-05-09
申请号：EP15001958.6
申请日：2006-11-21
发明人： Bieniarz, Christopher , Ashworth-Sharpe, Julia , Kernag, Casey A. , Kosmeder, Jerome W. , Lefever, Mark
IPC分类号： C07C319/02 , C07C327/28 , G01N33/532 , A61K47/68 , C07C323/60 , C12N9/16 , C12N9/96
CPC分类号： G01N33/581 , A61K39/44 , A61K47/6801 , A61K47/6803 , A61K47/6815 , C07C319/02 , C07C323/22 , C07C323/60 , C07C327/28 , C07K16/00 , C12N9/16 , C12N9/96 , C12Y301/03001 , G01N33/532 , G01N33/535 , C07C323/12
摘要： The present invention relates to conjugates comprising an antibody, a detectable label, and a plurality of hydrazide thiol linkers. The present invention further relates to methods for detecting a target molecule in a cell or tissue sample, said methods using said conjugates.
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公开(公告)号：EP2963011A1
公开(公告)日：2016-01-06
申请号：EP15001958.6
申请日：2006-11-21
发明人： Bieniarz, Christopher , Ashworth-Sharpe, Julia , Kernag, Casey A. , Kosmeder, Jerome W. , Lefever, Mark
IPC分类号： C07C319/02 , C07C327/28 , G01N33/532 , A61K47/48
CPC分类号： G01N33/581 , A61K39/44 , A61K47/6801 , A61K47/6803 , A61K47/6815 , C07C319/02 , C07C323/22 , C07C323/60 , C07C327/28 , C07K16/00 , C12N9/16 , C12N9/96 , C12Y301/03001 , G01N33/532 , G01N33/535 , C07C323/12
摘要： The present invention relates to conjugates comprising an antibody, a detectable label, and a plurality of hydrazide thiol linkers. The present invention further relates to methods for detecting a target molecule in a cell or tissue sample, said methods using said conjugates.
摘要翻译： 本发明涉及包含抗体，可检测标记和多个酰肼硫醇接头的缀合物。 本发明还涉及用于检测细胞或组织样品中的靶分子的方法，所述方法使用所述缀合物。
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3.发明公开
公开(公告)号：EP4206645A1
公开(公告)日：2023-07-05
申请号：EP23151184.1
申请日：2016-05-13
摘要： Methods and compositions for removing precipitates or reducing the formation of precipitates generated in hematoxylin solutions. The methods and compositions feature cleaning solutions that feature chemical compounds that initiate processes including but not limited to acidification of the waste solution, chelation of metal ions in the waste solution, reduction reactions, oxidation reactions, and metal salt addition reactions.
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4.发明公开ENZYMES CONJUGATED TO ANTIBODIES VIA A PEG HETEROBIFUCTIONAL LINKER 审中-公开ENZYME KONJUGIERT AN ANKKERRPERÜBEREINEN PEG HETEROBIFUKTIONSLINKER
公开(公告)号：EP3144675A1
公开(公告)日：2017-03-22
申请号：EP16002184.6
申请日：2006-04-27
发明人： Bieniarz, Christopher , Wong, Jennifer , Lefever, Mark , Kosmeder, Jerome W. , Ashworth-Sharpe, Julia , Kernag, Casey A.
IPC分类号： G01N33/535 , G01N33/533
CPC分类号： G01N33/535 , A61K47/65 , A61K47/6815 , C07K16/42 , C07K16/44 , C07K2317/76 , C12N9/0065 , C12N9/16 , C12N9/96
摘要： The present invention relates to antibody-signal generating moiety conjugates, wherein the antibody is covalently linked to the signal generating moiety through a heterobifunctional polyethylene glycol (PEG) linker.
摘要翻译： 本发明涉及抗体信号产生部分缀合物，其中抗体通过异双功能聚乙二醇（PEG）接头与信号产生部分共价连接。
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5.发明授权
公开(公告)号：EP1636586B1
公开(公告)日：2009-07-22
申请号：EP04756257.4
申请日：2004-06-24
发明人： Bieniarz, Christopher , Kernag, Casey A. , Kosmeder, Jerome W. , Rodgers, Paula M. , Wong, Jennifer
CPC分类号： G01N33/581 , C07F9/093 , C07F9/65517 , C07F9/65522 , C07H15/20 , C07H15/24 , C07H15/26
摘要： The invention is directed to novel compositions of matter and methods of detecting in situ an immunohistochemical epitope or nucleic acid sequence of interest in a biological sample comprising binding an enzyme-labeled conjugate molecule to the epitope or sequence of interest in the presence of a redox-inactive reductive species and a soluble metal ion, thereby facilitating the reduction of the metal ion to a metal atom at or about the point where the enzyme is anchored. Novel phosphate derivatives of reducing agents are described that when exposed to a phosphatase are activated to their reducing form, thereby reducing metal ions to insoluble metal.
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6.发明公开
公开(公告)号：EP1636586A2
公开(公告)日：2006-03-22
申请号：EP04756257.4
申请日：2004-06-24
发明人： Bieniarz, Christopher , Kernag, Casey A. , Kosmeder, Jerome W. , Rodgers, Paula M. , Wong, Jennifer
CPC分类号： G01N33/581 , C07F9/093 , C07F9/65517 , C07F9/65522 , C07H15/20 , C07H15/24 , C07H15/26
摘要： The invention is directed to novel compositions of matter and methods of detecting in situ an immunohistochemical epitope or nucleic acid sequence of interest in a biological sample comprising binding an enzyme-labeled conjugate molecule to the epitope or sequence of interest in the presence of a redox-inactive reductive species and a soluble metal ion, thereby facilitating the reduction of the metal ion to a metal atom at or about the point where the enzyme is anchored. Novel phosphate derivatives of reducing agents are described that when exposed to a phosphatase are activated to their reducing form, thereby reducing metal ions to insoluble metal.
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