利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

29 条记录 (耗时 0.03 秒)

    PYRAZOLOPYRAZINE KINASE INHIBITORS
    6.
    发明公开
    PYRAZOLOPYRAZINE KINASE INHIBITORS 审中-公开
    吡唑并吡嗪激酶抑制剂

    公开(公告)号：EP2550272A1

    公开(公告)日：2013-01-30

    申请号：EP11703959.4

    申请日：2011-01-26

    申请人： Vertex Pharmaceuticals Incorporated

    发明人： JIMENEZ, Juan-Miguel ,  SETTIMO, Luca ,  FRAYSSE, Damien ,  BRENCHLEY, Guy ,  DAVIS, John, Christopher ,  MILLER, Andrew, W.

    IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61P37/00 ,  A61P29/00

    CPC分类号： C07D487/04

    摘要： The present invention relates to pyrazolopyrazine compounds useful as inhibitors of protein kinase specially PKC theta. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

    摘要翻译： 吡唑并吡嗪化合物本发明涉及用作蛋白激酶（特别是PKCθ）抑制剂的吡唑并吡嗪化合物。 本发明还提供了包含所述化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病，病症或障碍的方法。 本发明还提供了制备本发明化合物的方法。

    THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES
    9.
    发明公开
    THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES 审中-公开
    噻吩甲酰胺用作蛋白激酶抑制剂

    公开(公告)号：EP2027116A2

    公开(公告)日：2009-02-25

    申请号：EP07795219.0

    申请日：2007-05-23

    申请人： VERTEX PHARMACEUTICALS INCORPORATED

    发明人： BRENCHLEY, Guy ,  CHARRIER, Jean-Damien ,  DURRANT, Steven ,  KNEGTEL, Ronald ,  RAMAYA, Sharn

    IPC分类号： C07D409/04

    CPC分类号： C07D409/04

    摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

    摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供了包含所述化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病，病症或障碍的方法。 本发明还提供了制备本发明化合物的方法。