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公开(公告)号：EP4347583A1
公开(公告)日：2024-04-10
申请号：EP22736097.1
申请日：2022-06-03
发明人： BECK, Elizabeth Mary , PULLIN, Robert , ETXEBARRIA JARDI, Gorka , STAMOS, Dean , SCHMIDT, Yvonne , PONTILLO, Joseph , THOMSON, Stephen Andrew , SHAW, David Matthew , AHMAD, Nadia M. , CARVALHO MEIRELES, Lidio Marx , SKERRATT, Sarah , HADIDA RUAH, Sara S. , NEUBERT, Timothy Donald , HURLEY, Dennis James , KINTZER, Alexander , DURRANT, Steven John , WRAY, Christopher , VIRANI, Anisa Nizarali , NORTH, Kiri , JACQUES, Reece , GEDDIS, Stephen Michael , GALAN, Bhairavi , KNEGTEL, Ronald Marcellus , CHUDYK, Ewa Iwona , PINDER, Joanne Louise , SOUSA, Bruno Artur , FRAYSSE, Damien , MUI, James Jun Bon , AUSTIN, James Robert , STORCK, Pierre-Henri
IPC分类号： C07D405/12 , C07D405/14 , C07D493/10 , C07D413/14 , C07D471/04 , C07D471/08 , C07D487/10 , C07D491/048 , C07D491/08 , C07D491/10 , C07D498/04 , C07D498/08 , A61K31/443 , A61K31/497 , A61P29/00
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公开(公告)号：EP2318408B1
公开(公告)日：2016-02-17
申请号：EP09790736.4
申请日：2009-07-22
发明人： JIMENEZ, Juan-Miguel , STUDLEY, John , DAVIS, Chris , SETTIMO, Luca , COLLIER, Philip , FRAYSSE, Damien , KNEGTEL, Ronald , BOYALL, Dean , BRENCHLEY, Guy , MILLER, Andrew , TWIN, Heather , YOUNG, Stephen
IPC分类号： C07D471/04 , A61P29/00 , A61P35/00 , A61P37/00 , A61K31/437
CPC分类号： C07D471/04
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3.发明公开
公开(公告)号：EP3486245A1
公开(公告)日：2019-05-22
申请号：EP18212042.8
申请日：2013-12-06
发明人： AHMAD, Nadia , BOYALL, Dean , CHARRIER, Jean-Damien , DAVIS, Chris , DAVIS, Rebecca , DURRANT, Steven , ETXEBARRIA I JARDI, Gorka , FRAYSSE, Damien , JIMENEZ, Juan-Miguel , KAY, David , KNEGTEL, Ronald , MIDDELTON, Donald , ODONNELL, Michael , PANESAR, Maninder , PIERARD, Francoise , PINDER, Joanne , SHAW, David , STORCK, Pierre-Henri , STUDLEY, John , TWIN, Heather
IPC分类号： C07D487/04 , A61K31/495 , A61P35/00 , C07D453/02 , C07D471/08 , C07D491/107 , C07D498/04 , C07D498/10
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula I:
or a pharmaceutically acceptable salt, wherein the variables are as devined herein.
Moreover, The compounds of this invention have formula I-A:
or a pharmaceutically acceptable salt, wherein the variables are as defined herein.-
公开(公告)号：EP2582702A1
公开(公告)日：2013-04-24
申请号：EP11703960.2
申请日：2011-01-26
发明人： JIMENEZ, Juan-Miguel , SETTIMO, Luca , FRAYSSE, Damien , BRENCHLEY, Guy , DAVIS, John, Christopher , MILLER, Andrew, W.
IPC分类号： C07D487/04 , A61K31/519 , A61P31/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供了包含所述化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病，病症或障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：EP2313372B1
公开(公告)日：2013-04-10
申请号：EP09791213.3
申请日：2009-08-06
发明人： MALTAIS, Francois , BEMIS, Guy, W. , WANG, Tiansheng , JIMENEZ, Juan-Miguel , SETTIMO, Luca , BOYALL, Dean , FRAYSSE, Damien , YOUNG, Stephen , DAVIS, Christopher John
IPC分类号： C07D213/73 , C07D213/74 , C07D401/04 , C07D407/04 , C07D407/12 , C07D417/14 , A61K31/44 , A61K31/4427 , A61P37/00
CPC分类号： C07D417/14 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/10 , C07D401/14 , C07D407/04 , C07D407/12
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公开(公告)号：EP2550272A1
公开(公告)日：2013-01-30
申请号：EP11703959.4
申请日：2011-01-26
发明人： JIMENEZ, Juan-Miguel , SETTIMO, Luca , FRAYSSE, Damien , BRENCHLEY, Guy , DAVIS, John, Christopher , MILLER, Andrew, W.
IPC分类号： C07D487/04 , A61K31/4985 , A61P37/00 , A61P29/00
CPC分类号： C07D487/04
摘要： The present invention relates to pyrazolopyrazine compounds useful as inhibitors of protein kinase specially PKC theta. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 吡唑并吡嗪化合物本发明涉及用作蛋白激酶（特别是PKCθ）抑制剂的吡唑并吡嗪化合物。 本发明还提供了包含所述化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病，病症或障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：EP2328896A1
公开(公告)日：2011-06-08
申请号：EP09790733.1
申请日：2009-07-22
IPC分类号： C07D471/04 , A61K31/437 , A61P35/02 , A61P37/00
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of the formula (I), which are useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：EP1951715A2
公开(公告)日：2008-08-06
申请号：EP06827465.3
申请日：2006-11-03
IPC分类号： C07D403/14 , A61K31/4155 , C07D239/02
CPC分类号： C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds useful as inhibitors of Aurora protein kinases . The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders . The invention also provides processes for preparing compounds of the invention.
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公开(公告)号：EP3077393A1
公开(公告)日：2016-10-12
申请号：EP13811718.9
申请日：2013-12-06
发明人： BOYALL, Dean , CHARRIER, Jean-Damien , DAVIS, Chris , DURRANT, Steven , ETXEBARRIA I JARDI, Gorka , FRAYSSE, Damien , KAY, David , KNEGTEL, Ronald , PINDER, Joanne
IPC分类号： C07D471/04 , C07D487/04 , A61P35/00 , A61K31/437
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention are represented by formula (I-A) and formula (I-B); or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
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公开(公告)号：EP1948193B1
公开(公告)日：2015-01-07
申请号：EP06836890.1
申请日：2006-11-03
发明人： BINCH, Hayley , MORTIMORE, Michael , FRAYSSE, Damien , DAVIS, Chris , O'DONNELL, Michael , EVERITT, Simon , ROBINSON, Daniel , PINDER, Joanne , MILLER, Andrew
IPC分类号： C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/505
CPC分类号： C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
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