专利检索 ap:("Vertex Pharmaceuticals Incorporated") AND inv:"COTTRELL, Kevin" 第 1 页

1.

发明公开
INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE 审中-公开
标题翻译：磷脂酰肌醇3-激酶抑制剂

公开(公告)号：EP2283013A1

公开(公告)日：2011-02-16

申请号：EP09733572.3

申请日：2009-04-14

申请人： Vertex Pharmaceuticals Incorporated

发明人： WANG, Tiansheng , ARONOV, Alexander , CORNEBISE, Mark , MALTAIS, Francois , LEDOBOER, Mark , LE TIRAN, Arnaud , MARONE, Valerie , MESSERSMITH, David , COTTRELL, Kevin , COME, Jon, H. , BOTELA, Gabriel, Martinez

IPC分类号： C07D417/04 , C07D513/04 , A61K31/428 , A61K31/4365 , A61P37/00

CPC分类号： C07D513/04 , C07D417/04

摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K ggr;. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

摘要翻译： 本发明涉及用作PI3K抑制剂的化合物，特别是PI3K ggr。的抑制剂。本发明还提供了包含所述化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病，病症或障碍的方法。

2.

发明公开
TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS 审中-公开
标题翻译： TRICYCLISCHE PYRAZOLOPYRIDINE ALS KINASEINHIBITOREN

公开(公告)号：EP2401273A1

公开(公告)日：2012-01-04

申请号：EP10706860.3

申请日：2010-02-25

申请人： Vertex Pharmaceuticals Incorporated

发明人： ARONOV, Alex , COME, Jon , COTTRELL, Kevin , GREY, Ronald , LE TIRAN, Amaud , MARONE, Valerie , MARTINEZ-BOTELLA, Gabriel , MESSERSMITH, David , HUCK, Emilie, Porter

IPC分类号： C07D417/04 , C07D513/04 , C07D417/14 , A61K31/4965 , A61K31/4427 , A61K31/506 , A61K31/501 , A61P29/00 , A61P37/00

CPC分类号： C07D417/14 , C07D417/04 , C07D513/04

摘要： The present invention relates to compounds useful as inhibitors of P13K, particularly of P13Kgamma. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of several diseases, such as cancer and autoimmune diseases.

3.

发明公开
TETRAHYDROTHIAZOLOPYRIDINE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE 审中-公开
标题翻译： TETRAHYDROTHIAZOLOPYRIDINE AS磷脂酰肌醇3激酶抑制剂

公开(公告)号：EP2398810A1

公开(公告)日：2011-12-28

申请号：EP10706423.0

申请日：2010-02-16

申请人： Vertex Pharmaceuticals Incorporated

发明人： ARONOV, Alex , BANDARAGE, Upul, Keerthi , COTTRELL, Kevin , DAVIES, Robert , KRUEGER, Elaine , LEDEBOER, Mark , LEDFORD, Brian , LE TIRAN, Arnaud , LIAO, Yusheng , MESSERSMITH, David , WANG, Tiansheng , XU, Jinwang

IPC分类号： C07D513/04 , A61K31/4365 , A61P25/00

CPC分类号： C07D513/04

摘要： The present invention relates to compounds (I) useful as inhibitors of PBK, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.