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公开(公告)号：EP3250562A1
公开(公告)日：2017-12-06
申请号：EP16744240.9
申请日：2016-01-29
发明人： DECRESCENZO, Gary , WELSCH, Dean , VLAHOVA, Petinka I. , BOERRIGTER, Stephan X.M. , ARONOV, Alexander , KESHAVARZ-SHOKRI, Ali , SCANGAS, Alexander N. , STAVROPOULOS, Kathy , LITTLER, Benjamin , KADIYALA, Irina Nikolaevna , ALARGOVA, Rossitza Gueorguieva
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , A61K31/4439 , A61K45/06 , A61P35/00
摘要： The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.
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公开(公告)号：EP1963329B1
公开(公告)日：2013-01-23
申请号：EP06838683.8
申请日：2006-11-30
发明人： LAUFFER, David , ARONOV, Alexander , LI, Pan , DEININGER, David , MCGINTY, Kira , STAMOS, Dean , COME, Jon , STEWART, Michelle
IPC分类号： C07D487/04 , C07D513/04 , C07D519/00 , A61P35/00 , A61K31/433
CPC分类号： C07D498/04 , C07D487/04 , C07D513/04
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公开(公告)号：EP1963329A2
公开(公告)日：2008-09-03
申请号：EP06838683.8
申请日：2006-11-30
发明人： LAUFFER, David , ARONOV, Alexander , LI, Pan , DEININGER, David , MCGINTY, Kira , STAMOS, Dean , COME, Jon , STEWART, Michelle
IPC分类号： C07D487/04 , C07D513/04 , C07D519/00 , A61P35/00 , A61K31/433
CPC分类号： C07D498/04 , C07D487/04 , C07D513/04
摘要： The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
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公开(公告)号：EP1506189A1
公开(公告)日：2005-02-16
申请号：EP03736503.8
申请日：2003-04-25
IPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D487/04 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , C07D207/333 , C07D207/337 , C07D403/04 , C07D405/14 , C07D471/04
摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein A1, A2, TmR1, X, R2, R3, R9, R12, and R13 Are as described in the specification. The compounds are especially useful as inhibitors of ERK2, Aurora2, GSK3, CDK2, AKT3, and ROCK protein kinases and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, neurodegenerative disorders, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.
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5.发明公开
公开(公告)号：EP2144878A2
公开(公告)日：2010-01-20
申请号：EP08744172.1
申请日：2008-03-21
发明人： WANNAMAKER, Marion , SALITURO, Francesco , PIERCE, Albert , ARONOV, Alexander , MARTINEZ-BOTELLA, Gabriel , WANG, Jian , FARMER, Luc , LEDEBOER, Mark , WANG, Tiansheng , BETHIEL, Randy , LEDFORD, Brian , PORTER, Emilie
IPC分类号： C07D213/74
CPC分类号： C07D401/14 , C07D213/74 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：EP1931674B1
公开(公告)日：2012-12-12
申请号：EP06815526.6
申请日：2006-09-28
发明人： SALITURO, Francesco , FARMER, Luc , WANG, Tiansheng , WANG, Jian , BETHIEL, Randy , WANNAMAKER, Marion , MARTINEZ-BOTELLA, Gabriel , DUFFY, John , ARONOV, Alexander , LAUFFER, David , PIERCE, Albert
IPC分类号： C07D487/04 , C07D519/00 , A61K31/495 , A61P29/00 , A61P25/00 , A61P35/00 , A61P37/00
CPC分类号： C07D487/04
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公开(公告)号：EP2283013A1
公开(公告)日：2011-02-16
申请号：EP09733572.3
申请日：2009-04-14
发明人： WANG, Tiansheng , ARONOV, Alexander , CORNEBISE, Mark , MALTAIS, Francois , LEDOBOER, Mark , LE TIRAN, Arnaud , MARONE, Valerie , MESSERSMITH, David , COTTRELL, Kevin , COME, Jon, H. , BOTELA, Gabriel, Martinez
IPC分类号： C07D417/04 , C07D513/04 , A61K31/428 , A61K31/4365 , A61P37/00
CPC分类号： C07D513/04 , C07D417/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K ggr;. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及用作PI3K抑制剂的化合物，特别是PI3K ggr。的抑制剂。 本发明还提供了包含所述化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病，病症或障碍的方法。
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8.发明授权C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 有权c-Met蛋白激酶抑制剂来治疗增生性疾病
公开(公告)号：EP2004625B1
公开(公告)日：2009-12-30
申请号：EP07753626.6
申请日：2007-03-21
发明人： LAUFFER, David, J. , DAVIES, Robert, J. , STAMOS, Dean , ARONOV, Alexander , DEININGER, David, D. , GREY, Ronald, Jr. , XU, Jinwang , LI, Pan , LEDFORD, Brian , FARMER, Luc , BETHIEL, Randy, Scott , JACOBS, Dylan , MCGINTY, Kira
IPC分类号： C07D401/04 , C07D403/04 , C07D417/04 , C07D471/04 , A61K31/4439 , A61K31/497 , A61K35/00 , A61P35/04
CPC分类号： C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D451/02 , C07D451/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/08 , C07D513/04 , C12N9/99
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
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9.发明公开C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 有权c-Met蛋白激酶抑制剂来治疗增生性疾病
公开(公告)号：EP2004625A2
公开(公告)日：2008-12-24
申请号：EP07753626.6
申请日：2007-03-21
发明人： LAUFFER, David, J. , DAVIES, Robert, J. , STAMOS, Dean , ARONOV, Alexander , DEININGER, David, D. , GREY, Ronald, Jr. , XU, Jinwang , LI, Pan , LEDFORD, Brian , FARMER, Luc , BETHIEL, Randy, Scott , JACOBS, Dylan , MCGINTY, Kira
IPC分类号： C07D401/04 , C07D403/04 , C07D417/04 , C07D471/04 , A61K31/4439 , A61K31/497 , A61K35/00 , A61P35/04
CPC分类号： C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D451/02 , C07D451/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/08 , C07D513/04 , C12N9/99
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
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