公开(公告)号：EP4176888A1

公开(公告)日：2023-05-10

申请号：EP22195181.7

申请日：2009-11-13

申请人： ViaCyte, Inc.

发明人： MARTINSON, Laura ,  GREEN, Chad ,  KROON, Evert ,  AGULNICK, Alan ,  KELLY, Olivia ,  BAETGE, Emmanuel E.

IPC分类号： A61K35/39 ,  C12N11/00 ,  C12N5/071 ,  A61L27/36 ,  A61P5/50

摘要： The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.

公开(公告)号：EP2356227A2

公开(公告)日：2011-08-17

申请号：EP09826863.4

申请日：2009-11-13

申请人： VIACYTE, INC.

发明人： MARTINSON, Laura ,  GREEN, Chad ,  KROON, Evert ,  AGULNICK, Alan ,  KELLY, Olivia ,  D'AMOUR, Kevin ,  BAETGE, Emmanuel E.

IPC分类号： C12N11/00 ,  C12N5/071 ,  A61K35/39

CPC分类号： A61L27/3804 ,  A01N1/0221 ,  A61F2/022 ,  A61K35/39 ,  A61K38/28 ,  A61K2035/126 ,  A61L27/14 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/62 ,  A61L2300/64 ,  A61M5/00 ,  A61M31/00 ,  A61M31/002 ,  A61M2202/07 ,  A61M2205/04 ,  C12N5/0676 ,  C12N5/0678 ,  C12N2501/115 ,  C12N2501/117 ,  C12N2501/119 ,  C12N2501/16 ,  C12N2501/19 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2506/02

摘要： The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.

公开(公告)号：EP3584311A1

公开(公告)日：2019-12-25

申请号：EP19179403.1

申请日：2006-10-27

申请人： VIACYTE, INC.

发明人： D'AMOUR, Kevin ,  AGULNICK, Alan D. ,  ELIAZER, Susan ,  BAETGE, Emmanuel E.

IPC分类号： C12N5/073 ,  C12N5/0735 ,  C07K16/18

摘要： Disclosed herein are cell cultures comprising dorsal and/or ventral PDX1-positive foregut endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified dorsal and/or ventral PDX1-positive foregut endoderm cells as well as methods for enriching, isolating and purifying dorsal and/or ventral PDX1-positive foregut endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of dorsal and/or ventral PDX1-positive foregut endoderm cells, are also disclosed.

公开(公告)号：EP3505622A1

公开(公告)日：2019-07-03

申请号：EP19151982.6

申请日：2005-07-08

申请人： VIACYTE, INC.

发明人： AGULNICK, Alan D. ,  BAETGE, Emmanuel E. ,  D'AMOUR, Kevin Allen ,  ELIAZER, Susan ,  KROON, Evert

IPC分类号： C12N5/073 ,  C12N5/0735

摘要： This disclosure relates to compositions comprising human preprimitive streak cells and/or human mesendoderm cells as well as methods for their production. Additionally, disclosed herein are methods of identifying factors useful in the further differentiation of preprimitive streak and mesendoderm cell types.

公开(公告)号：EP3363444A1

公开(公告)日：2018-08-22

申请号：EP18163933.7

申请日：2009-11-13

申请人： VIACYTE, INC.

发明人： MARTINSON, Laura ,  GREEN, Chad ,  KROON, Evert ,  AGULNICK, Alan ,  KELLY, Olivia ,  BAETGE, Emmanuel E.

IPC分类号： A61K35/39 ,  C12N11/00 ,  C12N5/071 ,  A61L27/36 ,  A61P5/50

CPC分类号： A61L27/3804 ,  A01N1/0221 ,  A61F2/022 ,  A61K35/39 ,  A61K38/28 ,  A61K2035/126 ,  A61L27/14 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/62 ,  A61L2300/64 ,  A61M5/00 ,  A61M31/00 ,  A61M31/002 ,  A61M2202/07 ,  A61M2205/04 ,  C12N5/0676 ,  C12N5/0678 ,  C12N2501/115 ,  C12N2501/117 ,  C12N2501/119 ,  C12N2501/16 ,  C12N2501/19 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2506/02

摘要： The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.

公开(公告)号：EP2356227B1

公开(公告)日：2018-03-28

申请号：EP09826863.4

申请日：2009-11-13

申请人： VIACYTE, INC.

发明人： MARTINSON, Laura ,  GREEN, Chad ,  KROON, Evert ,  AGULNICK, Alan ,  KELLY, Olivia ,  BAETGE, Emmanuel E.

IPC分类号： A61K35/39 ,  C12N11/00 ,  C12N5/071 ,  A61L27/36 ,  A61P5/50

CPC分类号： A61L27/3804 ,  A01N1/0221 ,  A61F2/022 ,  A61K35/39 ,  A61K38/28 ,  A61K2035/126 ,  A61L27/14 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/62 ,  A61L2300/64 ,  A61M5/00 ,  A61M31/00 ,  A61M31/002 ,  A61M2202/07 ,  A61M2205/04 ,  C12N5/0676 ,  C12N5/0678 ,  C12N2501/115 ,  C12N2501/117 ,  C12N2501/119 ,  C12N2501/16 ,  C12N2501/19 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2506/02

摘要： The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.