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公开(公告)号：EP2421957A2
公开(公告)日：2012-02-29
申请号：EP10767801.3
申请日：2010-04-22
申请人： VIACYTE, INC.
CPC分类号： C12N5/0676 , C12N5/0678 , C12N2500/25 , C12N2501/11 , C12N2501/117 , C12N2501/15 , C12N2501/16 , C12N2501/385 , C12N2501/41 , C12N2501/70 , C12N2501/727 , C12N2506/45
摘要： Methods and cell culture compositions, in particular, pancreatic cell culture methods and compositions, derived from dedifferentiated human reprogrammed pluripotent stem cells, such as, induced pluripotent stem (iPS) cells.
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公开(公告)号：EP4176888A1
公开(公告)日：2023-05-10
申请号：EP22195181.7
申请日：2009-11-13
申请人： ViaCyte, Inc.
发明人： MARTINSON, Laura , GREEN, Chad , KROON, Evert , AGULNICK, Alan , KELLY, Olivia , BAETGE, Emmanuel E.
摘要： The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
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公开(公告)号：EP2356213B1
公开(公告)日：2019-05-29
申请号：EP08878030.9
申请日：2008-11-04
申请人： VIACYTE, INC.
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4.发明公开IN VITRO DIFFERENTIATION OF PLURIPOTENT STEM CELLS TO PANCREATIC ENDODERM CELLS (PEC) AND ENDOCRINE CELLS 审中-公开多能干细胞体外分化胰腺内胚层（PEC）和内分泌细胞
公开(公告)号：EP2970899A1
公开(公告)日：2016-01-20
申请号：EP14721621.2
申请日：2014-03-13
申请人： ViaCyte, Inc.
发明人： AGULNICK, Alan , D'AMOUR, Kevin
IPC分类号： C12N5/0735
CPC分类号： A61K35/39 , A61K35/545 , C12N5/0676 , C12N5/0678 , C12N2500/25 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/195 , C12N2501/385 , C12N2501/415 , C12N2501/727 , C12N2501/998 , C12N2501/999 , C12N2506/02 , C12N2506/22 , C12N2506/45 , C12N2533/90 , G01N33/6893 , G01N2333/62 , G01N2800/042 , G01N2800/52
摘要： A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation.
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公开(公告)号：EP3521418A1
公开(公告)日：2019-08-07
申请号：EP19165436.7
申请日：2014-03-13
申请人： ViaCyte, Inc
发明人： AGULNICK, Alan , D'AMOUR, Kevin
IPC分类号： C12N5/0735 , A61K35/545 , A61K35/39 , C12N5/071
摘要： An in vitro cell culture comprising human cells. At least 10% of the human cells are unipotent immature beta cells that co-express INS and NKX6.1 and do not substantially express NGN3.
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公开(公告)号：EP2970899B1
公开(公告)日：2019-05-08
申请号：EP14721621.2
申请日：2014-03-13
申请人： ViaCyte, Inc.
发明人： AGULNICK, Alan , D'AMOUR, Kevin
IPC分类号： C12N5/0735 , C12N5/071 , A61K35/545 , A61K35/39 , G01N33/68
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7.发明公开
公开(公告)号：EP2356227A2
公开(公告)日：2011-08-17
申请号：EP09826863.4
申请日：2009-11-13
申请人： VIACYTE, INC.
发明人： MARTINSON, Laura , GREEN, Chad , KROON, Evert , AGULNICK, Alan , KELLY, Olivia , D'AMOUR, Kevin , BAETGE, Emmanuel E.
CPC分类号： A61L27/3804 , A01N1/0221 , A61F2/022 , A61K35/39 , A61K38/28 , A61K2035/126 , A61L27/14 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/62 , A61L2300/64 , A61M5/00 , A61M31/00 , A61M31/002 , A61M2202/07 , A61M2205/04 , C12N5/0676 , C12N5/0678 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/16 , C12N2501/19 , C12N2501/385 , C12N2501/41 , C12N2501/415 , C12N2506/02
摘要： The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
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公开(公告)号：EP2421957B1
公开(公告)日：2020-11-18
申请号：EP10767801.3
申请日：2010-04-22
申请人： VIACYTE, INC.
IPC分类号： C12N5/071
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公开(公告)号：EP3363444A1
公开(公告)日：2018-08-22
申请号：EP18163933.7
申请日：2009-11-13
申请人： VIACYTE, INC.
发明人： MARTINSON, Laura , GREEN, Chad , KROON, Evert , AGULNICK, Alan , KELLY, Olivia , BAETGE, Emmanuel E.
CPC分类号： A61L27/3804 , A01N1/0221 , A61F2/022 , A61K35/39 , A61K38/28 , A61K2035/126 , A61L27/14 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/62 , A61L2300/64 , A61M5/00 , A61M31/00 , A61M31/002 , A61M2202/07 , A61M2205/04 , C12N5/0676 , C12N5/0678 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/16 , C12N2501/19 , C12N2501/385 , C12N2501/41 , C12N2501/415 , C12N2506/02
摘要： The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
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10.发明授权
公开(公告)号：EP2356227B1
公开(公告)日：2018-03-28
申请号：EP09826863.4
申请日：2009-11-13
申请人： VIACYTE, INC.
发明人： MARTINSON, Laura , GREEN, Chad , KROON, Evert , AGULNICK, Alan , KELLY, Olivia , BAETGE, Emmanuel E.
CPC分类号： A61L27/3804 , A01N1/0221 , A61F2/022 , A61K35/39 , A61K38/28 , A61K2035/126 , A61L27/14 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/62 , A61L2300/64 , A61M5/00 , A61M31/00 , A61M31/002 , A61M2202/07 , A61M2205/04 , C12N5/0676 , C12N5/0678 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/16 , C12N2501/19 , C12N2501/385 , C12N2501/41 , C12N2501/415 , C12N2506/02
摘要： The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
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