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1.发明公开USE OF OPRI LIPOPROTEIN FROM PSEUDOMONAS AS A TH1 INDUCING NATURAL ADJUVANT FOR HETEROLOGOUS ANTIGENS 有权USE OPRI脂蛋白OFF假单胞菌ALS TH1诱导异源抗原自然科学佐剂
公开(公告)号：EP1255562A2
公开(公告)日：2002-11-13
申请号：EP01921281.0
申请日：2001-02-13
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K2039/523 , A61K2039/55544 , A61K2039/57 , C07K14/21 , C07K14/44 , C07K16/10 , C07K2319/00 , Y02A50/41 , Y10S424/823 , Y10S424/824 , Y10S424/825 , Y10S424/826 , Y10S424/828 , Y10S424/829
摘要： The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates specifically to the use of OprI-antigen fusion proteins to elicit the Type-1 response. More particularly, the present invention is directed to pharmaceutical formulations comprising OprI and/or OprI fusion proteins, optionally together with a suitable excipient, to stimulate the Th1 dependent, cellular immune response.
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2.发明授权USE OF OPRI LIPOPROTEIN FROM PSEUDOMONAS AS A TH1 INDUCING NATURAL ADJUVANT FOR HETEROLOGOUS ANTIGENS 有权USE OPRI脂蛋白OFF假单胞菌ALS TH1诱导异源抗原自然科学佐剂
公开(公告)号：EP1255562B1
公开(公告)日：2008-01-16
申请号：EP01921281.0
申请日：2001-02-13
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K2039/523 , A61K2039/55544 , A61K2039/57 , C07K14/21 , C07K14/44 , C07K16/10 , C07K2319/00 , Y02A50/41 , Y10S424/823 , Y10S424/824 , Y10S424/825 , Y10S424/826 , Y10S424/828 , Y10S424/829
摘要： The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates specifically to the use of OprI-antigen fusion proteins to elicit the Type-1 response. More particularly, the present invention is directed to pharmaceutical formulations comprising OprI and/or OprI fusion proteins, optionally together with a suitable excipient, to stimulate the Th1 dependent, cellular immune response.
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3.发明公开
公开(公告)号：EP1051184A1
公开(公告)日：2000-11-15
申请号：EP99907421.4
申请日：1999-01-26
发明人： CORNELIS, Pierre , DE VOS, Daniel
IPC分类号： A61K33/24
CPC分类号： A61K33/24 , Y02A50/473
摘要： The present invention relates to the use of multivalent transition elements and/or salts thereof in a pharmaceutical composition to inhibit bacterial or yeast growth. Especially bacterial Pseudomonas growth is inhibited by using said pharmaceutical composition comprising vanadium and/or a salt thereof. Said vanadium or a vanadium salt is incorporated in a pharmaceutical composition as an essential element whereupon this pharmaceutical is applied for instance to burn-wound patients or patients having ulcers like diabetic foot ulcers.
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