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1.发明授权USE OF OPRI LIPOPROTEIN FROM PSEUDOMONAS AS A TH1 INDUCING NATURAL ADJUVANT FOR HETEROLOGOUS ANTIGENS 有权USE OPRI脂蛋白OFF假单胞菌ALS TH1诱导异源抗原自然科学佐剂
公开(公告)号：EP1255562B1
公开(公告)日：2008-01-16
申请号：EP01921281.0
申请日：2001-02-13
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K2039/523 , A61K2039/55544 , A61K2039/57 , C07K14/21 , C07K14/44 , C07K16/10 , C07K2319/00 , Y02A50/41 , Y10S424/823 , Y10S424/824 , Y10S424/825 , Y10S424/826 , Y10S424/828 , Y10S424/829
摘要： The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates specifically to the use of OprI-antigen fusion proteins to elicit the Type-1 response. More particularly, the present invention is directed to pharmaceutical formulations comprising OprI and/or OprI fusion proteins, optionally together with a suitable excipient, to stimulate the Th1 dependent, cellular immune response.
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2.发明公开USE OF OPRI LIPOPROTEIN FROM PSEUDOMONAS AS A TH1 INDUCING NATURAL ADJUVANT FOR HETEROLOGOUS ANTIGENS 有权USE OPRI脂蛋白OFF假单胞菌ALS TH1诱导异源抗原自然科学佐剂
公开(公告)号：EP1255562A2
公开(公告)日：2002-11-13
申请号：EP01921281.0
申请日：2001-02-13
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K2039/523 , A61K2039/55544 , A61K2039/57 , C07K14/21 , C07K14/44 , C07K16/10 , C07K2319/00 , Y02A50/41 , Y10S424/823 , Y10S424/824 , Y10S424/825 , Y10S424/826 , Y10S424/828 , Y10S424/829
摘要： The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates specifically to the use of OprI-antigen fusion proteins to elicit the Type-1 response. More particularly, the present invention is directed to pharmaceutical formulations comprising OprI and/or OprI fusion proteins, optionally together with a suitable excipient, to stimulate the Th1 dependent, cellular immune response.
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公开(公告)号：EP1461085A2
公开(公告)日：2004-09-29
申请号：EP02796755.3
申请日：2002-12-23
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/6853 , A61K47/6899
摘要： The present invention relates to novel immunoconjugates that are devoid of light chains and comprise at least one variable domain of a heavy chain antibody. The immunoconjugates of the present invention can be used for the preparation of a medicament to treat tumours.
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4.发明公开PEPTIDES AND NUCLEIC ACIDS DERIVED FROM $i(EISENIA FOETIDA) AND THE USE THEREOF 审中-公开多肽和核酸OFF蚯蚓和用于治疗锥虫感染
公开(公告)号：EP1042475A2
公开(公告)日：2000-10-11
申请号：EP98965828.1
申请日：1998-12-16
CPC分类号： C07K14/43536 , A61K38/00
摘要： The invention concerns Eisenia foetida polypeptides and peptides, particularly recombinant polypeptides, which are useful in tumour therapy, microbial infection, inflammation or immunology. The invention also relates to a process for preparing the above-mentioned polypeptides and peptides. Furthermore the invention concerns nucleic acids coding for said polypeptides and peptides.
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