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公开(公告)号：EP0431579A2
公开(公告)日：1991-06-12
申请号：EP90123290.0
申请日：1990-12-05
IPC分类号： C07D213/74 , A61K31/44 , A61K31/38 , C07D409/12 , C07D417/12 , C07D333/20 , C07D401/10
CPC分类号： C07D213/74 , C07D401/08 , C07D409/08 , C07D409/12 , C07D417/12
摘要： Substituted cyclohexenes of formula I
are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.摘要翻译： 描述式I的取代的环己烯
以及其制备方法及其药物组合物，其可用作中枢神经系统试剂，并且特别可用作多巴胺能抗精神病药和抗高血压药物以及用于治疗高泌乳素血症 相关病症和中枢神经系统疾病。 -
2.发明公开Substituted cyclohexanols as central nervous system agents 失效取代基Cyclohexanole mit Zentraler Nervensystemwirkung。
公开(公告)号：EP0431580A2
公开(公告)日：1991-06-12
申请号：EP90123291.8
申请日：1990-12-05
IPC分类号： C07D213/74 , A61K31/44 , C07D409/12 , C07D417/12 , C07D401/10 , C07D401/12 , C07D211/82 , C07D405/12
CPC分类号： C07D211/82 , C07D213/74 , C07D213/82 , C07D401/08 , C07D401/12 , C07D405/12 , C07D409/08 , C07D409/12 , C07D417/12
摘要： Substituted cyclohexanols and cyclohexylamines and derivatives thereof of the formula I
as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.摘要翻译： 式I
的取代的环己醇和环己胺及其衍生物以及其制备方法及其药物组合物，其可用作中枢神经系统试剂，并且特别可用作多巴胺能抗精神病药和抗高血压药物 用于治疗高泌乳素血症相关病症和中枢神经系统疾病。 -
公开(公告)号：EP0431579A3
公开(公告)日：1991-12-11
申请号：EP90123290.0
申请日：1990-12-05
IPC分类号： C07D213/74 , A61K31/44 , A61K31/38 , C07D409/12 , C07D417/12 , C07D333/20 , C07D401/10
CPC分类号： C07D213/74 , C07D401/08 , C07D409/08 , C07D409/12 , C07D417/12
摘要： Substituted cyclohexenes of formula I
are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.-
4.发明公开Thiazolo [f]-fused hexahydroquinoline derivatives as dopaminergic agents 失效噻唑并[f] - 六氢喹啉衍生物作为多巴胺能药物
公开(公告)号：EP0260642A3
公开(公告)日：1989-08-09
申请号：EP87113413.6
申请日：1987-09-14
IPC分类号： C07D513/04 , A61K31/435
CPC分类号： C07D471/04 , C07D513/04
摘要： Hetero [f] fused carbocyclic pyridines of the formula I
are described, as well as processes for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.摘要翻译： 描述了式I的杂[f]稠合碳环吡啶以及其制备方法和药物组合物，其可用作对突触前多巴胺受体具有选择性的多巴胺激动剂，并且可用作多巴胺能，抗精神病药和抗高血压药 以及用于治疗高泌乳素血症相关病症和中枢神经系统疾病。
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公开(公告)号：EP0431580B1
公开(公告)日：1995-03-08
申请号：EP90123291.8
申请日：1990-12-05
IPC分类号： C07D213/74 , A61K31/44 , C07D409/12 , C07D417/12 , C07D401/10 , C07D401/12 , C07D211/82 , C07D405/12
CPC分类号： C07D211/82 , C07D213/74 , C07D213/82 , C07D401/08 , C07D401/12 , C07D405/12 , C07D409/08 , C07D409/12 , C07D417/12
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公开(公告)号：EP0345533A1
公开(公告)日：1989-12-13
申请号：EP89109341.1
申请日：1989-05-24
IPC分类号： C07D277/40 , C07D417/06 , C07D417/12 , A61K31/425 , A61K31/435 , A61K31/495
CPC分类号： C07D417/12 , C07D277/40
摘要： Substituted 2-aminothiazoles are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
摘要翻译： 描述了取代的2-氨基噻唑，以及其制备方法及其药物组合物，其可用作对突触前多巴胺受体具有选择性的多巴胺激动剂，并且可用作多巴胺能抗精神病药和抗高血压药以及用于治疗高泌乳素血症 相关病症和中枢神经系统疾病。
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公开(公告)号：EP0431579B1
公开(公告)日：1994-07-27
申请号：EP90123290.0
申请日：1990-12-05
IPC分类号： C07D213/74 , A61K31/44 , A61K31/38 , C07D409/12 , C07D417/12 , C07D333/20 , C07D401/10
CPC分类号： C07D213/74 , C07D401/08 , C07D409/08 , C07D409/12 , C07D417/12
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8.发明公开1,3-Substituted cycloalkenes and cycloalkanes as central nervous system agents 失效1,3-取代基环烯烃和环烷烃，中间体Nervensystemwirkung。
公开(公告)号：EP0545095A1
公开(公告)日：1993-06-09
申请号：EP92118998.1
申请日：1992-11-05
发明人： Caprathe, Bradley William , Downing, Dennis Michael , Jaen, Juan Carlos , Johnson, Stephen Joseph , Smith III, William John , Wise, Lawrence David , Wright, Jonathan , Wustrow, David Juergen
IPC分类号： C07D211/70 , C07D213/74 , A61K31/435 , A61K31/495 , C07D239/42 , C07D295/02 , C07D401/08 , C07D405/08 , C07D409/04 , C07D409/08
CPC分类号： C07D213/74 , C07D211/70 , C07D295/03 , C07D401/08 , C07D405/08 , C07D409/04 , C07D409/08
摘要： 1,3-Substituted cycloalkenes and cycloalkanes of Formula I
Z-CH₂-Y I
wherein Z is
Y is
wherein the meaning of R and m are provided in the description, are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.摘要翻译： 其中Z是
Y的1,3-取代的环烯烃和式I的环烷烃Z是CHEM，其中描述中提供了R和m的含义，以及制备方法 和其药物组合物，其可用作中枢神经系统试剂，并且特别可用作多巴胺能抗精神病药和抗高血压药，以及用于治疗高泌乳素血症相关病症和中枢神经系统疾病。 -
公开(公告)号：EP0431580A3
公开(公告)日：1991-12-11
申请号：EP90123291.8
申请日：1990-12-05
IPC分类号： C07D213/74 , A61K31/44 , C07D409/12 , C07D417/12 , C07D401/10 , C07D401/12 , C07D211/82 , C07D405/12
CPC分类号： C07D211/82 , C07D213/74 , C07D213/82 , C07D401/08 , C07D401/12 , C07D405/12 , C07D409/08 , C07D409/12 , C07D417/12
摘要： Substituted cyclohexanols and cyclohexylamines and derivatives thereof of the formula I
as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.-
10.发明公开Thiazolo [f]-fused hexahydroquinoline derivatives as dopaminergic agents 失效Thiazolo¬f-kondensierte六水chin啉衍生物，多巴胺
公开(公告)号：EP0260642A2
公开(公告)日：1988-03-23
申请号：EP87113413.6
申请日：1987-09-14
IPC分类号： C07D513/04 , A61K31/435
CPC分类号： C07D471/04 , C07D513/04
摘要： Hetero [f] fused carbocyclic pyridines of the formula I
are described, as well as processes for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.摘要翻译： 描述了式I [CHEM]的异构[f]稠合碳环吡啶，以及其制备方法及其药物组合物，其可用作对突触前多巴胺受体具有选择性的多巴胺激动剂，并且可用作多巴胺能抗精神病药 和抗高血压药物以及治疗高泌乳素血症相关病症和中枢神经系统疾病。
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