公开(公告)号：EP3113857A4

公开(公告)日：2017-11-15

申请号：EP15758913

申请日：2015-02-27

申请人： WATERS TECHNOLOGIES CORP

发明人： BROUSMICHE DARRYL W ,  FAIRCHILD JACOB N ,  HILL JASON F ,  ISAAC GIORGIS ,  MORRIS MICHAEL F ,  WYNDHAM KEVIN D

IPC分类号： B01D15/08 ,  B01D15/26 ,  B01J20/32

CPC分类号： B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3234 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/80 ,  C07F7/1836

摘要： The present invention provides a chromatographic stationary phase material various different types of chromatography. One example chromatographic stationary phase is represented by Formula 1 [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition. W can be absent and/or can include hydrogen and/or can include hydroxyl on the surface of X. Q can be bound directly to X and can include a first hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. T can be bound directly to X and can include a second hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. Additionally, Q and T can essentially eliminate chromatographic interaction between the analyte, and X and W, thereby minimizing retention variation over time (drift or change) under chromatographic conditions utilizing low water concentrations.

公开(公告)号：EP2714225A4

公开(公告)日：2014-11-26

申请号：EP12792769

申请日：2012-05-31

申请人： WATERS TECHNOLOGIES CORP

发明人： ISAAC GIORGIS ,  MCDONALD STEPHEN ,  MILLAR ALAN ,  FOUNTAIN KENNETH ,  SHOCKCOR JOHN

IPC分类号： B01D15/32 ,  B01D15/36 ,  B01D15/38

CPC分类号： B01D15/327 ,  B01D15/36 ,  B01D15/3847 ,  G01N30/482

摘要： The present invention provides methods of separating, profiling and analyzing molecular species contained within a biological sample using a high purity chromatographic material (HPCM) comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifiers with the proviso that when the ionizable modifier does not contain a Zwitterion, the ionizable modifier does not contain a quaternary ammonium ion moiety.