公开(公告)号：EP2300611B1

公开(公告)日：2017-08-09

申请号：EP09763816.7

申请日：2009-06-15

申请人： Whitehead Institute for Biomedical Research

发明人： JAENISCH, Rudolf ,  CAREY, Bryce Woodbury

IPC分类号： A01K67/027 ,  G01N33/50 ,  C12N5/0735 ,  C12N15/79 ,  C12N15/85 ,  C12N15/86 ,  C12N5/10 ,  C12N5/074

CPC分类号： C12N15/86 ,  A01K67/0271 ,  C07K14/4705 ,  C12N5/0606 ,  C12N5/0696 ,  C12N15/79 ,  C12N15/85 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2506/11 ,  C12N2506/115 ,  C12N2510/00 ,  C12N2740/15041 ,  C12N2740/15043 ,  C12N2740/16043 ,  C12N2799/027 ,  C12N2800/108 ,  C12N2840/203 ,  G01N33/5008

公开(公告)号：EP2300611A2

公开(公告)日：2011-03-30

申请号：EP09763816.7

申请日：2009-06-15

申请人： Whitehead Institute For Biomedical Research Nine Cambridge Center

发明人： JAENISCH, Rudolf ,  CAREY, Bryce Woodbury

IPC分类号： C12N15/12 ,  C12N15/867 ,  C12N5/10 ,  C12Q1/02

CPC分类号： C12N15/86 ,  A01K67/0271 ,  C07K14/4705 ,  C12N5/0606 ,  C12N5/0696 ,  C12N15/79 ,  C12N15/85 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2506/11 ,  C12N2506/115 ,  C12N2510/00 ,  C12N2740/15041 ,  C12N2740/15043 ,  C12N2740/16043 ,  C12N2799/027 ,  C12N2800/108 ,  C12N2840/203 ,  G01N33/5008

摘要： The disclosure relates to a method of reprogrammlng one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

摘要翻译： 本公开涉及将一种或多种体细胞例如部分分化或完全/终末分化的体细胞重编程为较少分化状态（例如多能或多能状态）的方法。 在进一步的实施方案中，本发明还涉及通过本发明的方法产生的重编程体细胞，包含本发明的重编程体细胞的嵌合动物，所述细胞的用途以及用于鉴定用于重编程体细胞的药物的方法。

公开(公告)号：EP3231869A1

公开(公告)日：2017-10-18

申请号：EP17159873.3

申请日：2009-06-15

申请人： Whitehead Institute for Biomedical Research

发明人： JAENISCH, Rudolph ,  CAREY, Bryce Woodbury

IPC分类号： C12N15/12 ,  C12N15/867 ,  C12N5/10 ,  C12N5/074

CPC分类号： C12N15/86 ,  A01K67/0271 ,  C07K14/4705 ,  C12N5/0606 ,  C12N5/0696 ,  C12N15/79 ,  C12N15/85 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2506/11 ,  C12N2506/115 ,  C12N2510/00 ,  C12N2740/15041 ,  C12N2740/15043 ,  C12N2740/16043 ,  C12N2799/027 ,  C12N2800/108 ,  C12N2840/203 ,  G01N33/5008

摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.