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公开(公告)号：EP1759402B1
公开(公告)日：2015-07-08
申请号：EP05753270.7
申请日：2005-05-20
CPC分类号： H01J49/42 , H01J49/062
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公开(公告)号：EP1766651A2
公开(公告)日：2007-03-28
申请号：EP05752304.5
申请日：2005-05-19
申请人： Whitehouse, Craig M.
CPC分类号： H01J49/165 , B01D61/00 , B01D61/425 , B01D2313/345 , G01N30/7266 , H01J49/0018 , H01J49/167 , Y10T436/212 , Y10T436/24
摘要： Charged droplet spray is formed from a solution with all or a portion of the charged droplet spray current generated from reduction or oxidation (redox) reactions occurring on surfaces removed from the first or sample solution flow path. In one embodiment of the invention, two solution flow channels are separated by a semipermeable membrane. A first or sample solution flowing through the first solution flow channel exchanges cation or anion charged species through the semipermeable membrane with a second solution or gas flowing through the second flow channel. Charge exchange is driven by the electric field applied at the charged droplet sprayer sample solution outlet. Redox reactions occur at an electrode surface in contact with the second solution. The invention increases the control and range of the Electrospray ionization process during ES/MS operation. Alternative embodiments of the invention provide for conducting redox reactions on conductive surfaces removed from the first or sample solution flow path but not separated by semipermeable membranes.
摘要翻译： 从溶液形成带电的液滴喷雾，其中从在第一或样品溶液流动路径上去除的表面上发生还原或氧化（氧化还原）反应产生的所有或一部分带电液滴喷雾电流。 在本发明的一个实施方案中，两个溶液流动通道被半透膜隔开。 流过第一溶液流动通道的第一或样品溶液通过半透膜与穿过第二流动通道的第二溶液或气体交换阳离子或阴离子带电物质。 电荷交换由在带电液滴喷雾器样品溶液出口处施加的电场驱动。 在与第二溶液接触的电极表面处发生氧化还原反应。 本发明增加了ES / MS操作期间电喷雾电离过程的控制和范围。 本发明的替代实施方案提供了在从第一或样品溶液流动路径移除但不被半透膜隔离的导电表面上进行氧化还原反应。
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公开(公告)号：EP1759402A2
公开(公告)日：2007-03-07
申请号：EP05753270.7
申请日：2005-05-20
IPC分类号： H01J49/42
CPC分类号： H01J49/42 , H01J49/062
摘要： Apparatus and methods are provided for trapping, manipulation and transferring ions along RF and DC potential surfaces and through RF ion guides. Potential wells are formed neap RF-field generating surfaces due to the overlap of the radio-frequency (RF) fields and electrostatic fields created by static potentials applied to surrounding electrodes. Ions can be constrained and accumulated overtime in such wells. During confinement, ions may be subjected to various processes, such as accumulation, fragmentation, collisional cooling, focusing, mass-to-charge filtering, spatial separation ion mobility and chemical interactions, leading to improved performance in subsequent processing and analysis steps, such as mass analysis. Alternatively, the motion of ions may be better manipulated during confinement to improve the efficiency of their transport to specific locations, such as an entrance aperture into vacuum from atmospheric pressure or into a subsequent vacuum stage.
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