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公开(公告)号：EP2520286A1
公开(公告)日：2012-11-07
申请号：EP12178127.2
申请日：2008-09-16
申请人： Wockhardt Limited
CPC分类号： A61K9/146 , A61K9/145 , A61K9/1641 , A61K9/4808 , A61K9/5078 , A61K9/5084 , A61K31/192
摘要： The invention relates to pharmaceutical compositions of rhein or diacerein, or salts or esters or prodrugs thereof which are bioequivalent to a 50 mg diacerein formulation marketed under the trade name Art 50 ® . The compositions exhibit no variability in fed and fasted state conditions. The compositions also result in significant reduction in side effects such as, soft stools as compared to Art 50 ® . The invention also relates to the methods for preparing such compositions.
摘要翻译： 本发明涉及大黄酸或双醋瑞因或其盐或酯或前药的药物组合物，其与以商品名Art 50销售的50mg双醋瑞因制剂是生物等效的。 组合物在进食和禁食状态下表现出不变性。 与Art 50®相比，组合物还导致副作用显着降低，例如软性粪便。 本发明还涉及制备这种组合物的方法。
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公开(公告)号：EP2520285A1
公开(公告)日：2012-11-07
申请号：EP12178122.3
申请日：2008-09-16
申请人： Wockhardt Limited
CPC分类号： A61K9/146 , A61K9/145 , A61K9/1641 , A61K9/4808 , A61K9/5078 , A61K9/5084 , A61K31/192
摘要： The invention relates to pharmaceutical compositions of rhein or diacerein, or salts or esters or prodrugs thereof which are bioequivalent to a 50 mg diacerein formulation marketed under the trade name Art 50 ® . The compositions exhibit no variability in fed and fasted state conditions. The compositions also result in significant reduction in side effects such as, soft stools as compared to Art 50 ® . The invention also relates to the methods for preparing such compositions.
摘要翻译： 本发明涉及大黄酸或双醋瑞因或其盐或酯或其前药的药物组合物，其与以商品名Art 50？出售的50mg双醋瑞因制剂生物等效。 该组合物在进食和禁食状态条件下没有变化。 与Art50®相比，该组合物还可以显着减少副作用，例如软便。 本发明还涉及制备这种组合物的方法。
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公开(公告)号：EP2520284A1
公开(公告)日：2012-11-07
申请号：EP12178119.9
申请日：2008-09-16
申请人： Wockhardt Limited
CPC分类号： A61K9/146 , A61K9/145 , A61K9/1641 , A61K9/4808 , A61K9/5078 , A61K9/5084 , A61K31/192
摘要： The invention relates to pharmaceutical compositions of rhein or diacerein, or salts or esters or prodrugs thereof which are bioequivalent to a 50 mg diacerein formulation marketed under the trade name Art 50 ® , The compositions exhibit no variability in fed and fasted state conditions. The compositions also result in significant reduction in side effects such as, soft stools as compared to Art 50 ® . The invention also relates to the methods for preparing such compositions.
摘要翻译： 本发明涉及大黄酸或双醋瑞因或其盐或酯或前药的药物组合物，其与以商品名“Art 50”销售的50mg双醋瑞因制剂是生物等效的。该组合物在进食和禁食状态下表现出不变性。 与Art 50®相比，组合物还导致副作用显着降低，例如软性粪便。 本发明还涉及制备这种组合物的方法。
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公开(公告)号：EP2520283A1
公开(公告)日：2012-11-07
申请号：EP12178105.8
申请日：2008-09-16
申请人： Wockhardt Limited
CPC分类号： A61K9/146 , A61K9/145 , A61K9/1641 , A61K9/4808 , A61K9/5078 , A61K9/5084 , A61K31/192
摘要： The invention relates to pharmaceutical compositions of rhein or diacerein, or salts or esters or prodrugs thereof which are bioequivalent to a 50 mg diacerein formulation marketed under the trade name Art 50 ® . The compositions exhibit no variability in fed and fasted state conditions. The compositions also result in significant reduction in side effects such as, soft stools as compared to Art 50 ® . The invention also relates to the methods for preparing such compositions.
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