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公开(公告)号：EP2471516A2
公开(公告)日：2012-07-04
申请号：EP12153403.6
申请日：2008-09-13
申请人： Wockhardt Limited
发明人： Dabre, Rahul , Jain, Girish, Kumar , Estanove, Cyril , Pruvost, François , Sandal, Roshanlal , Mandaogade, Prashant , Nakhat, Premchand
IPC分类号： A61K9/16 , A61K31/192 , A61K31/222 , A61K47/48 , C08B37/00 , C08L5/16 , B82Y5/00
CPC分类号： A61K31/235 , A61K9/145 , A61K9/146 , A61K9/1623 , A61K9/2018 , A61K9/4858 , A61K31/192 , A61K31/222 , A61K47/26 , A61K47/6951 , B82Y5/00 , C08B37/0015 , C08L5/16
摘要： The invention relates to pharmaceutical compositions comprising rhein or diacerein or salts or esters or prodrugs thereof, optionally with one or more pharmaceutically acceptable excipients. The invention also relates to methods for preparing such compositions.
摘要翻译： 本发明涉及药物组合物，其包含大黄酸或双醋瑞因或其盐或酯或前药，任选地与一种或多种药学上可接受的赋形剂。 本发明还涉及制备这种组合物的方法。
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公开(公告)号：EP2520284A1
公开(公告)日：2012-11-07
申请号：EP12178119.9
申请日：2008-09-16
申请人： Wockhardt Limited
CPC分类号： A61K9/146 , A61K9/145 , A61K9/1641 , A61K9/4808 , A61K9/5078 , A61K9/5084 , A61K31/192
摘要： The invention relates to pharmaceutical compositions of rhein or diacerein, or salts or esters or prodrugs thereof which are bioequivalent to a 50 mg diacerein formulation marketed under the trade name Art 50 ® , The compositions exhibit no variability in fed and fasted state conditions. The compositions also result in significant reduction in side effects such as, soft stools as compared to Art 50 ® . The invention also relates to the methods for preparing such compositions.
摘要翻译： 本发明涉及大黄酸或双醋瑞因或其盐或酯或前药的药物组合物，其与以商品名“Art 50”销售的50mg双醋瑞因制剂是生物等效的。该组合物在进食和禁食状态下表现出不变性。 与Art 50®相比，组合物还导致副作用显着降低，例如软性粪便。 本发明还涉及制备这种组合物的方法。
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公开(公告)号：EP2520283A1
公开(公告)日：2012-11-07
申请号：EP12178105.8
申请日：2008-09-16
申请人： Wockhardt Limited
CPC分类号： A61K9/146 , A61K9/145 , A61K9/1641 , A61K9/4808 , A61K9/5078 , A61K9/5084 , A61K31/192
摘要： The invention relates to pharmaceutical compositions of rhein or diacerein, or salts or esters or prodrugs thereof which are bioequivalent to a 50 mg diacerein formulation marketed under the trade name Art 50 ® . The compositions exhibit no variability in fed and fasted state conditions. The compositions also result in significant reduction in side effects such as, soft stools as compared to Art 50 ® . The invention also relates to the methods for preparing such compositions.
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公开(公告)号：EP2471516A3
公开(公告)日：2012-12-26
申请号：EP12153403.6
申请日：2008-09-13
申请人： Wockhardt Limited
发明人： Dabre, Rahul , Jain, Girish, Kumar , Estanove, Cyril , Pruvost, François , Sandal, Roshanlal , Mandaogade, Prashant , Nakhat, Premchand , Pruvost, Marie Francois
IPC分类号： A61K9/14 , A61K31/192 , A61K31/222 , A61K47/48 , C08B37/00 , C08L5/16 , B82Y5/00 , A61K9/16 , A61K9/48 , A61K9/20
CPC分类号： A61K31/235 , A61K9/145 , A61K9/146 , A61K9/1623 , A61K9/2018 , A61K9/4858 , A61K31/192 , A61K31/222 , A61K47/26 , A61K47/6951 , B82Y5/00 , C08B37/0015 , C08L5/16
摘要： The invention relates to pharmaceutical compositions comprising rhein or diacerein or salts or esters or prodrugs thereof, optionally with one or more pharmaceutically acceptable excipients. The invention also relates to methods for preparing such compositions.
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公开(公告)号：EP2471517A2
公开(公告)日：2012-07-04
申请号：EP12153481.2
申请日：2008-09-13
申请人： Wockhardt Limited
发明人： Dabre, Rahul , Jain, Girish, Kumar , Estanove, Cyril , Pruvost, François , Sandal, Roshanlal , Mandaogade, Prashant , Nakhat, Premchand
IPC分类号： A61K9/16 , A61K31/192 , A61K31/222 , A61K47/48 , B82Y5/00
CPC分类号： A61K31/235 , A61K9/145 , A61K9/146 , A61K9/1623 , A61K9/2018 , A61K9/4858 , A61K31/192 , A61K31/222 , A61K47/26 , A61K47/6951 , B82Y5/00 , C08B37/0015 , C08L5/16
摘要： The invention relates to pharmaceutical compositions comprising rhein or diacerein or salts or esters or prodrugs thereof, optionally with one or more pharmaceutically acceptable excipients. The invention also relates to methods for preparing such compositions.
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公开(公告)号：EP2471517A3
公开(公告)日：2012-12-26
申请号：EP12153481.2
申请日：2008-09-13
申请人： Wockhardt Limited
发明人： Dabre, Rahul , Jain, Girish, Kumar , Estanove, Cyril , Pruvost, François , Sandal, Roshanlal , Mandaogade, Prashant , Nakhat, Premchand , Pruvost, Marie Francois
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/192 , A61K31/222 , A61K47/48 , B82Y5/00 , C08L5/16 , C08B37/00
CPC分类号： A61K31/235 , A61K9/145 , A61K9/146 , A61K9/1623 , A61K9/2018 , A61K9/4858 , A61K31/192 , A61K31/222 , A61K47/26 , A61K47/6951 , B82Y5/00 , C08B37/0015 , C08L5/16
摘要： The invention relates to pharmaceutical compositions comprising rhein or diacerein or salts or esters or prodrugs thereof, optionally with one or more pharmaceutically acceptable excipients. The invention also relates to methods for preparing such compositions.
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公开(公告)号：EP2520285A1
公开(公告)日：2012-11-07
申请号：EP12178122.3
申请日：2008-09-16
申请人： Wockhardt Limited
CPC分类号： A61K9/146 , A61K9/145 , A61K9/1641 , A61K9/4808 , A61K9/5078 , A61K9/5084 , A61K31/192
摘要： The invention relates to pharmaceutical compositions of rhein or diacerein, or salts or esters or prodrugs thereof which are bioequivalent to a 50 mg diacerein formulation marketed under the trade name Art 50 ® . The compositions exhibit no variability in fed and fasted state conditions. The compositions also result in significant reduction in side effects such as, soft stools as compared to Art 50 ® . The invention also relates to the methods for preparing such compositions.
摘要翻译： 本发明涉及大黄酸或双醋瑞因或其盐或酯或其前药的药物组合物，其与以商品名Art 50？出售的50mg双醋瑞因制剂生物等效。 该组合物在进食和禁食状态条件下没有变化。 与Art50®相比，该组合物还可以显着减少副作用，例如软便。 本发明还涉及制备这种组合物的方法。
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公开(公告)号：EP2471515A3
公开(公告)日：2012-12-26
申请号：EP12153402.8
申请日：2008-09-13
申请人： Wockhardt Limited
发明人： Dabre, Rahul , Jain, Girish, Kumar , Estanove, Cyril , Pruvost, François , Sandal, Roshanlal , Mandaogade, Prashant , Nakahat, Premchand
IPC分类号： A61K9/14 , A61K31/192 , A61K31/222 , A61K47/48 , B82Y5/00 , C08L5/16 , A61K9/16 , A61K9/48 , A61K9/20 , C08B37/00
CPC分类号： A61K31/235 , A61K9/145 , A61K9/146 , A61K9/1623 , A61K9/2018 , A61K9/4858 , A61K31/192 , A61K31/222 , A61K47/26 , A61K47/6951 , B82Y5/00 , C08B37/0015 , C08L5/16
摘要： The invention relates to pharmaceutical compositions comprising rhein or diacerein or salts or esters or prodrugs thereof, optionally with one or more pharmaceutically acceptable excipients. The invention also relates to methods for preparing such compositions.
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公开(公告)号：EP2520286A1
公开(公告)日：2012-11-07
申请号：EP12178127.2
申请日：2008-09-16
申请人： Wockhardt Limited
CPC分类号： A61K9/146 , A61K9/145 , A61K9/1641 , A61K9/4808 , A61K9/5078 , A61K9/5084 , A61K31/192
摘要： The invention relates to pharmaceutical compositions of rhein or diacerein, or salts or esters or prodrugs thereof which are bioequivalent to a 50 mg diacerein formulation marketed under the trade name Art 50 ® . The compositions exhibit no variability in fed and fasted state conditions. The compositions also result in significant reduction in side effects such as, soft stools as compared to Art 50 ® . The invention also relates to the methods for preparing such compositions.
摘要翻译： 本发明涉及大黄酸或双醋瑞因或其盐或酯或前药的药物组合物，其与以商品名Art 50销售的50mg双醋瑞因制剂是生物等效的。 组合物在进食和禁食状态下表现出不变性。 与Art 50®相比，组合物还导致副作用显着降低，例如软性粪便。 本发明还涉及制备这种组合物的方法。
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公开(公告)号：EP2471515A2
公开(公告)日：2012-07-04
申请号：EP12153402.8
申请日：2008-09-13
申请人： Wockhardt Limited
发明人： Dabre, Rahul , Jain, Girish, Kumar , Estanove, Cyril , Pruvost, François , Sandal, Roshanlal , Mandaogade, Prashant , Nakahat, Premchand
IPC分类号： A61K9/16 , A61K31/192 , A61K31/222 , B82Y5/00
CPC分类号： A61K31/235 , A61K9/145 , A61K9/146 , A61K9/1623 , A61K9/2018 , A61K9/4858 , A61K31/192 , A61K31/222 , A61K47/26 , A61K47/6951 , B82Y5/00 , C08B37/0015 , C08L5/16
摘要： The invention relates to pharmaceutical compositions comprising rhein or diacerein or salts or esters or prodrugs thereof, optionally with one or more pharmaceutically acceptable excipients. The invention also relates to methods for preparing such compositions.
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