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1.发明公开2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR ß-SECRETASE MODULATION 审中-公开2-氨基-5- PIPERIDINYLIMIDAZOLON化合物及其使用SS-分泌酶调节
公开(公告)号：EP1966185A2
公开(公告)日：2008-09-10
申请号：EP06849104.2
申请日：2006-12-14
申请人： Wyeth
发明人： ZHOU, Ping , BERNOTAS, Ronald, Charles , LI, Yanfang , NOWAK, Pawel, Wojciech , COLE, Derek, Cecil , MANAS, Eric, Steven , FAN, Yi , YAN, Yinfa
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , A61K31/454 , A61K31/506 , A61P25/28
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14
摘要： The present invention provides a 2-amino-5-piperidinylimidazolone compound of formula (I) The present invention also provides methods and compositions for the inhibition of ß-secretase (BACE) and the treatment of ß-amyloid deposits and neurofibrillary tangles.
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2.发明公开
公开(公告)号：EP1551840A1
公开(公告)日：2005-07-13
申请号：EP03765726.9
申请日：2003-07-17
申请人： Wyeth
发明人： BERNOTAS, Ronald, Charles , LENICEK, Steven, Edward , ELOKDAH, Hassan, Mahmoud , LI, David, Zenan
IPC分类号： C07D487/04 , A61K31/454 , A61P25/00
CPC分类号： C07D487/08 , A61K31/454 , A61K31/4745 , A61K31/498 , A61K31/503
摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译： 本发明提供了式（I）化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统病症的用途。
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3.发明公开1-HETEROCYCLYLALKYL-3-SULFONYLINDOLE OR -INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开作为5-羟基烟酰胺-6配体的1-杂芳基烷基-3-磺酰基吲哚或哒唑衍生物
公开(公告)号：EP1554244A1
公开(公告)日：2005-07-20
申请号：EP03765725.1
申请日：2003-07-17
申请人： Wyeth
IPC分类号： C07D209/36 , A61P25/00 , A61K31/404
CPC分类号： C07D401/04 , A61K31/404 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D409/14
摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译： 本发明提供了式（I）化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统病症的用途。
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4.发明公开1-(AMINOALKYL)-3-SULFONYLAZAINDOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 有权1-（氨基烷基）-3- SULFONYLAZAINDOLE ALS 5-羟色胺-6配体的
公开(公告)号：EP1509522A1
公开(公告)日：2005-03-02
申请号：EP03734366.2
申请日：2003-06-03
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61P25/00 , A61P25/22 , A61P25/28
CPC分类号： C07D519/04 , A61K31/4745 , A61K31/519 , C07D471/04 , C07D519/00
摘要： The present invention provides a compound of formula (I) and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
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5.发明公开
公开(公告)号：EP2367801A1
公开(公告)日：2011-09-28
申请号：EP09756223.5
申请日：2009-11-17
申请人： Wyeth LLC
发明人： TRAVINS, Jeremy, Mark , BERNOTAS, Ronald, Charles , WROBEL, Jay, Edward , KAUFMAN, David, Harry , HU, Baihua , JETTER, James, Winfield , O'NEILL, David, John , MANN, Charles, William
IPC分类号： C07D239/72 , A61K31/517 , A61P3/00 , A61P9/10 , A61P29/00
CPC分类号： C07D239/72
摘要： Disclosed are polar quinazoline-based modulators of Liver X receptors (LXRs) and related methods. The modulators include compounds of formula (I): INSERT FORMULA HERE AS IT APPEARS IN WRITTEN FORM IN THE SPECIFICATION (I) in which, R1, R2, R3, R4, R5, R6, R22, R23, R24, R25, R26, R27, R28, R29, W, W1, W2, Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, Rj, Rm, Rn, Ro, Rp, Rq, Rr, Rs, Rt, Ru, and n can be as defined anywhere herein. In general, these compounds can be used for treating or preventing one or more diseases, disorders, conditions or symptoms mediated by LXRs.
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6.发明公开SULFONYLDIHYDRO- BENZIMIDAZOLONE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开作为5-羟基硝胺-6配体的磺酰基二氢 - 苯并咪唑酮化合物
公开(公告)号：EP1654258A1
公开(公告)日：2006-05-10
申请号：EP04778650.4
申请日：2004-07-19
申请人： Wyeth
IPC分类号： C07D409/12 , C07D513/04 , C07D235/26 , C07D417/14 , A61K31/4184 , A61P25/00
CPC分类号： A61K31/4184 , C07D235/26 , C07D401/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention provides a compound of formula (I) and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译： 本发明提供了式（I）化合物及其在治疗性治疗与5-HT 6受体相关或受其影响的中枢神经系统疾病中的用途。
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7.发明公开1-(AMINOALKYL)-3-SULFONYLINDOLE AND -INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 有权1-（氨基烷基）-3-吲唑SULFONYLINDOL和衍生ALS 5-羟色胺-6配体的
公开(公告)号：EP1509501A1
公开(公告)日：2005-03-02
申请号：EP03736818.0
申请日：2003-06-03
申请人： Wyeth
发明人： BERNOTAS, Ronald, Charles , LENICEK, Steven, Edward , ANTANE, Schuyler, A. , ZHOU, Ping , LI, Yanfang
IPC分类号： C07D209/30 , C07D231/56 , C07D403/12 , C07D409/12 , C07D513/04 , A61K31/40 , A61P25/00
CPC分类号： C07D209/48 , C07D209/08 , C07D209/30 , C07D231/56 , C07D403/12 , C07D409/12 , C07D513/04
摘要： The present invention provides compounds of formula (I) and the use thereof for the treatment of central nervous system disorders related to or affected by the 5-HT6 receptor.
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公开(公告)号：EP2142517A2
公开(公告)日：2010-01-13
申请号：EP08827131.7
申请日：2008-05-15
申请人： Wyeth
发明人： BERNOTAS, Ronald, Charles , ULLRICH, John, William , TRAVINS, Jeremy, Mark , WROBEL, Jay, E. , UNWALLA, Rayomand, J.
IPC分类号： C07D239/74 , A61K31/33 , A61P29/00
CPC分类号： C07D239/74
摘要： This invention relates generally to quinazoline-based modulators of Liver X receptors (LXRs) and related methods.
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9.发明公开OXAZOLIDONE DERIVATIVES AS PR MODULATORS 审中-公开OXAZOLIDON-DERIVATE ALS PROGESTERONREZEPTORMODULATOREN
公开(公告)号：EP2054410A2
公开(公告)日：2009-05-06
申请号：EP07836789.3
申请日：2007-08-13
申请人： Wyeth
发明人： COMMONS, Thomas, Joseph , FENSOME, Andrew , HEFFERNAN, Gavin, David , MCCOMAS, Casey, Cameron , WOODWORTH, Richard, Page, Jr. , WEBB, Michael, Byron , MARELLA, Michael, Anthony , MELENSKI, Edward, George , BERNOTAS, Ronald, Charles
IPC分类号： C07D417/04
CPC分类号： C07D417/04 , C07D263/48 , C07D413/04 , C07D417/14 , C07D453/06
摘要： Compounds of the structure (I) are described, wherein R1, R2, R5, R6, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.
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10.发明授权AZAINDOLYLALKYLAMINE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 有权AZAINDOLYLALKYLAMINDERIVATE ALS 5-羟色胺-6配体的
公开(公告)号：EP1456206B1
公开(公告)日：2008-05-21
申请号：EP02795890.9
申请日：2002-12-17
申请人： Wyeth
IPC分类号： C07D471/04 , A61K31/437 , A61P25/28
CPC分类号： C07D471/04 , A61K31/4745
摘要： The present invention provides a compound of formula (I) and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
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