公开(公告)号：EP3299384A1

公开(公告)日：2018-03-28

申请号：EP16795912.1

申请日：2016-05-20

申请人： Xiamen University

发明人： GE, Shengxiang ,  LI, Tingdong ,  JIA, Lianzhi ,  LI, Yijian ,  XUE, Miaoge ,  ZENG, Yuanjun ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C07K14/14 ,  C12N15/46 ,  A61K39/15 ,  A61P31/14

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/15 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/575 ,  A61P1/00 ,  A61P1/12 ,  A61P29/00 ,  A61P31/14 ,  C12N7/00 ,  C12N2720/12322 ,  C12N2720/12334 ,  C12N2720/12351

摘要： The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.

摘要翻译： 本发明涉及截短的轮状病毒VP4蛋白，编码它的序列，其制备方法，以及包含该蛋白的药物组合物和疫苗，其中该蛋白，该药物组合物和疫苗可用于预防，缓解 或治疗轮状病毒感染和轮状病毒感染引起的疾病，如轮状病毒胃肠炎和腹泻。 本发明进一步涉及该蛋白质在制备用于预防，减轻或治疗轮状病毒感染和由轮状病毒感染引起的疾病（例如轮状病毒胃肠炎和腹泻）的药物组合物或疫苗中的用途。

公开(公告)号：EP3981782A1

公开(公告)日：2022-04-13

申请号：EP21194967.2

申请日：2016-05-20

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： GE, Shengxiang ,  LI, Tingdong ,  JIA, Lianzhi ,  LI, Yijian ,  XUE, Miaoge ,  ZENG, Yuanjun ,  ZHANG, Jun ,  XIA, Ningshao ,  PAN, Huirong

IPC分类号： C07K14/14 ,  C12N15/46 ,  A61K39/15 ,  A61P31/14 ,  A61K39/12

摘要： The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.