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1.发明公开Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them 失效氯代乙醇和溴化胆碱衍生物，其制备和药物组合物包括它们
公开(公告)号：EP0584552A3
公开(公告)日：1994-08-17
申请号：EP93111942.4
申请日：1993-07-26
发明人： Scherz, Avigdor , Salomon, Yoram , Fiedor, Leszek
CPC分类号： A61K49/0036 , A61K41/0071 , A61K47/64 , A61K47/6803 , A61K47/6851 , A61K49/00 , A61K49/0052 , A61K49/0056 , C07K14/685 , C07K14/795 , C12N9/18 , C12P17/182
摘要： Conjugates of chlorophyll (Chl) and bacteriochlorophyll (Bchl) derivatives with amino acids, peptides and proteins are provided by the invention.The amino acid, peptide or protein residue is linked to the 17-propionic acid group of a Chl or Bchl residue directly or through a chain.The conjugates are for use as photosensitizers in photodynamic therapy and in diagnostics of tumors. Conjugation with cell-specific ligands, such as hormones, growth factors or tumor-specific antibodies, will target the Chl or Bchl moiety to the tumor site. Thus, conjugates with melanocyte stimulating hormones are suitable for photodynamic therapy of melanoma tumors.
摘要翻译： 本发明提供了具有氨基酸，肽和蛋白质的叶绿素（Chl）和细菌叶绿素（Bchl）衍生物的缀合物。氨基酸，肽或蛋白质残基直接连接到Chl或Bchl残基的17-丙酸基团 通过链。缀合物用作光动力学治疗和肿瘤诊断中的光敏剂。 细胞特异性配体如激素，生长因子或肿瘤特异性抗体的缀合将靶向肿瘤部位的Chl或Bchl部分。 因此，与黑素细胞刺激激素的缀合物适用于黑素瘤肿瘤的光动力学治疗。
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2.发明授权Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them 失效叶绿素和细菌叶绿素衍生物，它们的制备和含有它们的药物组合物
公开(公告)号：EP0584552B1
公开(公告)日：2000-10-11
申请号：EP93111942.4
申请日：1993-07-26
发明人： Scherz, Avigdor , Salomon, Yoram , Fiedor, Leszek
CPC分类号： A61K49/0036 , A61K41/0071 , A61K47/64 , A61K47/6803 , A61K47/6851 , A61K49/00 , A61K49/0052 , A61K49/0056 , C07K14/685 , C07K14/795 , C12N9/18 , C12P17/182
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3.发明公开Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them 失效叶绿素和细菌叶绿素衍生物，它们的制备和含有它们的药物组合物。
公开(公告)号：EP0584552A2
公开(公告)日：1994-03-02
申请号：EP93111942.4
申请日：1993-07-26
发明人： Scherz, Avigdor , Salomon, Yoram , Fiedor, Leszek
CPC分类号： A61K49/0036 , A61K41/0071 , A61K47/64 , A61K47/6803 , A61K47/6851 , A61K49/00 , A61K49/0052 , A61K49/0056 , C07K14/685 , C07K14/795 , C12N9/18 , C12P17/182
摘要： Conjugates of chlorophyll (Chl) and bacteriochlorophyll (Bchl) derivatives with amino acids, peptides and proteins are provided by the invention.The amino acid, peptide or protein residue is linked to the 17-propionic acid group of a Chl or Bchl residue directly or through a chain.The conjugates are for use as photosensitizers in photodynamic therapy and in diagnostics of tumors. Conjugation with cell-specific ligands, such as hormones, growth factors or tumor-specific antibodies, will target the Chl or Bchl moiety to the tumor site. Thus, conjugates with melanocyte stimulating hormones are suitable for photodynamic therapy of melanoma tumors.
摘要翻译： 与氨基酸，肽和蛋白质叶绿素（叶绿素）和细菌叶绿素的缀合物（的Bchl）衍生物由下invention.The氨基酸，肽或蛋白质残基提供链接到叶绿素a和Bchl残基的17-丙酸基团直接或 通过一个链。偶联物用作光动力治疗的光敏剂和在肿瘤中的诊断。 缀合与细胞特异性配体，：如激素，生长因子或肿瘤特异性抗体，将针对叶绿素和Bchl部分至肿瘤部位。 因此，与黑素细胞刺激激素偶联物适合用于黑色素瘤的光动力学治疗。
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