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公开(公告)号：EP3846781A1
公开(公告)日：2021-07-14
申请号：EP19779197.3
申请日：2019-09-05
发明人： FRIEDMAN, Michael , KIRMAYER, David , NUDELMAN, Zakhar , HOFFMAN, Amnon , LAVY, Eran , BAR-HAI, Ayala , GATI, Irith
IPC分类号： A61K9/08 , A61K31/165 , A61K31/43 , A61K31/7048 , A61K47/18 , A61K47/38 , A61P31/04
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公开(公告)号：EP3515411A1
公开(公告)日：2019-07-31
申请号：EP17791465.2
申请日：2017-09-19
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. , Hadasit Medical Research Services and Development Ltd.
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3.发明授权SUSTAINED RELEASE DELIVERY SYSTEMS FOR THE PREVENTION AND TREATMENT OF HEAD AND NECK CANCERS 有权用于预防和治疗头颈癌的持续释放递送系统
公开(公告)号：EP2470179B1
公开(公告)日：2017-11-29
申请号：EP10763453.7
申请日：2010-08-25
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. , Hadasit Medical Research Services and Development Ltd. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： FRIEDMAN, Michael , CZERNINSKI, Rakefet , GUTKIND, Silvio , STEINBERG, Doron , GATI, Irith , NUDELMAN, Zakhar
IPC分类号： A61K31/436 , A61K9/00 , A61K9/20 , A61K9/70 , A61P35/00
CPC分类号： A61K31/436 , A61K9/006 , A61K9/2054 , A61K9/7015
摘要： The present invention discloses a method of treating a head and neck cancer or preventing the development of pre-malignant lesions to this cancer, by administering locally to the oral cavity, a sustained release drug delivery system comprising a drug for the treatment of this cancer or for the prevention of said lesions, and at least one polymer, such that said system is attached to a surface in the oral cavity and remains attached thereto for at least 1 hour, accompanied by release of the drug and maintaining an effective therapeutic concentration thereof in the cavity, for at least 1 hour. Further are disclosed a sustained release drug delivery system and a liquid precursor varnish composition to this system.
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公开(公告)号：EP4084790A1
公开(公告)日：2022-11-09
申请号：EP20838642.5
申请日：2020-12-30
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公开(公告)号：EP2381971B1
公开(公告)日：2016-01-06
申请号：EP10703124.7
申请日：2010-01-12
申请人： Hadasit Medical Research Services & Development Limited , Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
CPC分类号： A61L27/26 , A61L27/3834 , A61L27/502 , A61L31/005 , A61L31/041 , A61L31/141
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6.发明公开FILM-FORMING COMPOSITION FOR A PH-DEPENDANT SUSTAINED RELEASE OF THE ACTIVE AGENT 审中-公开FILMBILDENDE ZUSAMMENSETZUNGFÜREINE PH-ABHÄNGIGVERZÖGERTEWIRKSTOFFFREISETZUNG
公开(公告)号：EP2691085A1
公开(公告)日：2014-02-05
申请号：EP12721938.4
申请日：2012-03-25
发明人： FRIEDMAN, Michael , STEINBERG, Doron , LAVY, Eran
IPC分类号： A61K9/70 , A61K31/155 , A61K31/16 , A61K31/415 , A61L29/08 , A61L31/10 , A61K31/4425
CPC分类号： A61L29/085 , A61K9/0041 , A61K9/7015 , A61K31/085 , A61K31/09 , A61K31/155 , A61K31/4164 , A61K31/4174 , A61K31/4425 , A61K47/10 , A61K47/32 , A61K47/38 , A61L27/34 , A61L27/54 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/602 , A61L2420/02 , A61L2420/06
摘要： The present invention discloses a liquid precursor composition adapted for application on a on a desired surface, this composition comprising : a. at least one therapeutic agent suitable for the treatment or prevention of a disorder or pathological condition, wherein said disorder or pathological condition excludes oral disorders, b. at least one acidic-pH sensitive polymer, c. at least one hydrophobic polymer, and d. a pharmaceutically acceptable volatile solvent, wherein a weight ratio between the at least one hydrophobic polymer and the at least one acidic -pH sensitive polymer is larger than 1.
摘要翻译： 本发明公开了适用于所需表面上的液体前体组合物，该组合物包含：a。 至少一种适于治疗或预防病症或病理状况的治疗剂，其中所述病症或病理状况排除口腔障碍，b。 至少一种酸性pH敏感聚合物，c。 至少一种疏水性聚合物，和d。 药学上可接受的挥发性溶剂，其中所述至少一种疏水性聚合物与所述至少一种酸性pH敏感聚合物之间的重量比大于1。
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公开(公告)号：EP2691081A1
公开(公告)日：2014-02-05
申请号：EP12720287.7
申请日：2012-03-28
发明人： FRIEDMAN, Michael , HOFFMAN, Amnon , LAVY, Eran
IPC分类号： A61K9/10 , A61K47/10 , A61K31/43 , A61K31/496 , A61K31/546 , A61K31/65
CPC分类号： A61K9/06 , A61K9/0024 , A61K9/10 , A61K31/43 , A61K31/496 , A61K31/546 , A61K31/65 , A61K47/10
摘要： A composition which comprises a biologically active agent and a polymer that exhibits a reverse thermal gelation at a physiological temperature, in a carrier, and in which the active agent is in an undissolved form is disclosed herein. Further disclosed herein are methods utilizing the compositions for treating subjects, including non-human subjects, as well as kits for preparing and using a composition. The composition is preferably a sustained release formulation, and is particularly useful for treating animals, where single-dose treatment is desired.
摘要翻译： 本文公开了包含生物活性剂和在生理温度下在载体中表现出反向热凝胶化并且活性剂处于未溶解形式的聚合物的组合物。 本文进一步公开了使用所述组合物治疗受试者（包括非人受试者）的方法，以及用于制备和使用组合物的试剂盒。 该组合物优选是持续释放制剂，并且特别适用于治疗需要单剂量治疗的动物。
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公开(公告)号：EP2560623A1
公开(公告)日：2013-02-27
申请号：EP11723651.3
申请日：2011-04-20
IPC分类号： A61K9/20 , A61K31/473
CPC分类号： A61K9/2068 , A61K31/473 , A61K38/38 , A61K47/42 , A61K2300/00
摘要： Sustained-release formulations comprising huperzine A are disclosed herein. The formulations are for oral administration, and contain a carrier which comprises native albumin. Unit dosage forms of the formulations, and kits comprising such unit dosage forms are also disclosed herein. Methods utilizing the formulations for treating a medical condition treatable by huperzine A are also disclosed herein, as well as processes for preparing the formulations, and uses of huperzine A and albumin in the manufacture of a medicament.
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9.发明公开SUSTAINED RELEASE DELIVERY SYSTEMS FOR THE PREVENTION AND TREATMENT OF HEAD AND NECK CANCERS 有权用于预防RETARD释放系统和头颈部肿瘤的治疗
公开(公告)号：EP2470179A2
公开(公告)日：2012-07-04
申请号：EP10763453.7
申请日：2010-08-25
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. , Hadasit Medical Research Services and Development Ltd. , The U.S.A. as represented by the Secretary, Department of Health and Human Services
发明人： FRIEDMAN, Michael , CZERNINSKI, Rakefet , GUTKIND, Silvio , STEINBERG, Doron , GATI, Irith , NUDELMAN, Zakhar
CPC分类号： A61K31/436 , A61K9/006 , A61K9/2054 , A61K9/7015
摘要： The present invention discloses a method of treating a head and neck cancer or preventing the development of pre-malignant lesions to this cancer, by administering locally to the oral cavity, a sustained release drug delivery system comprising a drug for the treatment of this cancer or for the prevention of said lesions, and at least one polymer, such that said system is attached to a surface in the oral cavity and remains attached thereto for at least 1 hour, accompanied by release of the drug and maintaining an effective therapeutic concentration thereof in the cavity, for at least 1 hour. Further are disclosed a sustained release drug delivery system and a liquid precursor varnish composition to this system.
摘要翻译： 本发明盘松治疗头部和颈部癌症或预防癌前病变的发展这种癌症，通过局部给予至口腔，持续释放的药物递送系统，其包括药物这种癌症的治疗或方法 用于预防说病变，和至少一种聚合物，检查了所述系统被附着到表面在口腔中并保持与其连接为至少1小时，通过将药物的释放伴随以及它们在有效治疗浓度的维护 所述腔，对于至少1小时。 进一步是游离缺失盘的持续释放药物递送系统和液体前体清漆组合物，此系统。
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公开(公告)号：EP2381971A2
公开(公告)日：2011-11-02
申请号：EP10703124.7
申请日：2010-01-12
申请人： Hadasit Medical Research Services & Development Limited , Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
CPC分类号： A61L27/26 , A61L27/3834 , A61L27/502 , A61L31/005 , A61L31/041 , A61L31/141
摘要： The present invention relates to a membrane comprising at least one positively charged, synthetic, hydrophobic polymer, at least one hydrophilic polymer and at least one plasticizer; wherein said membrane is flexible and is capable of supporting at least one of cell adherence, cell proliferation or cell differentiation. The invention further relates to use of a membrane of the invention in the preparation of an implantable devices including cell delivery systems, cell growing surfaces and scaffolds. The invention further provides methods for promoting tissue regeneration in a defected tissue region applying membranes of the invention.
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