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1.发明授权ANTISENSE OLIGONUCLEOTIDE AGAINST HUMAN ACETYLCHOLINESTERASE ISOFORM R (ACHE-R) AND USES THEREOF 有权反义寡核苷酸AGAINST THE R-同种型乙酰胆碱酯酶HUMAN胆碱酯酶（AChE-R）及其用途
公开(公告)号：EP1390493B1
公开(公告)日：2012-11-07
申请号：EP02726406.8
申请日：2002-05-23
发明人： SOREQ, Hermona
IPC分类号： C12N15/113 , C07H21/02 , A61K31/711 , A61P25/00 , A61P21/04
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/53 , C12Y301/01007 , C12N2310/3521
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公开(公告)号：EP3314331A2
公开(公告)日：2018-05-02
申请号：EP16738884.2
申请日：2016-06-29
发明人： BANIN, Uri , SOREQ, Hermona , MAGDASSI, Shlomo , WAISKOPF, Nir , BEN-SHAHAR, Yuval , ASHOK PAWAR, Amol , HALIVNI, Shira
CPC分类号： C09D11/38 , A61K6/0008 , A61K6/0052 , A61K6/0073 , A61K6/083 , B33Y70/00 , B82Y30/00 , C09D11/101 , G03F7/0037 , G03F7/029 , C08L33/26
摘要： Provided is a novel photoinitiator in the form of a hybrid nanoparticle constructed of a semiconductor and metallic regions, and uses thereof.
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3.发明公开READTHROUGH ACETYLCHOLINESTERASE (ACHE-R) FOR TREATING OR PREVENTING PARKINSON'S DISEASE 审中-公开通读乙酰胆碱酯酶（AChE-R），用于治疗或 预防帕金森病
公开(公告)号：EP2613799A1
公开(公告)日：2013-07-17
申请号：EP11767777.3
申请日：2011-09-07
IPC分类号： A61K38/46
CPC分类号： A61K38/465 , A61K47/60 , C12N9/18 , C12Y301/01007
摘要： A method of treating or preventing Parkinson's disease in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of AChE-R, wherein the AChE-R is devoid of an N-terminal extension. An additional method of treating or preventing Parkinson's disease in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of AChE-R, wherein the AChE-R comprises a modification for increasing bioavailability.
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4.发明公开MATERIALS AND METHODS FOR TREATING OR PREVENTING ORGANOPHOSPHATE EXPOSURE ASSOCIATED DAMAGE 审中-公开材料与用于治疗或损害的预防接触有机磷酸酯方法
公开(公告)号：EP2190467A1
公开(公告)日：2010-06-02
申请号：EP07805492.1
申请日：2007-08-20
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. , The Arizona Board of Regents for and on behalf of Arizona State University
发明人： SOREQ, Hermona , MOR, Tsafrir
CPC分类号： A61K9/0019 , A61K9/0073 , A61K9/7007 , A61K38/465 , C12Y301/01007
摘要： A method of treating or preventing organophosphate exposure associated damage in a subject in need thereof is provided. The method comprising providing the subject with a therapeutically effective amount of the acetylcholinesterase splice variant AChE-R ('readthrough' AChE) to thereby. treat the organophosphate exposure associated damage in the subject.
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5.发明公开AGENTS, COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIES IN WHICH REGULATING AN ACHE-ASSOCIATED BIOLOGICAL PATHWAY IS BENEFICIAL 审中-公开IS试剂，组合物和方法用于疾病治疗针对疼痛相关的生物WAY有益的调控
公开(公告)号：EP2134842A2
公开(公告)日：2009-12-23
申请号：EP08719936.0
申请日：2008-03-06
发明人： SOREQ, Hermona , SHAKED, Iftach , AVNI, Ran , MEERSON, Ari
IPC分类号： C12N15/11
CPC分类号： A61K31/7088 , C12N15/1013 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/321 , C12N2310/3231 , C12N2320/50 , C12N2310/3521
摘要： The present invention provides agents which are capable of regulating the function of a micro-RNA component which can be used to regulate an AChE-associated biological pathway. In addition, the present invention provides methods and pharmaceutical compositions for the treatment of various pathologies related to AChE-associated biological pathways such as apoptosis, aberrant cholinergic signaling, abnormal hematopoietic proliferation and/or differentiation, cellular stress, exposure to inflammatory response-inducing agents, and/or exposure to organophosphates or other AChE inhibitors.
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