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    Novel aminoglycosides and use thereof
    2.
    发明公开
    Novel aminoglycosides and use thereof 失效
    新型氨基糖苷类及其用途

    公开(公告)号：EP0071251A1

    公开(公告)日：1983-02-09

    申请号：EP82106794.9

    申请日：1982-07-27

    申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI ,  KOWA COMPANY, LTD.

    发明人： Watanabe, Isamu ,  Yamaguchi, Takashi ,  Kamiya, Kazuhiro ,  Mori, Toshihito ,  Umezawa, Hamao ,  Umezawa, Sumio ,  Tsuchiya, Tsutomu

    IPC分类号： C07H15/22 ,  A61K31/70

    CPC分类号： C07H15/224 ,  C07D303/16 ,  C07H15/226

    摘要： An aminoglycoside compound of the following formula
    wherein one of R, and R 2 represents a hydrogen atom and the other, a methyl group. R 3 represents a hydrogen atom or an ammo acyl group having 2 to 5 carbon atoms. R 4 represents a lower alkyl group substituted by one or two substituents selected from the class consisting of hydroxyl and amino groups, or a hexopyranosyl group whose hydroxy groups may be substituted by amino groups,

    and a pharmaceutically acceptable acid addition salt thereof;
    and an antibiotic composition comprising said compound
    and its pharmaceutically acceptable acid addition salt.

    摘要翻译： 下式的氨基糖苷类化合物，其中R 1和R 2中的一个代表氢原子而另一个代表甲基。 R3代表氢原子或具有2至5个碳原子的氨基酰基。 R4代表被一个或两个选自羟基和氨基的取代基取代的低级烷基或羟基可被氨基取代的己吡喃糖基，及其药学上可接受的酸加成盐; 和包含所述化合物及其药学上可接受的酸加成盐的抗生素组合物。

    3-deoxy mycaminosyl tylonolide derivatives
    5.
    发明公开
    3-deoxy mycaminosyl tylonolide derivatives 失效
    3-脱氧碳霉糖基太乐内酯衍生物

    公开(公告)号：EP0347158A2

    公开(公告)日：1989-12-20

    申请号：EP89305945.1

    申请日：1989-06-13

    申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

    发明人： Umezawa, Sumio ,  Tsuchiya, Tsutomu ,  Takeuchi, Tomio ,  Kageyama, Shunji ,  Sakamoto, Shuichi

    IPC分类号： C07H17/08 ,  A61K31/70

    CPC分类号： C07H17/08

    摘要： 3-Deoxy mycaminosyl tylonolide derivatives represented by the following general formula and salts thereof:
    wherein X represents an oxygen atom or =N-OR⁴ (wherein R⁴ represents hydrogen or lower alkyl); R¹ represents a hydrogen atom, an acyl group or an alkylsilyl group; R² represents a hydrogen atom or an acyl group; and R³ represents a hydrogen atom or a hydroxyl group. The compounds of formula (I) have excellent antibacterial activity.

    摘要翻译： 由下列通式表示的3-脱氧碳霉糖基太乐内酯衍生物及其盐：其中X代表氧原子或= N-OR 4（其中R 4代表氢或低级烷基）; R 1代表氢原子，酰基或烷基甲硅烷基; R 2代表氢原子或酰基; R 3代表氢原子或羟基。 式（I）化合物具有优异的抗菌活性。