PREPARATION METHOD OF 3,7,11-TRIMETHYLDODEC-2,4,6,10-TETRAENE-1-YL PHOSPHONIC SALT
    3.
    发明公开
    PREPARATION METHOD OF 3,7,11-TRIMETHYLDODEC-2,4,6,10-TETRAENE-1-YL PHOSPHONIC SALT 有权
    3,7,11-三甲基二烯-2,4,6,10-四烯-1-基膦酸盐的制备

    公开(公告)号:EP2799440A4

    公开(公告)日:2015-07-01

    申请号:EP12861708

    申请日:2012-12-10

    IPC分类号: C07F9/54

    CPC分类号: C07F9/5442 C07F9/5428

    摘要: Provided in the present invention is a preparation method for a phosphonic salt, comprising the step of: reacting 3,7,11-trimethyldodec-1,4,6,10-tetraene-3-ol with triarylphosphine and an acid in an alcohol solvent at 50-100°C to form the phosphonic salt, wherein the acid is a sulfamic acid or methanesulfonic acid, and the alcohol solvent is a straight chain monohydric alcohol containing 1-5 carbon atoms. The method is performed in nearly neutral conditions, greatly reducing the generation of impurities and greatly obtaining phosphonic salt with an increased E content. The yield of lycopene obtained by using the phosphonic salt as a raw material is high.