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1.发明授权Tissue plasminogen activator analogs having modified growth factor domains 失效具有修饰的组织纤溶酶原激活类似物生长因子结构域。
公开(公告)号：EP0293936B1
公开(公告)日：1995-02-22
申请号：EP88108951.0
申请日：1988-06-03
发明人： Mulvihill, Eileen R. , O'Hara, Patrick J. , Nexo, Bjorn A. , Yoshitake, Shinji , Ikeda, Yasunori , Suzuki, Suguru , Hashimoto, Akira , Yuzuriha, Teruaki
CPC分类号： C12N9/6459 , A61K38/00 , C12Y304/21069
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2.发明公开Tissue plasminogen activator analogs having modified growth factor domains 失效Gewebs-Plasminogen-Aktivator-Analoge mit ModifiziertenWachstumsfaktordomänen。
公开(公告)号：EP0293936A2
公开(公告)日：1988-12-07
申请号：EP88108951.0
申请日：1988-06-03
发明人： Mulvihill, Eileen R. , O'Hara, Patrick J. , Nexo, Bjorn A. , Yoshitake, Shinji , Ikeda, Yasunori , Suzuki, Suguru , Hashimoto, Akira , Yuzuriha, Teruaki
CPC分类号： C12N9/6459 , A61K38/00 , C12Y304/21069
摘要： Tissue plasminogen activator analogs containing the growth factor domain of native t-PA, the domain having at least one cysteine residue replaced with another amino acid. The t-PA analogs may further contain a variety of substitutions and/or modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along with a physiologically acceptable carrier or diluent are also disclosed.
摘要翻译： 含有天然t-PA的生长因子结构域的组织纤溶酶原激活物类似物，具有至少一个半胱氨酸残基的结构域被另一个氨基酸替代。 t-PA类似物还可以包含各种替代和/或修饰。 还公开了含有一种或多种t-PA类似物以及生理上可接受的载体或稀释剂的药物组合物。
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公开(公告)号：EP0293934A1
公开(公告)日：1988-12-07
申请号：EP88108949.4
申请日：1988-06-03
发明人： Mulvihill, Eileen R., , Nexo, Bjorn A., , Yoshitake, Shinji , Ikeda, Yasunori , Suzuki, Suguru , Hashimoto, Akira , Yuzuriha, Teruaki
CPC分类号： C12N9/6459 , A61K38/00 , C12Y304/21069
摘要： Tissue plasminogen activator analogs exhibiting greater specificity for fibrin than native t-PA are disclosed. The analogs include the K1 domain of native t-PA replaced with another kringle domain mediating the binding of the analog to fibrin. The kringle contains six cysteine residues. The t-PA analogs may further include a variety of substitutions and modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along with a physiologically acceptable carrier or diluent are also disclosed.
摘要翻译： 公开了组织纤维蛋白溶酶原激活物类似物对纤维蛋白表现出比天然t-PA更强的特异性。 类似物包括天然t-PA的K1结构域被另一个介导类似物与纤维蛋白结合的三环结构域所取代。 三环含有六个半胱氨酸残基。 t-PA类似物还可以包括各种替代和修饰。 还公开了含有一种或多种t-PA类似物以及生理上可接受的载体或稀释剂的药物组合物。
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公开(公告)号：EP0293934B1
公开(公告)日：1994-08-31
申请号：EP88108949.4
申请日：1988-06-03
发明人： Mulvihill, Eileen R., , Nexo, Bjorn A., , Yoshitake, Shinji , Ikeda, Yasunori , Suzuki, Suguru , Hashimoto, Akira , Yuzuriha, Teruaki
CPC分类号： C12N9/6459 , A61K38/00 , C12Y304/21069
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5.发明公开
公开(公告)号：EP0293936A3
公开(公告)日：1989-09-20
申请号：EP88108951.0
申请日：1988-06-03
发明人： Mulvihill, Eileen R. , O'Hara, Patrick J. , Nexo, Bjorn A. , Yoshitake, Shinji , Ikeda, Yasunori , Suzuki, Suguru , Hashimoto, Akira , Yuzuriha, Teruaki
CPC分类号： C12N9/6459 , A61K38/00 , C12Y304/21069
摘要： Tissue plasminogen activator analogs containing the growth factor domain of native t-PA, the domain having at least one cysteine residue replaced with another amino acid. The t-PA analogs may further contain a variety of substitutions and/or modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along with a physiologically acceptable carrier or diluent are also disclosed.
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公开(公告)号：EP0081831B1
公开(公告)日：1986-03-26
申请号：EP82111494.9
申请日：1982-12-10
申请人： Eisai Co., Ltd.
IPC分类号： C12N9/66
CPC分类号： C12N9/6448 , Y10S435/814
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公开(公告)号：EP0081831A2
公开(公告)日：1983-06-22
申请号：EP82111494.9
申请日：1982-12-10
申请人： Eisai Co., Ltd.
IPC分类号： C12N9/66
CPC分类号： C12N9/6448 , Y10S435/814
摘要： A process is disclosed for purifying elastase by precipitating elastase from an aqueous, elastasecontaining solution, in which the electroconductivity of said aqueous solution is adjusted to 3 millimhos per centimeter or less and the pH of the solution is adjusted to a value of from 2 to 5. The electroconductivity of said aqueous solution is preferably adjusted to 3 millimhos per centimeter or less by means of ultrafiltration.
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公开(公告)号：EP0081831A3
公开(公告)日：1984-08-08
申请号：EP82111494
申请日：1982-12-10
申请人： Eisai Co., Ltd.
IPC分类号： C12N09/66
CPC分类号： C12N9/6448 , Y10S435/814
摘要： A process is disclosed for purifying elastase by precipitating elastase from an aqueous, elastasecontaining solution, in which the electroconductivity of said aqueous solution is adjusted to 3 millimhos per centimeter or less and the pH of the solution is adjusted to a value of from 2 to 5. The electroconductivity of said aqueous solution is preferably adjusted to 3 millimhos per centimeter or less by means of ultrafiltration.
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