公开(公告)号：EP0833930A2

公开(公告)日：1998-04-08

申请号：EP96922445.0

申请日：1996-06-07

申请人： ZymoGenetics, Inc. ,  ANERGEN, INC.

发明人： KINDSVOGEL, Wayne ,  REICH, Eva, Pia ,  GROSS, Jane, A. ,  DESHPANDE, Shrinkant ,  SHEPPARD, Paul, O.

IPC分类号： C12N15 ,  A61K39 ,  A61P37 ,  C07K7 ,  C07K14 ,  C07K19 ,  C12N5 ,  C12N9 ,  C12R1

CPC分类号： C12N9/88 ,  A61K39/00 ,  A61K2039/5158 ,  C07K14/4711 ,  C07K14/70539 ,  C07K2319/00

摘要： Immune modulators, such as soluble, fused MHC heterodimers and soluble, fused MHC heterodimer:peptide complexes, are described. Related methods and peptides are also disclosed. In a preferred aspect, these mediators and methods are related to autoimmunity.

公开(公告)号：EP1436003B3

公开(公告)日：2012-03-14

申请号：EP02734478.7

申请日：2002-05-20

申请人： ZymoGenetics, Inc.

发明人： RIXON, Mark, W. ,  GROSS, Jane, A.

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K14/705

CPC分类号： C07K16/241 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/70578 ,  C07K2319/00 ,  C07K2319/30

摘要： Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptors.

公开(公告)号：EP2283355A2

公开(公告)日：2011-02-16

申请号：EP09735473.2

申请日：2009-04-22

申请人： Zymogenetics, Inc. ,  University of Washington

发明人： GROSS, Jane, A. ,  ELKON, Keith, B. ,  DILLON, Stacey, R.

IPC分类号： G01N33/50

CPC分类号： C07K16/24 ,  C07K14/70578 ,  G01N33/5091 ,  G01N33/564 ,  G01N2333/70575 ,  G01N2800/042 ,  G01N2800/065 ,  G01N2800/101 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/24 ,  G01N2800/285 ,  G01N2800/347

摘要： The present invention provides a method of measuring the levels of BCMA in a biological sample, specifically upon the B cell surface. The diagnostic assays are useful in predicting an individual's likelihood of developing or currently suffering from an autoimmune disease, such as SLE, and for methods for treating an individual clinically diagnosed with an autoimmune disease. This diagnostic test serves to predict a patient's likelihood to respond to a specific drug treatment, in particular treatment with BLyS antagonists, either singly or in combination with other immune suppressive drugs

公开(公告)号：EP1576112A3

公开(公告)日：2005-10-26

申请号：EP03761891.5

申请日：2003-01-21

申请人： ZymoGenetics, Inc.

发明人： SPRECHER, Cindy, A. ,  GAO, Zeren ,  KUIJPER, Joseph, L. ,  DASOVICH, Maria, M. ,  GRANT, Francis, J. ,  PRESNELL, Scott, R. ,  WHITMORE, Theodore, E. ,  HAMMOND, Angela, K. ,  NOVAK, Julia, E. ,  GROSS, Jane, A. ,  DILLON, Stacey, R.

IPC分类号： C12N1/00

公开(公告)号：EP1141274B2

公开(公告)日：2014-11-12

申请号：EP00902354.0

申请日：2000-01-07

申请人： ZymoGenetics, Inc.

发明人： GROSS, Jane, A. ,  XU, Wenfeng ,  MADDEN, Karen ,  YEE, David, P.

IPC分类号： C12N15/11 ,  C07K14/705 ,  A61K38/17 ,  A61K39/395

CPC分类号： C07K14/70575 ,  A61K38/00 ,  C07K14/70578 ,  C07K16/2875 ,  C07K16/2878 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/30

公开(公告)号：EP1407017A2

公开(公告)日：2004-04-14

申请号：EP01990899.5

申请日：2001-11-05

申请人： ZymoGenetics, Inc.

发明人： GROSS, Jane, A. ,  XU, Wenfeng ,  HENNE, Randal, M. ,  GRANT, Francis, J.

IPC分类号： C12N15/12 ,  C07K14/715 ,  C12N15/62 ,  C07K16/28

CPC分类号： C07K14/7151 ,  C07K2319/00 ,  C07K2319/30

摘要： Tumor necrosis factors and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human tumor necrosis factor receptor designated as 'Ztnfr 12'.

公开(公告)号：EP1578907A2

公开(公告)日：2005-09-28

申请号：EP02773788.1

申请日：2002-10-16

申请人： ZymoGenetics, Inc.

发明人： FOX, Brian, A. ,  GROSS, Jane, A.

IPC分类号： C12N1/00

CPC分类号： C07K14/47

摘要： Novel tumor necrosis factor ligand polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides may be used within methods relating to immune response, and may also be used in the development of immuno-regulatory therapeutics. Also provided are antibodies, binding proteins, agonists and antagonists of the ligand polypeptides.

公开(公告)号：EP1436003A2

公开(公告)日：2004-07-14

申请号：EP02734478.7

申请日：2002-05-20

申请人： ZymoGenetics, Inc.

发明人： RIXON, Mark, W. ,  GROSS, Jane, A.

IPC分类号： A61K39/395 ,  C07K16/00

CPC分类号： C07K16/241 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/70578 ,  C07K2319/00 ,  C07K2319/30

摘要： Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptors.

公开(公告)号：EP1165791A2

公开(公告)日：2002-01-02

申请号：EP00916164.7

申请日：2000-03-09

申请人： ZymoGenetics, Inc.

发明人： NOVAK, Julia, E. ,  PRESNELL, Scott, R. ,  SPRECHER, Cindy, A. ,  FOSTER, Donald, C. ,  HOLLY, Richard, D. ,  GROSS, Jane, A. ,  JOHNSTON, Janet, V. ,  NELSON, Andrew, J. ,  DILLON, Stacey, R. ,  HAMMOND, Angela, K.

IPC分类号： C12N15/19 ,  C07K14/52 ,  C12N15/62 ,  C12N15/85 ,  C07K16/24 ,  C12Q1/68 ,  G01N33/68 ,  A61K38/19

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/55

摘要： The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

公开(公告)号：EP1436003B1

公开(公告)日：2009-10-28

申请号：EP02734478.7

申请日：2002-05-20

申请人： ZymoGenetics, Inc.

发明人： RIXON, Mark, W. ,  GROSS, Jane, A.

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K14/705

CPC分类号： C07K16/241 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/70578 ,  C07K2319/00 ,  C07K2319/30