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    IMMUNOGENIC HPV L2-CONTAINING VLPS AND RELATED COMPOSITIONS AND METHODS
    4.
    发明授权
    IMMUNOGENIC HPV L2-CONTAINING VLPS AND RELATED COMPOSITIONS AND METHODS 有权
    免疫原性含HPV L2的VLPS及相关组合物和方法

    公开(公告)号：EP2802349B1

    公开(公告)日：2017-12-06

    申请号：EP13736349.5

    申请日：2013-01-10

    申请人： STC.UNM

    发明人： CHACKERIAN, Bryce ,  PEABODY, David ,  TUMBAN, Ebenezer

    IPC分类号： A61K39/12 ,  C12N7/01 ,  A61P31/20

    CPC分类号： A61K39/12 ,  A61K2039/5258 ,  A61K2039/58 ,  C12N2710/20034 ,  C12N2795/18142 ,  C12N2795/18143

    摘要： In one aspect, the invention provides immunogenic HPV L2-containing viral-like particles (VLPs). Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. In certain aspects, the VLPs are comprised of a coat polypeptide of the bacteriophages PP7 or MS2, wherein the coat protein is modified by insertion of peptide antigens derived from HPV L2, and wherein the HPV L2 peptide is displayed on the VLP and encapsidates PP7 or MS2 mRNA. Specifically, VLPs of the invention display L2 peptides at the N- terminus of the bacteriophage coat protein. Surprisingly, these L2-displaying VLPs induce more broadly neutralizing antibody responses than when the same peptide is displayed in the AB-loop such that the immunogenic response is enhanced by a factor of at least 10. Immunogenic VLPs and related compositions of the invention induce high titer antibody responses against HPV L2 and protect against HPV challenge in vivo.

    Parasite-derived resistance
    8.
    发明公开
    Parasite-derived resistance 失效
    Von Parasit gewonnener Widerstand。

    公开(公告)号：EP0477994A1

    公开(公告)日：1992-04-01

    申请号：EP91117193.2

    申请日：1986-03-17

    申请人： DUKE UNIVERSITY ,  CORNELL RESEARCH FOUNDATION, INC.

    发明人： Johnston, Stephen A. ,  Sanford, John C.

    IPC分类号： C12N15/00 ,  C12N1/21 ,  C12N5/10

    CPC分类号： C12N15/113 ,  A01K2217/05 ,  A01K2267/02 ,  A61K38/00 ,  A61K48/00 ,  C07K14/005 ,  C12N15/8509 ,  C12N15/87 ,  C12N2310/111 ,  C12N2510/00 ,  C12N2795/18122 ,  C12N2795/18143

    摘要： A method for conferring resistance to a parasite to a host of the parasite, which comprises isolating a gene fragment from the parasite and inserting the gene fragment or a DNA or RNA segment substantially homologous to the gene fragment or to a DNA or RNA sequence functionally equivalent to the gene fragment into the host, wherein transcription of the gene fragment or the DNA or RNA segment in the host occurs in an anti-sense direction, or the gene fragment or the DNA or RNA segment is a binding site capable of competing with a native binding site in the parasite, is disclosed along with hosts produced by this process.

    摘要翻译： 一种赋予宿主寄生虫抗性的方法，其包括从寄生虫中分离基因片段，并将基因片段或与基因片段基本上同源的DNA或RNA片段或与功能等同的DNA或RNA序列插入 将基因片段转移到宿主中，其中宿主中的基因片段或DNA或RNA片段的转录以反义方向发生，或者基因片段或DNA或RNA片段是能够与 寄生虫中的天然结合位点与本方法生产的宿主一起披露。

    IMMUNOGENIC HPV L2-CONTAINING VLPS AND RELATED COMPOSITIONS AND METHODS
    10.
    发明公开
    IMMUNOGENIC HPV L2-CONTAINING VLPS AND RELATED COMPOSITIONS AND METHODS 有权
    免疫缺陷型HPV L2-HALTIGE VLPS UND VERWANDTE ZUSAMMENSETZUNGEN UND VERFAHREN

    公开(公告)号：EP2802349A4

    公开(公告)日：2015-08-26

    申请号：EP13736349

    申请日：2013-01-10

    申请人： STC UNM

    发明人： CHACKERIAN BRYCE ,  PEABODY DAVID ,  TUMBAN EBENEZER

    IPC分类号： A61K39/12 ,  A61P31/20 ,  C12N7/01

    CPC分类号： A61K39/12 ,  A61K2039/5258 ,  A61K2039/58 ,  C12N2710/20034 ,  C12N2795/18142 ,  C12N2795/18143

    摘要： In one aspect, the invention provides immunogenic HPV L2-containing viral-like particles (VLPs). Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. In certain aspects, the VLPs are comprised of a coat polypeptide of the bacteriophages PP7 or MS2, wherein the coat protein is modified by insertion of peptide antigens derived from HPV L2, and wherein the HPV L2 peptide is displayed on the VLP and encapsidates PP7 or MS2 mRNA. Specifically, VLPs of the invention display L2 peptides at the N- terminus of the bacteriophage coat protein. Surprisingly, these L2-displaying VLPs induce more broadly neutralizing antibody responses than when the same peptide is displayed in the AB-loop such that the immunogenic response is enhanced by a factor of at least 10. Immunogenic VLPs and related compositions of the invention induce high titer antibody responses against HPV L2 and protect against HPV challenge in vivo.

    摘要翻译： 一方面，本发明提供了含免疫原性的含有HPV L2的病毒样颗粒（VLP）。 还提供了相关组合物（例如疫苗），核酸构建体和治疗方法。 在某些方面，VLP由噬菌体PP7或MS2的外壳多肽组成，其中通过插入衍生自HPV L2的肽抗原修饰外壳蛋白，并且其中HPV L2肽显示在VLP上并且包裹PP7或 MS2 mRNA。 具体地，本发明的VLP在噬菌体外壳蛋白的N-末端显示L2肽。 令人惊讶的是，这些L2显示的VLP诱导比在AB环中显示相同的肽更广泛的中和抗体应答，使得免疫原性应答增加至少10倍。本发明的免疫原性VLP和相关组合物诱导高 针对HPV L2的滴度抗体应答和在体内防止HPV挑战。