公开(公告)号：EP1711831A1

公开(公告)日：2006-10-18

申请号：EP05701314.6

申请日：2005-02-02

申请人： B.R.A.H.M.S. Aktiengesellschaft

发明人： BERGMANN, Andreas ,  STRUCK, Joachim ,  ÜHLEIN, Monika ,  MORGENTHALER, Nils, G.

IPC分类号： G01N33/68 ,  G01N33/569 ,  C12Q1/28

CPC分类号： C12Q1/28 ,  G01N33/56911 ,  G01N33/6893 ,  G01N2800/26

摘要： The invention relates to a method for the early determination of the risk of mortality of patients in intensive care units or emergency care units during which the concentration of Cu/Zn superoxide dismutase (Cu/Zn SOD or SOD-1) in a serum sample or plasma sample of a patient of this type is selectively determined, and quantitatively or semiquantitatively measured concentrations, which exceed a predetermined threshold value, e.g. greater than approximately 310 ng/ml, are correlated with a high risk of mortality.

公开(公告)号：EP1488209B1

公开(公告)日：2005-12-07

申请号：EP04700013.8

申请日：2004-01-29

申请人： B.R.A.H.M.S Aktiengesellschaft

发明人： BERGMANN, Andreas ,  STRUCK, Joachim

IPC分类号： G01N1/00 ,  G01N33/74 ,  G01N33/68

CPC分类号： G01N33/54306 ,  G01N33/574 ,  G01N33/6893 ,  G01N33/74 ,  G01N2800/26

摘要： The invention relates to a method for identifying adrenomedullin immunoreactivity in biological liquids for diagnostic purposes and, to be precise, particularly within the scope of sepsis diagnosis, cardiac diagnosis and cancer diagnosis. According to the invention, the midregional partial peptide (mid-proAM; SEQ ID NO:3) of the proadrenomedullin, which contains amino acids (45-92) of the entire preproadrenomedullin (pre-proAM; SEQ ID NO:1), is measured, in particular, with an immunoassay which works with at least one labeled antibody that specifically recognizes a sequence of the mid-proAM.

公开(公告)号：EP1381628A2

公开(公告)日：2004-01-21

申请号：EP02747282.8

申请日：2002-04-16

申请人： B.R.A.H.M.S Aktiengesellschaft

发明人： BERGMANN, Andreas ,  STRUCK, Joachim ,  ÜHLEIN, Monika

IPC分类号： C07K14/47 ,  G01N33/68

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The invention relates to novel peptides and partial peptide sequences for the diagnosis and treatment of inflammation and sepsis, said peptides and partial peptide sequences being formed during the inflammation and/or infection of primates and humans, and the use of the same or the use of antibodies formed against said peptides for diagnosis and treatment.

公开(公告)号：EP0968427B1

公开(公告)日：2003-06-04

申请号：EP98922615.4

申请日：1998-03-11

申请人： B.R.A.H.M.S Aktiengesellschaft

发明人： STRUCK, Joachim

IPC分类号： G01N33/564

CPC分类号： G01N33/78 ,  G01N33/564 ,  G01N2800/24 ,  Y10S435/973

摘要： The invention relates to a method for detecting thyroid autoantibodies in a biological sample taken from a patient in the context of differential diagnosis of diseases associated with changes in and/or malfunctions of the thyroid. The process of detecting the presence and/or quantity of thyroid autoantibodies in the sample uses an immunodiagnostic method of detection whereby a measurement signal is provided per detection. Said measurement signal generally represents the presence and quantity of at least two antibodies, including anti-TPO-autoantibodies and anti-Tg-autoantibodies, in the sample. Said method increases the selectivity and sensitivity of the detection of autoantibodies typical for certain autoimmune diseases whilst simplifying the process.

公开(公告)号：EP2185938A1

公开(公告)日：2010-05-19

申请号：EP08785311.5

申请日：2008-08-01

申请人： B.R.A.H.M.S Aktiengesellschaft

发明人： BERGMANN, Andreas ,  STRUCK, Joachim ,  MORGENTHALER, Nils, G. ,  PAPASSOTIRIOU, Jana ,  BLANKENBERG, Stefan ,  LACKNER, Karl ,  RUPPRECHT, Hans ,  BICKEL, Christoph

IPC分类号： G01N33/74

CPC分类号： G01N33/74 ,  G01N33/53 ,  G01N2333/585 ,  G01N2800/323 ,  G01N2800/324 ,  G01N2800/50 ,  G01N2800/54

摘要： In vitro method for the risk stratification of patients with stable arteriosclerosis, especially stable coronary artery disease, wherein the concentration of procalcitonin is determined in the circulation of such patients using a highly sensitive PCT assay, and wherein within the range of PCT concentrations in the typical normal range of healthy individuals cutoff values are defined which distinguish groups of individual patients with stable arteriosclerosis in accordance with the personal cardiac risk, and the patients are allotted to one of said risk groups on the basis of their individual PCT concentrations

公开(公告)号：EP1711831B1

公开(公告)日：2008-04-30

申请号：EP05701314.6

申请日：2005-02-02

申请人： B.R.A.H.M.S Aktiengesellschaft

发明人： BERGMANN, Andreas ,  STRUCK, Joachim ,  ÜHLEIN, Monika ,  MORGENTHALER, Nils, G.

IPC分类号： G01N33/68 ,  G01N33/569 ,  C12Q1/28

CPC分类号： C12Q1/28 ,  G01N33/56911 ,  G01N33/6893 ,  G01N2800/26

公开(公告)号：EP1121600B1

公开(公告)日：2006-03-15

申请号：EP99953805.1

申请日：1999-10-13

申请人： B.R.A.H.M.S Aktiengesellschaft

发明人： BERGMANN, Andreas ,  STRUCK, Joachim ,  WEGLÖHNER, Wolfgang

IPC分类号： G01N33/74 ,  C07K14/585 ,  A61K38/23 ,  A61K38/22

CPC分类号： G01N33/74 ,  C07K14/585 ,  G01N2333/585

摘要： The invention relates to applications of recombinant procalcitonin 3-116 for the diagnosis and therapy of septic diseases and to the measurement of prohormones different from procalcitonin and dipeptidyl peptiodase IV as biomarker in the diagnosis of sepsis.

公开(公告)号：EP0943098B1

公开(公告)日：2005-03-09

申请号：EP97952034.3

申请日：1997-12-03

申请人： B.R.A.H.M.S Aktiengesellschaft

发明人： BERGMANN, Andreas ,  STRUCK, Joachim

IPC分类号： G01N33/76 ,  G01N33/68 ,  G01N33/566

CPC分类号： G01N33/76 ,  G01N33/686 ,  Y10S435/963 ,  Y10S435/965 ,  Y10S435/975 ,  Y10S436/811 ,  Y10S530/854

摘要： In a competitive receptor binding assay for detecting TSH-receptor auto-antibodies in a biological sample, the sample is reacted in a reaction mixture which contains (i) a TSH-receptor or TSH-receptor preparation; (ii) a primary competitor, for example labelled TSH; and (iii) an agent for separating a complex composed of the TSH-receptor and the elements bound thereto of the reaction mixture from the liquid phase. According to the invention, the reaction is carried out in the presence of at least one monoclonal or polyclonal antibody specific against a partial peptide sequence of the TSH-receptor. This specific antibody is used to immobilise a complex of TSH-receptor and primary competitor and/or as secondary competitor for another part of the TSH-receptor auto-antibodies expected in a sample. The primary or secondary competitors are or can be selectively labelled.

公开(公告)号：EP1121600B2

公开(公告)日：2014-06-25

申请号：EP99953805.1

申请日：1999-10-13

申请人： B.R.A.H.M.S Aktiengesellschaft

发明人： BERGMANN, Andreas ,  STRUCK, Joachim ,  WEGLÖHNER, Wolfgang

IPC分类号： G01N33/74 ,  C07K14/585 ,  A61K38/23 ,  A61K38/22

CPC分类号： G01N33/74 ,  C07K14/585 ,  G01N2333/585

公开(公告)号：EP2032992A1

公开(公告)日：2009-03-11

申请号：EP08715933.1

申请日：2008-02-21

申请人： B.R.A.H.M.S. Aktiengesellschaft

发明人： BERGMANN, Andreas ,  STRUCK, Joachim

IPC分类号： G01N33/74 ,  C07K16/26 ,  C07K14/585

CPC分类号： G01N33/6854 ,  C07K16/26 ,  C07K2317/34 ,  G01N33/74 ,  G01N2333/585

摘要： Immunoassay for procalcitonin in a biological sample from a patient comprises selectively determining full-length procalcitonin 1-116 with alanine and proline at positions 1 and 2. An independent claim is also included for an antibody that selectively binds to procalcitonin 1-116.

摘要翻译： 免疫测定法，用于从患者的生物样品中的降钙素原包括选择性确定性采矿全长降钙素原1-116与丙氨酸和脯氨酸在位置1和2，一种独立claimsoft因此包含在抗体做选择性结合降钙素原1-116。